Annotation Detail
Information
- Associated Genes
- CCHCR1
- Associated Variants
-
TCF7L2 c.450+33966C>T
(
ENST00000534894.5,
ENST00000355995.9,
ENST00000369397.8,
ENST00000352065.10,
ENST00000538897.5,
ENST00000627217.3,
ENST00000704414.1,
ENST00000629706.2,
ENST00000355717.9,
ENST00000545257.6,
ENST00000369395.6,
ENST00000277945.12 )
TCF7L2 c.552+9017G>T ( ENST00000538897.5, ENST00000352065.10, ENST00000369397.8, ENST00000355995.9, ENST00000534894.5, ENST00000369395.6, ENST00000277945.12, ENST00000355717.9, ENST00000545257.6, ENST00000629706.2, ENST00000627217.3, ENST00000704414.1 )
TCF7L2 c.450+33966C>T ( ENST00000277945.12, ENST00000352065.10, ENST00000355717.9, ENST00000355995.9, ENST00000369395.6, ENST00000369397.8, ENST00000534894.5, ENST00000538897.5, ENST00000545257.6, ENST00000627217.3, ENST00000629706.2, ENST00000704414.1 )
TCF7L2 c.552+9017G>T ( ENST00000277945.12, ENST00000352065.10, ENST00000355717.9, ENST00000355995.9, ENST00000369395.6, ENST00000369397.8, ENST00000534894.5, ENST00000538897.5, ENST00000545257.6, ENST00000627217.3, ENST00000629706.2, ENST00000704414.1 ) - Associated Disease
- diabetes mellitus
- Source Database
- DisGeNET
- Description
- Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for traditional diabetes risk factors (diabetes in family, waist circumference, physical activity, BMI, SBP and total and HDL-cholesterol) in both a cross-sectional and prospective setting (cross-sectional: rs12255372 OR 1.61 (1.31-1.99), rs7903146 OR 1.48 (1.20-1.83) and prospective: rs12255372 OR 1.59 (1.22-2.07), rs7903146 OR 1.47 (1.11-1.93)).
- Pubmed
- 18972257
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
- Year of publication
- 2009
Drugs