chr10:131265454:> Detail (hg19) (MGMT)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr10:131,265,454-131,569,247 |
| hg38 | chr10:129,467,190-129,770,983 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| There was an inverse relationship between MGMT expression and clinical response to DTIC-based chemot... | MMMP | Detail |
| Inhibition of MGMT with O6-benzylguanine resulted in decrease in cell viability and this correlated ... | MMMP | Detail |
| Measurements of pretreatment levels of MGMT in melanoma biopsies did not predict for response to tem... | MMMP | Detail |
| mRNA expression of MGMT, MLH1 and MSH2 in the peripheral blood did not correlate with treatment effi... | MMMP | Detail |
| mRNA expression of MGMT, MLH1 and MSH2 in the peripheral blood did not correlate with treatment effi... | MMMP | Detail |
| In this phase II study of extended-dose TMZ in patients with advanced melanoma, tumor response did n... | MMMP | Detail |
| Uveal melanoma. These results do not support MGMT methylation status or protein expression as predic... | MMMP | Detail |
| MGMT showed a significant correlation with temozolomide sensitivity (MGMT activity, P < 0.0001; MGMT... | MMMP | Detail |
| Increased expression associated with resistance | MMMP | Detail |
| Compared with control cells, both MGMT mRNA and MGMT protein were expressed at a high level in fotem... | MMMP | Detail |
| Acquired resistance to 6-thioguanine in melanoma cells involves the repair enzyme O6-methylguanine-D... | MMMP | Detail |
| Original: underexpression associated with increased toxicity | MMMP | Detail |
| The 93 patients were treated with DTIC or TMZ. Leucopenia and thrombocytopenia were more prevalent a... | MMMP | Detail |
| The 93 patients were treated with DTIC or TMZ. Leucopenia and thrombocytopenia were more prevalent a... | MMMP | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr10:131,265,454-131,569,247
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- EXPRESSION
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/2966
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