TRAIL
Information
- Drug Name
- TRAIL
- Description
- Entry(CIViC)
CIViC
[No Data.]
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Surface expression of TRAIL-R1 and -R2 (but not TR... | TNFRSF10C | TNFRSF10C EXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| Surface expression of TRAIL-R1 and -R2 (but not TR... | TNFRSF10D | TNFRSF10D EXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| Reexpressing DR4 by 5-AZAdC in melanoma cells in w... | TNFRSF10A | TNFRSF10A OVEREXPRESSION | Sensitivity | true | MMMP | detail |
| Thapsigargin (an endoplasmic reticulum stress indu... | TNFRSF10B | TNFRSF10B OVEREXPRESSION | Sensitivity | true | MMMP | detail |
| SMAC mimetics are SMAC derived peptides (SMAC phys... | XIAP | XIAP UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| SBHA (HDAC inhibitor) downregulated Bcl-xL, Mcl-1 ... | HDAC9 | HDAC9 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Suppression of ATM-dependent and STAT3-mediated an... | ATM | ATM UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Resveratrol, a polyphenolic phytoalexin, decreased... | STAT3 | STAT3 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Tunicamycin induces ER stress, which in turn leads... | TNFRSF10B | TNFRSF10B OVEREXPRESSION | Sensitivity | true | MMMP | detail |
| UVB cause XIAP degradation, which enhances TRAIL e... | XIAP | XIAP UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Resistance of human melanoma cells against the dea... | CFLAR | CFLAR UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Activation of ERK1/2 protects melanoma cells from ... | MAP2K7 | MAP2K7 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Surface expression of TRAIL-R1 and -R2 (but not TR... | TNFRSF10A | TNFRSF10A EXPRESSION | Sensitivity | true | MMMP | detail |
| Surface expression of TRAIL-R1 and -R2 (but not TR... | TNFRSF10B | TNFRSF10B EXPRESSION | Sensitivity | true | MMMP | detail |
| IFN-beta and TRAIL/Apo2L combination treatment had... | IFNAR1 | IFNAR1 OVEREXPRESSION | Sensitivity | true | MMMP | detail |
| IGF1 acts through upregulation of Bcl-2, Bcl-xL an... | IGF1 | IGF1 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| FLIP may mediate melanoma resistance to apoptosis ... | CFLAR | CFLAR UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Results were based on both expression and siRNA ex... | TNFRSF10A | TNFRSF10A EXPRESSION | Sensitivity | true | MMMP | detail |
| Downregulation of Bcl-2, FLIP or IAPs (XIAP and su... | BCL2 | BCL2 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Downregulation of Bcl-2, FLIP or IAPs (XIAP and su... | CFLAR | CFLAR UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Downregulation of Bcl-2, FLIP or IAPs (XIAP and su... | XIAP | XIAP UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Downregulation of Bcl-2, FLIP or IAPs (XIAP and su... | BIRC5 | BIRC5 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| GALNT14 causes glycosylation of TRAILR | GALNT14 | GALNT14 EXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| Uveal melanoma | BIRC5 | BIRC5 EXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| Uveal melanoma | BIRC5 | BIRC5 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Cisplatin inhibits c-FLIP protein expression and p... | CFLAR | CFLAR UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04908241 | Recruiting | N/A | Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL-RCT) | November 8, 2021 | August 1, 2024 |