short bowel syndrome
Information
- Disease name
- short bowel syndrome
- Disease ID
- DOID:10605
- Description
- "An intestinal disease that is characterized by a reduced ability to absorb nutrients due to the physical loss or the loss of function of a portion of the small and/or large intestine." [url:https\://rarediseases.org/rare-diseases/short-bowel-syndrome/]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05441345 | Active, not recruiting | Sarcopenia and Short Bowel Syndrome | August 18, 2022 | August 17, 2024 | |
| NCT03773237 | Active, not recruiting | N/A | Intralipid Versus SMOFlipid in HPN Patients | December 31, 2018 | September 2024 |
| NCT05018286 | Active, not recruiting | Phase 3 | Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome. | July 13, 2021 | October 30, 2027 |
| NCT01990040 | Active, not recruiting | Registry for Participants With Short Bowel Syndrome | June 23, 2014 | April 30, 2033 | |
| NCT01297933 | Approved for marketing | Compassionate Use of Omegaven for Pediatric Patients With Parenteral Nutrition Associated Liver Disease | |||
| NCT00180648 | Completed | Plasma Determination of Glucagon-like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure | February 2005 | February 2008 | |
| NCT00248573 | Completed | Mechanisms of Adaptation in Human Short Bowel Syndrome | October 2004 | July 2013 | |
| NCT00067860 | Completed | Phase 2 | Diet/Growth Factor Mechanisms of Gut Adaptation | October 1996 | December 2006 |
| NCT06391762 | Completed | Level of Deprivation Assessment in a Population of Short-bowel Syndrome Patients With Intestinal Failure | December 28, 2023 | January 3, 2024 | |
| NCT00767364 | Completed | Phase 1 | Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome | July 2009 | November 2013 |
| NCT00798967 | Completed | Phase 3 | Study of Teduglutide Effectiveness in Parenteral Nutrition (PN)-Dependent Short Bowel Syndrome (SBS) Subjects | November 25, 2008 | January 25, 2011 |
| NCT06102668 | Completed | Survival and PN Dependence in SBS Patients | January 1, 2012 | January 1, 2019 | |
| NCT00910104 | Completed | Phase 2/Phase 3 | Cholestasis Reversal: Efficacy of IV Fish Oil | September 2004 | January 23, 2019 |
| NCT05706012 | Completed | Antithrombotic Management of Acute Mesenteric Ischaemia | June 30, 2023 | February 29, 2024 | |
| NCT00930644 | Completed | Phase 3 | Open-Label Study of Teduglutide for Subjects With PN-Dependent Short Bowel Syndrome (SBS) | September 21, 2009 | January 24, 2013 |
| NCT05181085 | Completed | Phase 1 | Study of NST-6179 in Healthy Subjects | December 7, 2021 | May 30, 2022 |
| NCT01306838 | Completed | Early Phase 1 | Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy | October 2009 | October 2014 |
| NCT01380366 | Completed | Phase 4 | rHGH and Intestinal Permeability in Intestinal Failure | October 2006 | February 2015 |
| NCT05027308 | Completed | Phase 3 | A Study of Teduglutide in Japanese Children With Short Bowel Syndrome Aged 4 Months or Older | January 4, 2022 | September 27, 2023 |
| NCT01560403 | Completed | Phase 3 | A One-Year, Open-Label Study With Teduglutide for Subjects Who Completed Study CL0600-021 | May 21, 2012 | July 23, 2013 |
| NCT01576003 | Completed | N/A | Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants | April 2012 | June 2015 |
| NCT01696656 | Completed | Prescription Pattern of Adjuvant Drugs and Vitamins in Patients Undergoing Long-term Home Nutritional Support for Intestinal Insufficiency | September 2012 | September 2012 | |
| NCT04991311 | Completed | Phase 3 | The Long-term Effect on Intestinal Absorption and Safety of Treatment With Glepaglutide in Patients With Short Bowel Syndrome | August 10, 2021 | September 5, 2023 |
| NCT00081458 | Completed | Phase 3 | Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome | May 25, 2004 | July 6, 2007 |
| NCT04981262 | Completed | N/A | Improved Quality of Life in Children With Intestinal Failure | September 2, 2021 | December 15, 2023 |
| NCT01891279 | Completed | N/A | Elemental Formula in Neonates Post Small Bowel Resection: Improved Weaning From Total Parenteral Nutrition? | September 26, 2011 | September 17, 2013 |
| NCT01900288 | Completed | N/A | Home Parenteral Nutrition (HPN) Families' Mobile Distance Connections to Care Research | August 2012 | December 23, 2016 |
| NCT01930539 | Completed | N/A | Treatment of Vitamin D Deficiency in Intestinal Rehabilitation Clinic Patients With a Portable Ultraviolet B Lamp | September 16, 2013 | December 1, 2015 |
| NCT01946503 | Completed | Infant & Toddler Short Gut Feeding Outcomes Study | April 2013 | May 31, 2023 | |
| NCT01952080 | Completed | Phase 3 | A Pharmacokinetic, Safety, and Pharmacodynamic Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome | November 14, 2013 | January 9, 2015 |
| NCT01974336 | Completed | Phase 4 | The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short Bowel Syndrome Patients | January 2013 | September 2016 |
| NCT00169637 | Completed | Phase 3 | Evaluation of the Efficacy and Safety of Recombinant Human Growth Hormone (rhGH) in the Treatment of Children With Short Bowel Syndrome | June 2006 | June 2008 |
| NCT04450472 | Completed | Nonthyroidal Illness Syndrome in SBS | December 31, 2016 | December 31, 2018 | |
| NCT04119765 | Completed | Plasma Oxalate in Patient With Short Bowel | February 27, 2020 | May 4, 2022 | |
| NCT04141826 | Completed | N/A | Absorption of Peptides, Fluid, and Electrolytes in Patients With an Ileostomy | January 27, 2020 | July 13, 2023 |
| NCT00172185 | Completed | Phase 3 | Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome Who Completed Protocol CL0600-004 (NCT00081458) | January 10, 2005 | January 24, 2008 |
| NCT03663582 | Completed | Phase 3 | Study of Teduglutide in Japanese Participants With Short Bowel Syndrome | July 6, 2018 | August 6, 2019 |
| NCT03690206 | Completed | Phase 3 | Efficacy And Safety Evaluation of Glepaglutide in Treatment of Short Bowel Syndrome (SBS) | October 4, 2018 | July 26, 2022 |
| NCT03980327 | Completed | N/A | Probiotics in Short Bowel Syndrome | January 4, 2017 | December 31, 2018 |
| NCT02099084 | Completed | Phase 4 | Short Bowel Syndrome and Teduglutide Versus Placebo | January 2014 | March 2015 |
| NCT02113228 | Completed | Energy Metabolism in Patients With Short Bowel Syndrome | March 2013 | December 2014 | |
| NCT02142582 | Completed | N/A | Comparison of Different Oral Rehydration Solutions | May 2014 | April 2016 |
| NCT04964986 | Completed | Phase 2 | Metabolic Balance Study of Apraglutide in Patients With SBS-IF and Colon-in-Continuity | June 14, 2021 | June 6, 2023 |
| NCT04916665 | Completed | Bridging Intestinal Failure With Teduglutide - a Case Report | January 1, 2019 | December 31, 2019 | |
| NCT04883606 | Completed | A Study With Teduglutide (Revestive®) in Adults With Short Bowl Syndrome | January 26, 2022 | July 24, 2023 | |
| NCT02340819 | Completed | Phase 3 | Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Teduglutide in Japanese Subjects With PN-dependent Short Bowel Syndrome (SBS) | December 18, 2014 | November 5, 2018 |
| NCT02355743 | Completed | Phase 4 | rtPA in in the Prevention of CVAD-Associated Thrombosis and Infection in Pediatric Patients With Short Bowel Syndrome | February 1, 2015 | September 3, 2016 |
| NCT02370251 | Completed | Phase 2/Phase 3 | Compassionate Use of Omegaven in Children | June 2015 | September 27, 2019 |
| NCT02561819 | Completed | Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients | November 2015 | December 2020 | |
| NCT02682381 | Completed | Phase 3 | Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition | June 23, 2016 | August 18, 2017 |
| NCT02686606 | Completed | N/A | A Trial to Investigate the Effect of Different Supplements on Fluid and Sodium Status in Short Bowel | January 2016 | March 2022 |
| NCT02690025 | Completed | Phase 2 | A Phase 2 Trial Testing ZP1848 in Patients With SBS | February 2016 | May 2017 |
| NCT02699320 | Completed | Intestinal Microbial Dysbiosis in Chinese Infants With Short Bowel Syndrome With Different Complications | June 2015 | January 2016 | |
| NCT04877431 | Completed | A Study of Teduglutide (Revestive®) in Children, Teenagers and Adults With Short Bowel Disease | November 5, 2020 | June 5, 2023 | |
| NCT02949362 | Completed | Phase 3 | Long-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Who Completed the TED-C13-003 Study | December 9, 2016 | July 14, 2020 |
| NCT02953223 | Completed | A Study to Monitor the Use of an Amino Acid-Based Infant Formula | January 2017 | January 2019 | |
| NCT02954458 | Completed | Phase 3 | Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS) | January 9, 2017 | November 5, 2020 |
| NCT02980666 | Completed | Phase 3 | Study in Japanese Pediatric Subjects With Short Bowel Syndrome (SBS) Who Are Dependent on Parenteral Support | January 13, 2017 | January 21, 2020 |
| NCT02987569 | Completed | N/A | Teen and Young Adult Connections for Support From Multidisciplinary Professionals & Peers | July 2016 | June 2020 |
| NCT04867538 | Completed | The Cholelithiasis in Adults With Short Bowel Syndrome | January 1, 2010 | December 31, 2020 | |
| NCT03097029 | Completed | Phase 2 | Use of Pancreatic Enzymes in Short Bowel Syndrome | March 24, 2017 | February 1, 2019 |
| NCT04857801 | Completed | Teduglutide in Short Bowel Syndrome Patients | June 1, 2016 | June 1, 2020 | |
| NCT03268811 | Completed | Phase 3 | A Study in Japanese Children With Short Bowel Syndrome Who Completed SHP633-302 | August 23, 2017 | November 2, 2021 |
| NCT03348709 | Completed | N/A | Osmolality of Oral Supplements and Ileostomy Output | June 1, 2017 | November 1, 2018 |
| NCT03350022 | Completed | N/A | Sham Feeding Post-operative Infants | January 10, 2018 | September 4, 2019 |
| NCT04832087 | Completed | Pediatric Teduglutide Registry | May 18, 2021 | August 31, 2023 | |
| NCT03415594 | Completed | Phase 1/Phase 2 | Safety, Efficacy, PD of FE203799 in Short Bowel Syndrome on Parenteral Support | May 8, 2018 | November 21, 2019 |
| NCT04743960 | Completed | N/A | Assessing Metabolic and Sleep Consequences of Overnight Home Parenteral Nutrition | October 5, 2021 | October 24, 2022 |
| NCT04627025 | Completed | Phase 3 | Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IF | January 26, 2021 | February 22, 2024 |
| NCT00138879 | Completed | Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients | May 2003 | June 2005 | |
| NCT03562130 | Completed | Phase 4 | Characterization of the Long-term Safety, Efficacy, and Pharmacodynamics Revestive® in the Management of Short Bowel Syndrome Pediatric Patients | July 2, 2018 | July 13, 2020 |
| NCT03571516 | Completed | Phase 3 | Safety, Efficacy and Pharmacokinetic Study of Teduglutide in Infants 4 to 12 Months of Age With Short Bowel Syndrome | August 31, 2018 | September 24, 2020 |
| NCT04474743 | Completed | Malnutrition in Chronic Gastrointestinal Diseases, Cross-sectional Study | October 2, 2018 | September 13, 2021 | |
| NCT03596164 | Completed | Phase 3 | An Extension Study of Teduglutide in Japanese Participants With Short Bowel Syndrome Who Completed 24 Weeks of Treatment in SHP633-306 or TED-C14-004 | July 9, 2018 | January 13, 2022 |
| NCT05635747 | Enrolling by invitation | A 90 Day Observational Study as an Extension to the Phase 3,Open Labeled Exploratory Study of RELiZORB | September 29, 2022 | September 29, 2027 | |
| NCT04881825 | Enrolling by invitation | Phase 3 | Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS - Extension Trial | June 16, 2021 | April 2025 |
| NCT06326645 | Not yet recruiting | Early Phase 1 | Open-Label Pilot Study With Crofelemer in Patients With Short Bowel Syndrome | December 1, 2024 | December 1, 2025 |
| NCT06427642 | Recruiting | N/A | Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases | April 1, 2022 | April 30, 2025 |
| NCT01793168 | Recruiting | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford | July 2010 | December 2100 | |
| NCT03530852 | Recruiting | N/A | A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB | November 21, 2018 | September 30, 2028 |
| NCT03905707 | Recruiting | Phase 3 | Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS | May 7, 2019 | December 31, 2024 |
| NCT04344717 | Recruiting | Phase 4 | Pharmacokinetics of Apixaban in Patients With Short Bowel Syndrome Requiring Long Term Parenteral Nutrition | December 20, 2020 | December 2024 |
| NCT04775706 | Recruiting | Phase 2 | Phase 2 Study to Assess the Safety, PK, and PD in SBS-IF Subjects | March 3, 2022 | December 2025 |
| NCT05023382 | Recruiting | A Study of Teduglutide in Japanese People With Short Bowel Syndrome | September 1, 2021 | February 28, 2026 | |
| NCT05302531 | Recruiting | Phase 1 | Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome | December 9, 2022 | February 2025 |
| NCT05535361 | Recruiting | N/A | A Feasibility Study to Evaluate Safety & Benefit of Eclipse XL1 System in Adult Patients With SBS | January 15, 2023 | January 2025 |
| NCT06185088 | Recruiting | N/A | MENDD Tolerance Assessment Study | March 6, 2023 | June 2024 |
| NCT04988997 | Terminated | Phase 2 | VIBRANT Study of Vurolenatide in Adult Patients With Short Bowel Syndrome. | June 14, 2021 | August 24, 2022 |
| NCT03419156 | Terminated | N/A | Effect of a Short Message Service Intervention on Patients With Short Bowel Syndrome | February 20, 2018 | March 21, 2019 |
| NCT03451253 | Terminated | N/A | Effects of an Amino Acid Mixture on Gastrointestinal Function, Inflammation and Fluid Balance: A Pilot Study in Patients With Inflammatory Bowel Disease | April 12, 2018 | March 23, 2021 |
| NCT04046328 | Terminated | Phase 2 | Efficacy, Safety and Tolerability of Enteric-Coated Cholestyramine Capsules for Adult Short Bowel Syndrome | October 15, 2019 | December 22, 2021 |
| NCT03105362 | Terminated | N/A | Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome | August 16, 2017 | April 3, 2018 |
| NCT00742157 | Terminated | Phase 4 | Evaluate the Efficacy and Safety Growth Hormone, Glutamine and Diet in Patients With Short Bowel Syndrome (SBS) | September 1, 2003 | October 20, 2008 |
| NCT02865122 | Terminated | Phase 2/Phase 3 | Safety and Efficacy Study in Infant With SBS | March 20, 2017 | March 22, 2018 |
| NCT02653131 | Terminated | Phase 4 | The Use of DPP-4 Inhibitors in Short Bowel Syndrome | January 2016 | April 2020 |
| NCT02266849 | Terminated | Phase 3 | Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded Cross-over Study | October 2014 | August 2015 |
| NCT01573286 | Terminated | Phase 1/Phase 2 | Safety and Dosing Study of Glucagon-like Peptide 2 (GLP-2) in Infants and Children With Intestinal Failure | January 2012 | August 2015 |
| NCT01739517 | Unknown status | Phase 2 | Efficacy and Safety of Omega-3 Lipid Therapy in Pediatric Patients With Parenteral Nutrition-Associated Liver Disease | March 2009 | December 2013 |
| NCT04976075 | Unknown status | ImpRovE underSTanding of Short bOwel syndRome in Latin-amErica | June 1, 2017 | April 30, 2023 | |
| NCT04733066 | Unknown status | Quality of Life in Patients With Short Bowel Syndrome Treated Without and With Teduglutide - a Prospective Nested Matched Pair Analysis | September 1, 2020 | September 2022 | |
| NCT00673751 | Unknown status | N/A | Effect of the Enteric Hormone Glucagon-Like Peptide (GLP-2) on the Intestinal Blood Flow in Patients With Short Bowel Syndrome | ||
| NCT00793195 | Unknown status | Phase 2 | Can SMOFlipid®, A Composite Parenteral Nutrition Lipid Emulsion, Prevent Progression Of Parenteral Nutrition Associated Liver Disease In Infants? | January 2009 | January 2012 |
| NCT01183793 | Unknown status | N/A | Magnetic Resonance (MR) Enterography Assessment of Post Operative Small Bowel Length in Short Bowel Syndrome Patients | July 2010 | July 2012 |
| NCT04224168 | Unknown status | N/A | Pectin Use in Pediatric Intestinal Rehabilitation | January 1, 2020 | January 2021 |
| NCT04379856 | Unknown status | Phase 1/Phase 2 | Proof of Concept Study in Patients With Short Bowel Syndrome | June 23, 2020 | December 31, 2020 |
| NCT01263574 | Withdrawn | Phase 2 | Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome | February 2011 | September 2012 |
| NCT00876226 | Withdrawn | N/A | Pharmacokinetics of Citalopram in Patients With Short Bowel Syndrome | May 1, 2010 | September 11, 2012 |
| NCT01191177 | Withdrawn | Phase 1/Phase 2 | Investigational Study of Oral Fish Oil in Treating Parenteral Nutrition Associated Liver Disease | January 2011 | January 2012 |
| NCT03054948 | Withdrawn | Phase 4 | SMOFLipid in Patients Who Are Intralipid Intolerant | February 1, 2017 | March 20, 2018 |
| NCT03371862 | Withdrawn | Phase 2 | Liraglutide on Decreasing Parenteral Support in Short Bowel Patients (SLIPS) | October 20, 2017 | September 30, 2020 |
| NCT01818648 | Withdrawn | Phase 4 | Exenatide on GI Motor Function and Permeability in Short Bowel Syndrome | March 2013 | January 2014 |
| NCT02242656 | Withdrawn | Phase 3 | A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Investigational Product MP-101 in Subjects With Short Bowel Syndrome Who Have Had an Inadequate Response to Anti-Diarrheals | December 2014 | |
| NCT03582384 | Withdrawn | Phase 2 | Use of Tocofersolan (Vedrop®) to Prevent or Treat Refractive Vitamin E Deficiency in Infants and Children | December 2020 | January 2023 |
| NCT02246816 | Withdrawn | Phase 3 | A Open Label Extension Study for Subjects That Complete Study MP-101-CL-001 | February 2015 | February 2018 |
| NCT00922805 | Withdrawn | N/A | Fiber Use in Pediatric Short Bowel Syndrome | January 2009 | January 2012 |
| NCT01409772 | Withdrawn | Evaluation of 70% Ethanol Lock Solution to Prevent Catheter Related Blood Stream Infections in Pediatric Patients | May 2009 | July 9, 2009 |
- Disase is a (Disease Ontology)
- DOID:5295
- Cross Reference ID (Disease Ontology)
- MESH:D012778
- Cross Reference ID (Disease Ontology)
- NCI:C99059
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:204768009
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0036992
- Exact Synonym (Disease Ontology)
- acquired short bowel syndrome
- Exact Synonym (Disease Ontology)
- short gut syndrome
- OrphaNumber from OrphaNet (Orphanet)
- 104008
- MeSH unique ID (MeSH (Medical Subject Headings))
- D012778