Annotation Detail
Information
- Associated Genes
- BRCA1
- Associated Variants
-
BRCA1 UNDEREXPRESSION
(
ENST00000357654.9 )
BRCA1 UNDEREXPRESSION ( ENST00000357654.9 ) - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- Absent/low expression of BRCA1 (IHC) was associated with improved response to chemotherapy in 292 patients with sporadic ovarian cancer compared to patients with high expression (odds ratio 2.47: 95%CI 1.10-5.55, p=0.029).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/942
- Gene URL
- https://civic.genome.wustl.edu/links/genes/6
- Variant URL
- https://civic.genome.wustl.edu/links/variants/403
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Platinum Compound,Taxane Compound
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21920589
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Platinum Compound | Sensitivity | true |
| Taxane Compound | Sensitivity | true |