Annotation Detail
Information
- Associated Genes
- BCL2
- Associated Variants
- BCL2 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Strong synergistic proapoptotic effect of the Bcl-2 family inhibitor ABT-737 and the standard antimelanoma drugs, namely, dacarbazine and fotemustine, and the experimental agent, imiquimod. This synergism depends on Noxa, as demonstrated by experiments with Noxa-specific siRNA
- MMMP State
- inhibited by
- MMMP Molecule
- Bcl-2
- MMMP Molecule Alias
- MMMP Modifier
- ABT-738
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Imiquimod
- MMMP Drug Alias
- TLR agonist
- MMMP Model
- 3
- MMMP Reference
- Weber A, Transl Oncol 2009, 2:73-83
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Imiquimod | Sensitivity | true |