Annotation Detail
Information
- Associated Genes
- ASS1
- Associated Variants
-
ASS1 LOSS
ASS1 LOSS - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- Preclinical evidence for epigenetic inactivation of ASS1 as a determinant of response to platinum chemotherapy suggesting that silencing of ASS1 contributes to treatment failure and clinical relapse in ovarian cancer.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/5989
- Gene URL
- https://civic.genome.wustl.edu/links/genes/450
- Variant URL
- https://civic.genome.wustl.edu/links/variants/2230
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Platinum Compound
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 19533750
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Platinum Compound | Resitance or Non-Reponse | true |