Annotation Detail
Information
- Associated Genes
- STAT3
- Associated Variants
- STAT3 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Resveratrol, a polyphenolic phytoalexin, decreased STAT3 and NFkB activation, which suppressed expression of cFLIP and Bcl-xL proteins and increased sensitivity to exogenous TRAIL in DR5-positive melanomas
- MMMP State
- inhibited by
- MMMP Molecule
- STAT3, NFkB
- MMMP Modifier
- Resveratrol
- MMMP Relationship
- sensitivity to
- MMMP Drug
- TRAIL
- MMMP Model
- 3
- MMMP Reference
- Ivanov VN, Exp Cell Res 2008, 314:1163-76
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| TRAIL | Sensitivity | true |