Annotation Detail
Information
- Associated Genes
- TNFRSF10B
- Associated Variants
- TNFRSF10B OVEREXPRESSION
- Source Database
- MMMP
- Description
- Thapsigargin (an endoplasmic reticulum stress inducer) sensitizes human melanoma cells to TRAIL-induced apoptosis by upregulation of TRAIL-R2 through the unfolded protein response
- MMMP State
- upregulated by
- MMMP Molecule
- TRAILR2
- MMMP Molecule Alias
- DR5
- MMMP Modifier
- Thapsigargin
- MMMP Relationship
- sensitivity to
- MMMP Drug
- TRAIL
- MMMP Model
- 3
- MMMP Reference
- Chen LH, Carcinogenesis 2007, 28:2328-36
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| TRAIL | Sensitivity | true |