Annotation Detail
Information
- Associated Genes
- BIRC5
- Associated Variants
-
BIRC5 EXPRESSION
BIRC5 NUCLEAR EXPRESSION - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Patients with nuclear survivin (BIRC5) expression had significantly better responses to taxane-platinum chemotherapy than those with low tumor N-survivin expression (P < 0.001) in a retrospective analysis of 48 patients with non-small cell lung cancer.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/874
- Gene URL
- https://civic.genome.wustl.edu/links/genes/355
- Variant URL
- https://civic.genome.wustl.edu/links/variants/368
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Taxane Compound,Platinum Compound
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24961465
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Platinum Compound | Sensitivity | true |
| Taxane Compound | Sensitivity | true |