Annotation Detail
Information
- Associated Genes
- BCL2
- Associated Variants
- BCL2 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Phase III RCT. Setting: advanced disease. No overall survival advantage; significant increase of progression free survival and tumor response rate
- MMMP State
- downregulated by
- MMMP Molecule
- Bcl-2
- MMMP Modifier
- Oblimersen
- MMMP Modifier Alias
- Bcl-2 antisense oligo, G3139
- MMMP Relationship
- no relationship with
- MMMP Drug
- Dacarbazine
- MMMP Drug Alias
- DTIC
- MMMP Model
- 6
- MMMP Reference
- Bedikian AY, J Clin Oncol 2006, 24:4738-45
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dacarbazine | Resitance or Non-Reponse | true |