BCL2 UNDEREXPRESSION Detail (hg19) (BCL2)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr18:60,790,579-60,987,361 |
| hg38 | chr18:63,123,346-63,320,128 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
| Type | Database | ID | Link |
|---|---|---|---|
| Gene | MIM | ||
| HGNC | |||
| Ensembl | |||
| NCBI | |||
| Gene Cards | |||
| OncoKB |
| Type | Database | ID | Link |
|---|---|---|---|
| Variant | TogoVar | ||
| COSMIC | |||
| MONDO |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Phase III RCT. Setting: advanced disease. No overall survival advantage; significant increase of pro... | MMMP | Detail |
| Gimatecan is a novel lipophilic camptothecin | MMMP | Detail |
| Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice | MMMP | Detail |
| Lowering the apoptotic threshold enhances immune mediated melanoma cell lysis. ABT-737 does not inhi... | MMMP | Detail |
| Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metast... | MMMP | Detail |
| MG-132: proteasome inhibitor. ABT-737 combined with MG-132 synergistically induced Noxa-dependent mi... | MMMP | Detail |
| Strong synergistic proapoptotic effect of the Bcl-2 family inhibitor ABT-737 and the standard antime... | MMMP | Detail |
| Strong synergistic proapoptotic effect of the Bcl-2 family inhibitor ABT-737 and the standard antime... | MMMP | Detail |
| Strong synergistic proapoptotic effect of the Bcl-2 family inhibitor ABT-737 and the standard antime... | MMMP | Detail |
| Cationic liposomes loaded with proapoptotic peptide D-(KLAKLAK)(2) and Bcl-2 antisense oligodeoxynuc... | MMMP | Detail |
| Mebendazole (an anthelmintic drug) seems to act through Bcl-2 phosphorylation, which prevents Bcl-2 ... | MMMP | Detail |
| Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma ce... | MMMP | Detail |
| If siRNA compounds targeting Bcl-2 were combined with the apoptosis-inducing chemotherapeutic agent ... | MMMP | Detail |
| Anti-Bcl-2 3p-siRNA can both inhibit Bcl-2 expression and activate Rig-I, the immunostimulating cyto... | MMMP | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr18:60,790,579-60,987,361
- Variant Type
- cnv
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