Annotation Detail
Information
- Associated Genes
- AURKA
- Associated Variants
-
AURKA OVEREXPRESSION
(
ENST00000395913.7 )
AURKA OVEREXPRESSION ( ENST00000395913.7 ) - Associated Disease
- ovarian serous carcinoma
- Source Database
- CIViC Evidence
- Description
- A study of 41 patients with high-grade ovarian serous carcinoma found that high expression levels of AURKA correlated with poorer overall survival (P = 0.001; HR 0.14) and platinum therapy resistance (P < 0.001). Expression of AURKA was measured using immunohistochemical techniques on tumor samples.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1650
- Gene URL
- https://civic.genome.wustl.edu/links/genes/61
- Variant URL
- https://civic.genome.wustl.edu/links/variants/181
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Serous Carcinoma
- Evidence Direction
- Supports
- Drug
- Platinum Compound
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 27209210
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Platinum Compound | Resitance or Non-Reponse | true |