chr10:112998590:C>T Detail (hg38) (TCF7L2, LOC110121472)

Information

Genome

Assembly Position
hg19 chr10:114,758,349-114,758,349 View the variant detail on this assembly version.
hg38 chr10:112,998,590-112,998,590

HGVS

Type Transcript Protein
RefSeq NM_001198528.1:c.382-41435C>T
NM_001146283.1:c.382-41435C>T
NM_001198527.1:c.382-41435C>T
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:[No Data.]
ToMMo:0.045
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:[No Data.]

Prediction

ClinVar

Clinical Significance risk factor
Review star
Show details
Links
Type Database ID Link
Gene MIM 602228 OMIM
HGNC 11641 HGNC
Ensembl ENSG00000148737 Ensembl
NCBI NCBI
Gene Cards Gene Cards
OncoKB OncoKB
Type Database ID Link
Variant TogoVar tgv40707751 TogoVar
COSMIC
MONDO
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
risk factor 2011-09-01 no assertion criteria provided Diabetes mellitus type 2, susceptibility to germline Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.329 Diabetes Mellitus, Non-Insulin-Dependent In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... BeFree 18498634 Detail
0.393 Diabetes Mellitus, Non-Insulin-Dependent In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... BeFree 18498634 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... BeFree 18498634 Detail
0.330 Diabetes Mellitus, Non-Insulin-Dependent In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... BeFree 18498634 Detail
0.340 Diabetes Mellitus, Non-Insulin-Dependent In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... BeFree 18498634 Detail
0.322 Diabetes Mellitus, Non-Insulin-Dependent In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... BeFree 18498634 Detail
<0.001 gestational diabetes Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... BeFree 23761423 Detail
<0.001 gestational diabetes Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... BeFree 23761423 Detail
0.014 gestational diabetes Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... BeFree 23761423 Detail
<0.001 gestational diabetes Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... BeFree 23761423 Detail
<0.001 gestational diabetes Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... BeFree 23761423 Detail
<0.001 gestational diabetes Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... BeFree 23761423 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Given the overlap between PCOS and T2DM, we investigated the association of tran... BeFree 24157263 Detail
0.014 gestational diabetes Association with GDM was found for two of the most frequently replicated T2D loc... BeFree 25973943 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Two hundred and fifty patients identified as LADA, divided into two subgroups wi... BeFree 20546291 Detail
<0.001 Diabetes Mellitus, Insulin-Dependent Two hundred and fifty patients identified as LADA, divided into two subgroups wi... BeFree 20546291 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent TCF7L2 variants rs12255372 and rs7903146 have been associated with risk of Type ... BeFree 23085767 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are asso... BeFree 17697858 Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent Two hundred and fifty patients identified as LADA, divided into two subgroups wi... BeFree 20546291 Detail
0.013 Hyperlipidemia, Familial Combined We investigated the effect of the TCF7L2 variants, rs7903146 and rs12255372, on ... BeFree 17972059 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene ... BeFree 25185411 Detail
0.127 Malignant neoplasm of breast Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association o... BeFree 21301999 Detail
0.004 Diabetes Mellitus, Insulin-Dependent Two hundred and fifty patients identified as LADA, divided into two subgroups wi... BeFree 20546291 Detail
0.004 breast carcinoma Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association o... BeFree 21301999 Detail
<0.001 diabetes mellitus Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when cont... BeFree 18972257 Detail
<0.001 Diabetes Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when cont... BeFree 18972257 Detail
0.014 gestational diabetes Among them, genetic variants in TCF7L2 showed the strongest association with GDM... BeFree 23690305 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene wit... BeFree 25299103 Detail
0.012 hyperglycemia Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... BeFree 18853134 Detail
0.003 hyperglycemia Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... BeFree 18853134 Detail
0.004 pancreatic carcinoma We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 pancreatic carcinoma We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 pancreatic carcinoma We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 Malignant neoplasm of pancreas We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 Malignant neoplasm of pancreas We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 Malignant neoplasm of pancreas We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
0.003 Malignant neoplasm of pancreas We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 pancreatic carcinoma We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 Malignant neoplasm of pancreas We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
<0.001 pancreatic carcinoma We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... BeFree 25516658 Detail
0.030 obesity Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... BeFree 18853134 Detail
<0.001 hyperglycemia Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... BeFree 18853134 Detail
0.336 Diabetes Mellitus, Non-Insulin-Dependent Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... BeFree 23144361 Detail
0.452 Diabetes Mellitus, Non-Insulin-Dependent Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... BeFree 23144361 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... BeFree 23144361 Detail
0.327 Diabetes Mellitus, Non-Insulin-Dependent Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... BeFree 23144361 Detail
0.014 gestational diabetes Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... BeFree 20540670 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... BeFree 20540670 Detail
0.627 Diabetes Mellitus, Non-Insulin-Dependent Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... BeFree 20540670 Detail
0.005 gestational diabetes Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... BeFree 20540670 Detail
0.447 Diabetes Mellitus, Non-Insulin-Dependent In fact, we evaluated the effect of seven polymorphisms in the following genes-P... BeFree 23249316 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent In fact, we evaluated the effect of seven polymorphisms in the following genes-P... BeFree 23249316 Detail
0.316 Diabetes Mellitus, Non-Insulin-Dependent In fact, we evaluated the effect of seven polymorphisms in the following genes-P... BeFree 23249316 Detail
0.094 Diabetes Mellitus, Non-Insulin-Dependent In fact, we evaluated the effect of seven polymorphisms in the following genes-P... BeFree 23249316 Detail
0.129 Metabolic syndrome X Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... BeFree 18853134 Detail
0.001 colorectal carcinoma Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(... BeFree 22419714 Detail
0.001 colorectal cancer Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(... BeFree 22419714 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms in TCF7L... BeFree 23536853 Detail
0.144 Metabolic syndrome X The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... BeFree 21749608 Detail
0.101 Metabolic syndrome X The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... BeFree 21749608 Detail
0.129 Metabolic syndrome X The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... BeFree 21749608 Detail
0.171 Metabolic syndrome X The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... BeFree 21749608 Detail
0.019 Diabetes These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... BeFree 17977958 Detail
0.466 Diabetes Mellitus, Non-Insulin-Dependent A case-control design comprising 884 type 2 diabetic patients and 513 control su... BeFree 19368707 Detail
0.018 Diabetes These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... BeFree 17977958 Detail
0.415 Diabetes Mellitus, Non-Insulin-Dependent A case-control design comprising 884 type 2 diabetic patients and 513 control su... BeFree 19368707 Detail
0.466 Diabetes Mellitus, Non-Insulin-Dependent Given the phenotypic overlap between PCOS and T2DM, our objective was to investi... BeFree 18958766 Detail
0.214 Diabetes Mellitus, Non-Insulin-Dependent A case-control design comprising 884 type 2 diabetic patients and 513 control su... BeFree 19368707 Detail
0.045 diabetes mellitus These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... BeFree 17977958 Detail
0.060 diabetes mellitus These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... BeFree 17977958 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Given the phenotypic overlap between PCOS and T2DM, our objective was to investi... BeFree 18958766 Detail
0.421 Diabetes Mellitus, Non-Insulin-Dependent In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic s... BeFree 22923468 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic s... BeFree 22923468 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent In the obese-type 2 diabetes scan, FTO variants had the strongest type 2 diabete... BeFree 19056611 Detail
<0.001 ovarian carcinoma The present meta-analysis indicated that there were significantly associations b... BeFree 23951231 Detail
0.005 Impaired glucose tolerance In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabet... BeFree 17593304 Detail
0.274 hyperglycemia We confirmed that the risk allele of rs7903146 is associated with hyperglycaemia... BeFree 19183934 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent We mapped sequence variants to open chromatin sites and found that rs7903146, a ... BeFree 20118932 Detail
0.030 obesity The observed trends of obesity risk alleles for risk of stroke/TIA as well as th... BeFree 21921652 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent In the Tunisian population, TCF7L2-rs7903146 T allele confers an increased risk ... BeFree 19368707 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) ... BeFree 19585101 Detail
0.374 Diabetes Mellitus, Non-Insulin-Dependent Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic l... BeFree 24925104 Detail
0.374 Diabetes Mellitus, Non-Insulin-Dependent The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been ... BeFree 19473183 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated... BeFree 24529562 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Together, data from our study show that TCF7L2-rs7903146 is associated with PDR ... BeFree 23434931 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabet... BeFree 17593304 Detail
0.002 prostate carcinoma The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominan... BeFree 20142250 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent There are conflicting reports about the significance of TCF7L2 single nucleotide... BeFree 19573884 Detail
0.003 Ovarian Diseases The findings of this systemic analysis suggest that the polymorphism of TCF7L2 r... BeFree 24815492 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Me... GWASCAT 24390345 Detail
0.466 Diabetes Mellitus, Non-Insulin-Dependent Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... BeFree 17020404 Detail
0.001 Coronary Arteriosclerosis TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 di... BeFree 19055834 Detail
0.274 hyperglycemia We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hype... BeFree 17065361 Detail
0.154 Diabetes Mellitus, Non-Insulin-Dependent Reduced paracrine glucagon stimulation may contribute to the impairment of beta-... BeFree 20107109 Detail
0.045 diabetes mellitus Human genetic studies have revealed that the T minor allele of single nucleotide... BeFree 25058603 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Elevated hepatic glucose production and reduced insulinotropic effect of increti... BeFree 19288077 Detail
0.002 Weight Loss Adverse Event [Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistanc... GAD 18762805 Detail
0.127 hyperglycemia Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... BeFree 22461567 Detail
0.018 Diabetes Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid scr... BeFree 19169495 Detail
0.018 Diabetes Resequencing and analysis of variation in the TCF7L2 gene in African Americans s... BeFree 20980453 Detail
0.045 diabetes mellitus After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... BeFree 22591707 Detail
0.018 Diabetes Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... BeFree 22461567 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Glucose Metabolism in High-Risk Subjects for Type 2 Diabetes Carrying the rs7903... BeFree 26046964 Detail
0.004 Dyslipidemias The results from published studies regarding association of transcription factor... BeFree 26576435 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 aga... BeFree 26576435 Detail
0.008 Diabetes After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... BeFree 22591707 Detail
0.030 obesity Transcripts retaining exons 13 and 13a but not total TCF7L2 transcripts were sig... BeFree 20097709 Detail
0.006 coronary artery disease TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severit... BeFree 19924244 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAM... GWASCAT 22693455 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Association of variant rs7903146 (C/T) single nucleotide polymorphism of TCF7L2 ... BeFree 24214952 Detail
0.030 obesity Relationship of transcription factor 7 like 2 gene rs7903146 variation with type... BeFree 23014255 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent We identify T2D-associated variants in an intergenic region of chromosome 11p12,... GWASCAT 17463248 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent TCF7L2 is the strongest locus linked to type 2 diabetes that has been identified... BeFree 19864407 Detail
0.018 Diabetes We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the ... BeFree 18268068 Detail
0.018 Diabetes Human genetic studies have revealed that the T minor allele of single nucleotide... BeFree 25058603 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Meta-analysis of genome-wide association data and large-scale replication identi... GWASCAT 18372903 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelan... GWASCAT 17460697 Detail
0.045 diabetes mellitus Our study provides the first significant evidence of association between the TCF... BeFree 18931037 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghan... BeFree 24059590 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Genome-wide association study identifies three novel loci for type 2 diabetes. GWASCAT 23945395 Detail
0.045 diabetes mellitus We investigated the association between the TCF7L2 rs7903146 polymorphism and in... BeFree 20578204 Detail
<0.001 Cerebrovascular accident Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated... BeFree 24529562 Detail
0.012 hyperglycemia Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... BeFree 22461567 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Genome-wide trans-ancestry meta-analysis provides insight into the genetic archi... GWASCAT 24509480 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Subsequent GWAS using data from five institutions replicated the TCF7L2 gene var... BeFree 22101970 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Reduced paracrine glucagon stimulation may contribute to the impairment of beta-... BeFree 20107109 Detail
0.006 Obesity, Abdominal Female minor T allele carriers of rs7903146 had increased MetS risk (odds ratio ... BeFree 21543200 Detail
0.045 diabetes mellitus In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs79031... BeFree 19055834 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Twelve type 2 diabetes susceptibility loci identified through large-scale associ... GWASCAT 20581827 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes... BeFree 20032493 Detail
0.001 Diabetes The FHS cohort supported these results: The rs7903146 T allele was significantly... BeFree 18650481 Detail
<0.001 hepatitis C rs7903146 polymorphism at transcription factor 7 like 2 gene is associated with ... BeFree 25353718 Detail
0.001 Coronary Arteriosclerosis TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severit... BeFree 19924244 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with ty... BeFree 20957343 Detail
0.003 Overweight Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance... BeFree 18762805 Detail
0.341 Diabetes Mellitus, Non-Insulin-Dependent The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighte... BeFree 22591707 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs79... BeFree 18310307 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Meta-analysis of genome-wide association studies in African Americans provides i... GWASCAT 25102180 Detail
0.045 diabetes mellitus Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid scr... BeFree 19169495 Detail
0.005 Impaired glucose tolerance [Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly... GAD 18611970 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Relationship of transcription factor 7 like 2 gene rs7903146 variation with type... BeFree 23014255 Detail
<0.001 Malignant neoplasm of ovary The present meta-analysis indicated that there were significantly associations b... BeFree 23951231 Detail
0.004 Cardiovascular Diseases In summary, high (n-6) PUFA intakes (&gt; or = 6.62% of energy intake) were asso... BeFree 19141698 Detail
<0.001 gestational diabetes The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighte... BeFree 22591707 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly... BeFree 25498973 Detail
0.001 diabetes mellitus The FHS cohort supported these results: The rs7903146 T allele was significantly... BeFree 18650481 Detail
0.018 Diabetes In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs79031... BeFree 19055834 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent One TCF7L2 SNP (rs7903146) showed compelling evidence of association with type 2... BeFree 18443202 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabet... BeFree 25627047 Detail
0.129 Metabolic syndrome X In summary, high (n-6) PUFA intakes (&gt; or = 6.62% of energy intake) were asso... BeFree 19141698 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... BeFree 21169132 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Genome-wide association analysis identifies loci for type 2 diabetes and triglyc... GWASCAT 17463246 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Our results point to a protein complex binding across rs7903146 within TCF7L2 an... BeFree 24667787 Detail
<0.001 Diabetes The FHS cohort supported these results: The rs7903146 T allele was significantly... BeFree 18650481 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Confirmation of multiple risk Loci and genetic impacts by a genome-wide associat... GWASCAT 19401414 Detail
0.003 Overweight [Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistanc... GAD 18762805 Detail
0.001 Coronary heart disease We genotyped the single nucleotide polymorphisms (SNP) rs7903146 of the TCF7L2 g... BeFree 19055834 Detail
0.009 Coronary heart disease TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severit... BeFree 19924244 Detail
0.004 Cardiovascular Diseases We described for the first time a strong relationship between the TCF7L2 gene va... BeFree 24574000 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... BeFree 17020404 Detail
0.018 Diabetes The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significant... BeFree 20437825 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Association of the rs7903146 single nucleotide polymorphism at the Transcription... BeFree 23295285 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been ... BeFree 19473183 Detail
0.295 diabetes mellitus Since the association with diabetes could be explained by effects on insulin sec... BeFree 21349175 Detail
0.024 Insulin resistance [Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistanc... GAD 18762805 Detail
0.095 Diabetes Mellitus, Non-Insulin-Dependent As TCF7L2 rs7903146 has been associated with diminished incretin effect we inves... BeFree 22782288 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The T allele of the single-nucleotide polymorphism rs7903146 in TCF7L2 (transcri... BeFree 18762805 Detail
0.004 Malignant tumor of colon The present meta-analysis indicated that there were significantly associations b... BeFree 23951231 Detail
0.393 Diabetes Mellitus, Non-Insulin-Dependent Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... BeFree 21169132 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent [Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits... GAD 21873549 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: g... BeFree 19149908 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Our results suggest synergistic effects of WNT16a insertion and the at-risk 'T' ... BeFree 23617586 Detail
0.045 diabetes mellitus These data provide evidence that the beneficial effect of whole-grain intake on ... BeFree 19149908 Detail
0.045 diabetes mellitus The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significant... BeFree 20437825 Detail
0.004 Dyslipidemias In summary, high (n-6) PUFA intakes (&gt; or = 6.62% of energy intake) were asso... BeFree 19141698 Detail
0.466 Diabetes Mellitus, Non-Insulin-Dependent Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... BeFree 21169132 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Polymorphisms in transcription factor 7-like 2 (TCF7L2) have been associated wit... BeFree 25117344 Detail
<0.001 metabolic disturbance Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associate... BeFree 25353718 Detail
0.014 gestational diabetes Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7... BeFree 23855352 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent [Variation in the transcription factor 7-like 2 (TCF7L2) locus is associated wit... GAD 20980453 Detail
0.003 Ovarian Diseases Our findings provide convincing evidence that TCF7L2 genetic polymorphisms may c... BeFree 24611738 Detail
<0.001 diabetes mellitus The FHS cohort supported these results: The rs7903146 T allele was significantly... BeFree 18650481 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent This identified four loci containing variants that confer type 2 diabetes risk, ... GWASCAT 17293876 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incre... BeFree 19934000 Detail
0.001 Metabolic syndrome X This study investigated the relationship between the TCF7L2 rs7903146 polymorphi... BeFree 21543200 Detail
0.024 Insulin resistance [Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clam... GAD 19573884 Detail
0.030 obesity TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a ... BeFree 20032493 Detail
0.018 Diabetes Our study provides the first significant evidence of association between the TCF... BeFree 18931037 Detail
0.045 diabetes mellitus We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the ... BeFree 18268068 Detail
0.045 diabetes mellitus Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... BeFree 22461567 Detail
0.018 Diabetes We investigated the association between the TCF7L2 rs7903146 polymorphism and in... BeFree 20578204 Detail
0.025 diabetes mellitus After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... BeFree 22591707 Detail
0.024 Insulin resistance [Healthy carriers of the T-allele of TCF7L2 rs7903146 exhibit a diminished incre... GAD 20107109 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent [Subsequent GWAS using data from five institutions replicated the TCF7L2 gene va... GAD 22101970 Detail
0.045 diabetes mellitus Resequencing and analysis of variation in the TCF7L2 gene in African Americans s... BeFree 20980453 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Genome-wide association study identifies a novel locus contributing to type 2 di... GWASCAT 23300278 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in a... BeFree 25491720 Detail
0.006 coronary artery disease [TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severi... GAD 19924244 Detail
0.080 Diabetes Since the association with diabetes could be explained by effects on insulin sec... BeFree 21349175 Detail
0.018 Diabetes These data provide evidence that the beneficial effect of whole-grain intake on ... BeFree 19149908 Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent SNP rs7903146 of the TCF7L2 gene was significantly associated with type 2 diabet... BeFree 19055834 Detail
0.009 Coronary heart disease TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 di... BeFree 19055834 Detail
0.129 Metabolic syndrome X A genome-wide association study of the metabolic syndrome in Indian Asian men. GWASCAT 20694148 Detail
0.001 Diabetic Nephropathy In our study the T allele of the rs7903146 SNP in the TCF7L2 gene confers the ri... BeFree 24574000 Detail
0.004 Cardiovascular Diseases Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associate... BeFree 25353718 Detail
0.018 Diabetes After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... BeFree 22591707 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk f... BeFree 19713311 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Recently, case-control studies demonstrated that a TCF7L2 (transcription factor ... BeFree 17065361 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent [These results suggest that individuals with increased genetic susceptibility to... GAD 20203524 Detail
0.007 Malignant neoplasm of prostate The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominan... BeFree 20142250 Detail
0.393 Diabetes Mellitus, Non-Insulin-Dependent Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... BeFree 17020404 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic l... BeFree 24925104 Detail
0.374 Diabetes Mellitus, Non-Insulin-Dependent There are conflicting reports about the significance of TCF7L2 single nucleotide... BeFree 19573884 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent When a stringent statistical correction for multiple testing was used, the only ... GWASCAT 17668382 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Genome-wide association study for type 2 diabetes in Indians identifies a new su... GWASCAT 23209189 Detail
<0.001 hereditary multiple exostoses The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly... BeFree 25498973 Detail
0.008 proliferative diabetic retinopathy Together, data from our study show that TCF7L2-rs7903146 is associated with PDR ... BeFree 23434931 Detail
0.340 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
0.393 Diabetes Mellitus, Non-Insulin-Dependent Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nom... BeFree 20161779 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
0.466 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
0.055 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
<0.001 prediabetes syndrome This cross-sectional study aimed to investigate the independent risk factors for... BeFree 26334876 Detail
0.042 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
0.029 Diabetes Mellitus, Non-Insulin-Dependent Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nom... BeFree 20161779 Detail
0.121 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
0.009 gestational diabetes 13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HH... BeFree 22591707 Detail
0.090 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
0.025 Diabetes Mellitus, Non-Insulin-Dependent Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... BeFree 25839936 Detail
0.005 gestational diabetes The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... BeFree 23690305 Detail
0.123 gestational diabetes The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... BeFree 23690305 Detail
0.002 gestational diabetes The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... BeFree 23690305 Detail
0.009 gestational diabetes The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... BeFree 23690305 Detail
0.126 gestational diabetes The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... BeFree 23690305 Detail
0.145 gestational diabetes The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... BeFree 23690305 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent We genotyped the TCF7L2 single nucleotide polymorphisms rs7903146 and rs12255372... BeFree 19183934 Detail
0.214 Diabetes Mellitus, Non-Insulin-Dependent In addition to these polymorphisms, meta-analysis confirmed the association of t... BeFree 19033397 Detail
0.006 obesity In this study, we asked whether the co-occurrence of risk alleles in or near fiv... BeFree 24062323 Detail
0.003 Impaired glucose tolerance In this study, we asked whether the co-occurrence of risk alleles in or near fiv... BeFree 24062323 Detail
0.214 Diabetes Mellitus, Non-Insulin-Dependent In this study, we asked whether the co-occurrence of risk alleles in or near fiv... BeFree 24062323 Detail
0.011 obesity In this study, we asked whether the co-occurrence of risk alleles in or near fiv... BeFree 24062323 Detail
0.466 Diabetes Mellitus, Non-Insulin-Dependent In addition to these polymorphisms, meta-analysis confirmed the association of t... BeFree 19033397 Detail
0.329 Diabetes Mellitus, Non-Insulin-Dependent In this study, we asked whether the co-occurrence of risk alleles in or near fiv... BeFree 24062323 Detail
0.162 polycystic ovary syndrome This study was to evaluate whether polymorphisms of TCF7L2 (rs7903146) and HHEX ... BeFree 20041287 Detail
0.007 Impaired glucose tolerance In this study, we asked whether the co-occurrence of risk alleles in or near fiv... BeFree 24062323 Detail
0.006 coronary artery disease These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 ... BeFree 21423583 Detail
0.045 diabetes mellitus We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, r... BeFree 18291022 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 ... BeFree 21423583 Detail
0.018 Diabetes We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, r... BeFree 18291022 Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent We compared genotype frequencies in subjects with type 2 diabetes with those wit... BeFree 16936218 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent NA CLINVAR Detail
0.340 Diabetes Mellitus, Non-Insulin-Dependent A case-control study was performed in Han Chinese subjects with normal control (... BeFree 21437630 Detail
0.136 colorectal cancer A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... BeFree 22419714 Detail
<0.001 colorectal carcinoma A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... BeFree 22419714 Detail
0.011 colorectal carcinoma A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... BeFree 22419714 Detail
<0.001 colorectal cancer A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... BeFree 22419714 Detail
Annotation

Annotations

DescrptionSourceLinks
NM_001367943.1(TCF7L2):c.450+33966C>T AND Diabetes mellitus type 2, susceptibility to ClinVar Detail
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... DisGeNET Detail
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... DisGeNET Detail
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... DisGeNET Detail
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... DisGeNET Detail
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... DisGeNET Detail
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... DisGeNET Detail
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... DisGeNET Detail
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... DisGeNET Detail
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... DisGeNET Detail
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... DisGeNET Detail
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... DisGeNET Detail
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... DisGeNET Detail
Given the overlap between PCOS and T2DM, we investigated the association of transcription factor-7-l... DisGeNET Detail
Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotyp... DisGeNET Detail
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (&lt; or = 32... DisGeNET Detail
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (&lt; or = 32... DisGeNET Detail
TCF7L2 variants rs12255372 and rs7903146 have been associated with risk of Type 2 diabetes. DisGeNET Detail
The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 d... DisGeNET Detail
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (&lt; or = 32... DisGeNET Detail
We investigated the effect of the TCF7L2 variants, rs7903146 and rs12255372, on FCHL and its compone... DisGeNET Detail
Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes... DisGeNET Detail
Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(... DisGeNET Detail
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (&lt; or = 32... DisGeNET Detail
Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(... DisGeNET Detail
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for tradition... DisGeNET Detail
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for tradition... DisGeNET Detail
Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95%... DisGeNET Detail
Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in... DisGeNET Detail
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... DisGeNET Detail
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... DisGeNET Detail
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... DisGeNET Detail
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... DisGeNET Detail
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... DisGeNET Detail
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... DisGeNET Detail
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... DisGeNET Detail
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... DisGeNET Detail
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... DisGeNET Detail
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... DisGeNET Detail
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... DisGeNET Detail
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... DisGeNET Detail
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... DisGeNET Detail
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... DisGeNET Detail
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... DisGeNET Detail
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... DisGeNET Detail
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... DisGeNET Detail
Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(trend) = 0.02), wher... DisGeNET Detail
Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(trend) = 0.02), wher... DisGeNET Detail
Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms in TCF7L2 with type 2 diabet... DisGeNET Detail
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... DisGeNET Detail
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... DisGeNET Detail
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... DisGeNET Detail
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... DisGeNET Detail
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... DisGeNET Detail
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the... DisGeNET Detail
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... DisGeNET Detail
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the... DisGeNET Detail
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF... DisGeNET Detail
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the... DisGeNET Detail
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... DisGeNET Detail
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... DisGeNET Detail
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF... DisGeNET Detail
In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7... DisGeNET Detail
In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7... DisGeNET Detail
In the obese-type 2 diabetes scan, FTO variants had the strongest type 2 diabetes effect (rs8050136:... DisGeNET Detail
The present meta-analysis indicated that there were significantly associations between the TCF7L2 rs... DisGeNET Detail
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been a... DisGeNET Detail
We confirmed that the risk allele of rs7903146 is associated with hyperglycaemia and a higher proins... DisGeNET Detail
We mapped sequence variants to open chromatin sites and found that rs7903146, a TCF7L2 intronic vari... DisGeNET Detail
The observed trends of obesity risk alleles for risk of stroke/TIA as well as the possible sex-speci... DisGeNET Detail
In the Tunisian population, TCF7L2-rs7903146 T allele confers an increased risk of developing T2D as... DisGeNET Detail
A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) was associated with ... DisGeNET Detail
Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic level in humans, but ... DisGeNET Detail
The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been associated with risk... DisGeNET Detail
Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type... DisGeNET Detail
Together, data from our study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM an... DisGeNET Detail
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been a... DisGeNET Detail
The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR,... DisGeNET Detail
There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903... DisGeNET Detail
The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be ... DisGeNET Detail
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. DisGeNET Detail
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... DisGeNET Detail
TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilia... DisGeNET Detail
We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence ... DisGeNET Detail
Reduced paracrine glucagon stimulation may contribute to the impairment of beta-cell function in the... DisGeNET Detail
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903... DisGeNET Detail
Elevated hepatic glucose production and reduced insulinotropic effect of incretin hormones contribut... DisGeNET Detail
[Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity in... DisGeNET Detail
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... DisGeNET Detail
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes s... DisGeNET Detail
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7... DisGeNET Detail
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... DisGeNET Detail
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... DisGeNET Detail
Glucose Metabolism in High-Risk Subjects for Type 2 Diabetes Carrying the rs7903146 TCF7L2 Gene Vari... DisGeNET Detail
The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) v... DisGeNET Detail
The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fastin... DisGeNET Detail
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... DisGeNET Detail
Transcripts retaining exons 13 and 13a but not total TCF7L2 transcripts were significantly correlate... DisGeNET Detail
TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. DisGeNET Detail
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment fo... DisGeNET Detail
Association of variant rs7903146 (C/T) single nucleotide polymorphism of TCF7L2 gene with impairment... DisGeNET Detail
Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obes... DisGeNET Detail
We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the i... DisGeNET Detail
TCF7L2 is the strongest locus linked to type 2 diabetes that has been identified thus far, and rs790... DisGeNET Detail
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903... DisGeNET Detail
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903... DisGeNET Detail
Meta-analysis of genome-wide association data and large-scale replication identifies additional susc... DisGeNET Detail
We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and contro... DisGeNET Detail
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymo... DisGeNET Detail
The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based ... DisGeNET Detail
Genome-wide association study identifies three novel loci for type 2 diabetes. DisGeNET Detail
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined a... DisGeNET Detail
Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type... DisGeNET Detail
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... DisGeNET Detail
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 di... DisGeNET Detail
Subsequent GWAS using data from five institutions replicated the TCF7L2 gene variant (rs7903146) pre... DisGeNET Detail
Reduced paracrine glucagon stimulation may contribute to the impairment of beta-cell function in the... DisGeNET Detail
Female minor T allele carriers of rs7903146 had increased MetS risk (odds ratio [OR] 1.66, confidenc... DisGeNET Detail
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk ... DisGeNET Detail
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. DisGeNET Detail
Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via... DisGeNET Detail
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... DisGeNET Detail
rs7903146 polymorphism at transcription factor 7 like 2 gene is associated with total cholesterol an... DisGeNET Detail
TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. DisGeNET Detail
The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in sev... DisGeNET Detail
Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity ind... DisGeNET Detail
The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighted risk score of T2D ... DisGeNET Detail
Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 ... DisGeNET Detail
Meta-analysis of genome-wide association studies in African Americans provides insights into the gen... DisGeNET Detail
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes s... DisGeNET Detail
[Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.] DisGeNET Detail
Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obes... DisGeNET Detail
The present meta-analysis indicated that there were significantly associations between the TCF7L2 rs... DisGeNET Detail
In summary, high (n-6) PUFA intakes (&gt; or = 6.62% of energy intake) were associated with atheroge... DisGeNET Detail
The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighted risk score of T2D ... DisGeNET Detail
The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented i... DisGeNET Detail
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... DisGeNET Detail
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk ... DisGeNET Detail
One TCF7L2 SNP (rs7903146) showed compelling evidence of association with type 2 diabetes (admixture... DisGeNET Detail
The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in South... DisGeNET Detail
In summary, high (n-6) PUFA intakes (&gt; or = 6.62% of energy intake) were associated with atheroge... DisGeNET Detail
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... DisGeNET Detail
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. DisGeNET Detail
Our results point to a protein complex binding across rs7903146 within TCF7L2 and suggests a possibl... DisGeNET Detail
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... DisGeNET Detail
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 ... DisGeNET Detail
[Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity in... DisGeNET Detail
We genotyped the single nucleotide polymorphisms (SNP) rs7903146 of the TCF7L2 gene in 560 patients ... DisGeNET Detail
TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. DisGeNET Detail
We described for the first time a strong relationship between the TCF7L2 gene variant rs7903146 and ... DisGeNET Detail
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... DisGeNET Detail
The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significantly increased odds ra... DisGeNET Detail
Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TC... DisGeNET Detail
The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been associated with risk... DisGeNET Detail
Since the association with diabetes could be explained by effects on insulin secretion, we investiga... DisGeNET Detail
[Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity in... DisGeNET Detail
As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether inte... DisGeNET Detail
The T allele of the single-nucleotide polymorphism rs7903146 in TCF7L2 (transcription factor 7 like ... DisGeNET Detail
The present meta-analysis indicated that there were significantly associations between the TCF7L2 rs... DisGeNET Detail
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... DisGeNET Detail
[Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has bee... DisGeNET Detail
Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction... DisGeNET Detail
Our results suggest synergistic effects of WNT16a insertion and the at-risk 'T' allele of TCF7L2 (rs... DisGeNET Detail
These data provide evidence that the beneficial effect of whole-grain intake on diabetes risk is mod... DisGeNET Detail
The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significantly increased odds ra... DisGeNET Detail
In summary, high (n-6) PUFA intakes (&gt; or = 6.62% of energy intake) were associated with atheroge... DisGeNET Detail
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... DisGeNET Detail
Polymorphisms in transcription factor 7-like 2 (TCF7L2) have been associated with T2DM, with the str... DisGeNET Detail
Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associated with metabolic dis... DisGeNET Detail
Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7L2) gene with gestat... DisGeNET Detail
[Variation in the transcription factor 7-like 2 (TCF7L2) locus is associated with type 2 diabetes ac... DisGeNET Detail
Our findings provide convincing evidence that TCF7L2 genetic polymorphisms may contribute to suscept... DisGeNET Detail
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... DisGeNET Detail
This identified four loci containing variants that confer type 2 diabetes risk, in addition to confi... DisGeNET Detail
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. DisGeNET Detail
This study investigated the relationship between the TCF7L2 rs7903146 polymorphism, insulin sensitiv... DisGeNET Detail
[Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin se... DisGeNET Detail
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hyp... DisGeNET Detail
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymo... DisGeNET Detail
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903... DisGeNET Detail
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... DisGeNET Detail
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined a... DisGeNET Detail
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... DisGeNET Detail
[Healthy carriers of the T-allele of TCF7L2 rs7903146 exhibit a diminished increase of insulin secre... DisGeNET Detail
[Subsequent GWAS using data from five institutions replicated the TCF7L2 gene variant (rs7903146) pr... DisGeNET Detail
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7... DisGeNET Detail
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibilit... DisGeNET Detail
The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian populatio... DisGeNET Detail
[TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.] DisGeNET Detail
Since the association with diabetes could be explained by effects on insulin secretion, we investiga... DisGeNET Detail
These data provide evidence that the beneficial effect of whole-grain intake on diabetes risk is mod... DisGeNET Detail
SNP rs7903146 of the TCF7L2 gene was significantly associated with type 2 diabetes in the MASS-II po... DisGeNET Detail
TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilia... DisGeNET Detail
A genome-wide association study of the metabolic syndrome in Indian Asian men. DisGeNET Detail
In our study the T allele of the rs7903146 SNP in the TCF7L2 gene confers the risk of developing dia... DisGeNET Detail
Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associated with metabolic dis... DisGeNET Detail
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... DisGeNET Detail
In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 dia... DisGeNET Detail
Recently, case-control studies demonstrated that a TCF7L2 (transcription factor 7-like 2 gene) nonco... DisGeNET Detail
[These results suggest that individuals with increased genetic susceptibility to T2D have decreased ... DisGeNET Detail
The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR,... DisGeNET Detail
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... DisGeNET Detail
Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic level in humans, but ... DisGeNET Detail
There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903... DisGeNET Detail
When a stringent statistical correction for multiple testing was used, the only significant SNP was ... DisGeNET Detail
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus a... DisGeNET Detail
The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented i... DisGeNET Detail
Together, data from our study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM an... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association wit... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
This cross-sectional study aimed to investigate the independent risk factors for prediabetes, consid... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association wit... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HHEX rs1111875, IGF2BP... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... DisGeNET Detail
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... DisGeNET Detail
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... DisGeNET Detail
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... DisGeNET Detail
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... DisGeNET Detail
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... DisGeNET Detail
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... DisGeNET Detail
We genotyped the TCF7L2 single nucleotide polymorphisms rs7903146 and rs12255372 (previously associa... DisGeNET Detail
In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susce... DisGeNET Detail
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... DisGeNET Detail
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... DisGeNET Detail
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... DisGeNET Detail
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... DisGeNET Detail
In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susce... DisGeNET Detail
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... DisGeNET Detail
This study was to evaluate whether polymorphisms of TCF7L2 (rs7903146) and HHEX (rs1111875) genes re... DisGeNET Detail
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... DisGeNET Detail
These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly as... DisGeNET Detail
We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205... DisGeNET Detail
These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly as... DisGeNET Detail
We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205... DisGeNET Detail
We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marg... DisGeNET Detail
NA DisGeNET Detail
A case-control study was performed in Han Chinese subjects with normal control (n=152) and T2DM (n=2... DisGeNET Detail
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... DisGeNET Detail
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... DisGeNET Detail
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... DisGeNET Detail
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... DisGeNET Detail

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs7903146 dbSNP
Genome
hg38
Position
chr10:112,998,590-112,998,590
Variant Type
snv
Reference Allele
C
Alternative Allele
T
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs7903146
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.0452
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
758
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16760
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