Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT EXPRESSION
- Source Database
- MMMP
- Description
- In this phase II study of extended-dose TMZ in patients with advanced melanoma, tumor response did not correlate with MGMT expression or promoter methylation, suggesting that other resistance mechanisms are important
- MMMP State
- expressed
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Relationship
- no relationship with
- MMMP Drug
- Temozolomide
- MMMP Drug Alias
- TMZ
- MMMP Model
- 5
- MMMP Reference
- Rietschel P, J Clin Oncol 2008, 26:2299-304
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Resitance or Non-Reponse | true |