Annotation Detail
Information
- Associated Genes
- BCL2
- Associated Variants
- BCL2 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- If siRNA compounds targeting Bcl-2 were combined with the apoptosis-inducing chemotherapeutic agent cisplatin, a massive increase in apoptotic cell death compared with controls was observed. Notably, the combination of Bcl2 siRNA and low-dose cisplatin resulted in a supra-additive effect, with nearly complete suppression of cell growth, whereas cell growth in cisplatin-only-treated cells was only moderately affected
- MMMP State
- downregulated by
- MMMP Molecule
- Bcl-2
- MMMP Modifier
- Bcl-2 siRNA
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Cisplatin
- MMMP Drug Alias
- CDDP
- MMMP Model
- 3
- MMMP Reference
- Wacheck V, Oligonucleotides 2003, 13:393-400
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cisplatin | Sensitivity | true |