Platinum Compound

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Information
Drug Name
Platinum Compound
Description
Entry(CIViC)
12
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
ovarian carcinoma BRCA1 LOSS-OF-FUNCTION BRCA1 LOSS-OF-FUNCTION B Predictive Supports Sensitivity/Response Rare Germline 3 24240112 Detail
ovarian carcinoma BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION B Predictive Supports Sensitivity/Response Rare Germline 3 24240112 Detail
ovarian carcinoma BRCA1 LOSS-OF-FUNCTION BRCA1 LOSS-OF-FUNCTION B Predictive Supports Sensitivity/Response Somatic 3 24240112 Detail
ovarian carcinoma BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION B Predictive Supports Sensitivity/Response Somatic 3 24240112 Detail
ovarian serous carcinoma AURKA OVEREXPRESSION
( ENST00000395913.7 ) AURKA OVEREXPRESSION
( ENST00000395913.7 ) 		B Predictive Supports Resistance N/A 3 27209210 Detail
bladder carcinoma ERBB2 MUTATION ERBB2 MUTATION C Predictive Supports Sensitivity/Response Somatic 3 25636205 Detail
pancreatic cancer BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION B Predictive Supports Sensitivity/Response Rare Germline 4 25072261 Detail
ovarian cancer ASS1 LOSS ASS1 LOSS D Predictive Supports Resistance Somatic 3 19533750 Detail
head and neck squamous cell carcinoma EGFR AMPLIFICATION
( ENST00000275493.7 ) EGFR AMPLIFICATION
( ENST00000275493.7 ) 		B Predictive Does Not Support Sensitivity/Response Somatic 4 21048039 Detail
lung non-small cell carcinoma WEE1 c.1141+1133A>G
( ENST00000299613.10, ENST00000450114.7, ENST00000681684.1 ) WEE1 c.1141+1133A>G
( ENST00000450114.7, ENST00000681684.1, ENST00000299613.10 ) 		B Predictive Supports Sensitivity/Response Common Germline 3 26057002 Detail
lung non-small cell carcinoma BIRC5 EXPRESSION BIRC5 NUCLEAR EXPRESSION B Predictive Supports Sensitivity/Response N/A 3 24961465 Detail
ovarian cancer BRCA1 UNDEREXPRESSION
( ENST00000357654.9 ) BRCA1 UNDEREXPRESSION
( ENST00000357654.9 ) 		B Predictive Supports Sensitivity/Response Somatic 3 21920589 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
In a study of ovarian carcinomas, 81% of tumors wi... BRCA1 BRCA1 LOSS-OF-FUNCTION BRCA1 LOSS-OF-FUNCTION Sensitivity true CIViC Evidence detail
In a study of ovarian carcinomas, 81% of tumors wi... BRCA2 BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION Sensitivity true CIViC Evidence detail
In a study of ovarian carcinomas, 87% of tumors wi... BRCA1 BRCA1 LOSS-OF-FUNCTION BRCA1 LOSS-OF-FUNCTION Sensitivity true CIViC Evidence detail
In a study of ovarian carcinomas, 87% of tumors wi... BRCA2 BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION Sensitivity true CIViC Evidence detail
A study of 41 patients with high-grade ovarian ser... AURKA AURKA OVEREXPRESSION
( ENST00000395913.7 ) AURKA OVEREXPRESSION
( ENST00000395913.7 ) 		Resitance or Non-Reponse true CIViC Evidence detail
In patients with muscle-invasive bladder chancer, ... ERBB2 ERBB2 MUTATION ERBB2 MUTATION Sensitivity true CIViC Evidence detail
Patients with BRCA1/2 associated pancreatic adenoc... BRCA2 BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION Sensitivity true CIViC Evidence detail
Preclinical evidence for epigenetic inactivation o... ASS1 ASS1 LOSS ASS1 LOSS Resitance or Non-Reponse true CIViC Evidence detail
EGFR amplification was not a predictor of response... EGFR EGFR AMPLIFICATION
( ENST00000275493.7 ) EGFR AMPLIFICATION
( ENST00000275493.7 ) 		Sensitivity false CIViC Evidence detail
The presence of the WEE1 polymorphism rs3910384 co... WEE1 WEE1 c.1141+1133A>G
( ENST00000299613.10, ENST00000450114.7, ENST00000681684.1 ) WEE1 c.1141+1133A>G
( ENST00000450114.7, ENST00000681684.1, ENST00000299613.10 ) 		Sensitivity true CIViC Evidence detail
Patients with nuclear survivin (BIRC5) expression ... BIRC5 BIRC5 EXPRESSION BIRC5 NUCLEAR EXPRESSION Sensitivity true CIViC Evidence detail
Absent/low expression of BRCA1 (IHC) was associate... BRCA1 BRCA1 UNDEREXPRESSION
( ENST00000357654.9 ) BRCA1 UNDEREXPRESSION
( ENST00000357654.9 ) 		Sensitivity true CIViC Evidence detail