Annotation Detail
Information
- Associated Genes
- WEE1
- Associated Variants
-
WEE1 c.1141+1133A>G
(
ENST00000450114.7,
ENST00000681684.1,
ENST00000299613.10 )
WEE1 c.1141+1133A>G ( ENST00000299613.10, ENST00000450114.7, ENST00000681684.1 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- The presence of the WEE1 polymorphism rs3910384 correlated with OS and PFS of NSCLC patients treated with platinum-based chemotherapy. Especially the combination of two DNA-damaging agents was associated with efficacy. 663 patients were tested. The authors showed that rs3910384 is closely linked with the putative functional WEE1 promoter at SNPs rs6486433, rs3763869 and rs3763868.
- Variant Origin
- Common Germline
- Variant Origin
- Common Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/814
- Gene URL
- https://civic.genome.wustl.edu/links/genes/6104
- Variant URL
- https://civic.genome.wustl.edu/links/variants/331
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Gemcitabine,Platinum Compound
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26057002
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Gemcitabine | Sensitivity | true |
| Platinum Compound | Sensitivity | true |