chr10:112998590:C>T Detail (hg38) (TCF7L2, LOC110121472)
Information
Genome
Assembly | Position |
---|---|
hg19 | chr10:114,758,349-114,758,349 View the variant detail on this assembly version. |
hg38 | chr10:112,998,590-112,998,590 |
HGVS
Type | Transcript | Protein |
---|---|---|
RefSeq | NM_001198528.1:c.382-41435C>T | |
NM_001146283.1:c.382-41435C>T | ||
NM_001198527.1:c.382-41435C>T |
Summary
MGeND
Clinical significance | |
Variant entry | |
GWAS entry | |
Disease area statistics | Show details |
Frequency
JP | HGVD:[No Data.] |
ToMMo:0.045 | |
NCBN:[No Data.] | |
NCBN(Hondo):[No Data.] | |
NCBN(Ryukyu):[No Data.] | |
East asia | ExAC:[No Data.] |
Prediction
ClinVar
Clinical Significance |
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Review star | ![]() |
Show details |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance | Last evaluated | Review status | Condition | Origin | Links |
---|---|---|---|---|---|
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2011-09-01 | no assertion criteria provided | Diabetes mellitus type 2, susceptibility to |
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Detail |
CIViC
[No Data.]
DisGeNET
Score | Disease name | Description | Source | Pubmed | Links |
---|---|---|---|---|---|
0.329 | Diabetes Mellitus, Non-Insulin-Dependent | In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... | BeFree | 18498634 | Detail |
0.393 | Diabetes Mellitus, Non-Insulin-Dependent | In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... | BeFree | 18498634 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... | BeFree | 18498634 | Detail |
0.330 | Diabetes Mellitus, Non-Insulin-Dependent | In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... | BeFree | 18498634 | Detail |
0.340 | Diabetes Mellitus, Non-Insulin-Dependent | In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... | BeFree | 18498634 | Detail |
0.322 | Diabetes Mellitus, Non-Insulin-Dependent | In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR =... | BeFree | 18498634 | Detail |
<0.001 | gestational diabetes | Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... | BeFree | 23761423 | Detail |
<0.001 | gestational diabetes | Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... | BeFree | 23761423 | Detail |
0.014 | gestational diabetes | Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... | BeFree | 23761423 | Detail |
<0.001 | gestational diabetes | Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... | BeFree | 23761423 | Detail |
<0.001 | gestational diabetes | Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... | BeFree | 23761423 | Detail |
<0.001 | gestational diabetes | Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6P... | BeFree | 23761423 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Given the overlap between PCOS and T2DM, we investigated the association of tran... | BeFree | 24157263 | Detail |
0.014 | gestational diabetes | Association with GDM was found for two of the most frequently replicated T2D loc... | BeFree | 25973943 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Two hundred and fifty patients identified as LADA, divided into two subgroups wi... | BeFree | 20546291 | Detail |
<0.001 | Diabetes Mellitus, Insulin-Dependent | Two hundred and fifty patients identified as LADA, divided into two subgroups wi... | BeFree | 20546291 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | TCF7L2 variants rs12255372 and rs7903146 have been associated with risk of Type ... | BeFree | 23085767 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are asso... | BeFree | 17697858 | Detail |
<0.001 | Diabetes Mellitus, Non-Insulin-Dependent | Two hundred and fifty patients identified as LADA, divided into two subgroups wi... | BeFree | 20546291 | Detail |
0.013 | Hyperlipidemia, Familial Combined | We investigated the effect of the TCF7L2 variants, rs7903146 and rs12255372, on ... | BeFree | 17972059 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene ... | BeFree | 25185411 | Detail |
0.127 | Malignant neoplasm of breast | Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association o... | BeFree | 21301999 | Detail |
0.004 | Diabetes Mellitus, Insulin-Dependent | Two hundred and fifty patients identified as LADA, divided into two subgroups wi... | BeFree | 20546291 | Detail |
0.004 | breast carcinoma | Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association o... | BeFree | 21301999 | Detail |
<0.001 | diabetes mellitus | Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when cont... | BeFree | 18972257 | Detail |
<0.001 | Diabetes | Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when cont... | BeFree | 18972257 | Detail |
0.014 | gestational diabetes | Among them, genetic variants in TCF7L2 showed the strongest association with GDM... | BeFree | 23690305 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene wit... | BeFree | 25299103 | Detail |
0.012 | hyperglycemia | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... | BeFree | 18853134 | Detail |
0.003 | hyperglycemia | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... | BeFree | 18853134 | Detail |
0.004 | pancreatic carcinoma | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | pancreatic carcinoma | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | pancreatic carcinoma | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | Malignant neoplasm of pancreas | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | Malignant neoplasm of pancreas | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | Malignant neoplasm of pancreas | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
0.003 | Malignant neoplasm of pancreas | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | pancreatic carcinoma | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | Malignant neoplasm of pancreas | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
<0.001 | pancreatic carcinoma | We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADI... | BeFree | 25516658 | Detail |
0.030 | obesity | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... | BeFree | 18853134 | Detail |
<0.001 | hyperglycemia | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... | BeFree | 18853134 | Detail |
0.336 | Diabetes Mellitus, Non-Insulin-Dependent | Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... | BeFree | 23144361 | Detail |
0.452 | Diabetes Mellitus, Non-Insulin-Dependent | Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... | BeFree | 23144361 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... | BeFree | 23144361 | Detail |
0.327 | Diabetes Mellitus, Non-Insulin-Dependent | Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be... | BeFree | 23144361 | Detail |
0.014 | gestational diabetes | Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... | BeFree | 20540670 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... | BeFree | 20540670 | Detail |
0.627 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... | BeFree | 20540670 | Detail |
0.005 | gestational diabetes | Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2... | BeFree | 20540670 | Detail |
0.447 | Diabetes Mellitus, Non-Insulin-Dependent | In fact, we evaluated the effect of seven polymorphisms in the following genes-P... | BeFree | 23249316 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | In fact, we evaluated the effect of seven polymorphisms in the following genes-P... | BeFree | 23249316 | Detail |
0.316 | Diabetes Mellitus, Non-Insulin-Dependent | In fact, we evaluated the effect of seven polymorphisms in the following genes-P... | BeFree | 23249316 | Detail |
0.094 | Diabetes Mellitus, Non-Insulin-Dependent | In fact, we evaluated the effect of seven polymorphisms in the following genes-P... | BeFree | 23249316 | Detail |
0.129 | Metabolic syndrome X | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO... | BeFree | 18853134 | Detail |
0.001 | colorectal carcinoma | Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(... | BeFree | 22419714 | Detail |
0.001 | colorectal cancer | Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(... | BeFree | 22419714 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms in TCF7L... | BeFree | 23536853 | Detail |
0.144 | Metabolic syndrome X | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... | BeFree | 21749608 | Detail |
0.101 | Metabolic syndrome X | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... | BeFree | 21749608 | Detail |
0.129 | Metabolic syndrome X | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... | BeFree | 21749608 | Detail |
0.171 | Metabolic syndrome X | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (A... | BeFree | 21749608 | Detail |
0.019 | Diabetes | These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... | BeFree | 17977958 | Detail |
0.466 | Diabetes Mellitus, Non-Insulin-Dependent | A case-control design comprising 884 type 2 diabetic patients and 513 control su... | BeFree | 19368707 | Detail |
0.018 | Diabetes | These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... | BeFree | 17977958 | Detail |
0.415 | Diabetes Mellitus, Non-Insulin-Dependent | A case-control design comprising 884 type 2 diabetic patients and 513 control su... | BeFree | 19368707 | Detail |
0.466 | Diabetes Mellitus, Non-Insulin-Dependent | Given the phenotypic overlap between PCOS and T2DM, our objective was to investi... | BeFree | 18958766 | Detail |
0.214 | Diabetes Mellitus, Non-Insulin-Dependent | A case-control design comprising 884 type 2 diabetic patients and 513 control su... | BeFree | 19368707 | Detail |
0.045 | diabetes mellitus | These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... | BeFree | 17977958 | Detail |
0.060 | diabetes mellitus | These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... | BeFree | 17977958 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Given the phenotypic overlap between PCOS and T2DM, our objective was to investi... | BeFree | 18958766 | Detail |
0.421 | Diabetes Mellitus, Non-Insulin-Dependent | In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic s... | BeFree | 22923468 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic s... | BeFree | 22923468 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | In the obese-type 2 diabetes scan, FTO variants had the strongest type 2 diabete... | BeFree | 19056611 | Detail |
<0.001 | ovarian carcinoma | The present meta-analysis indicated that there were significantly associations b... | BeFree | 23951231 | Detail |
0.005 | Impaired glucose tolerance | In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabet... | BeFree | 17593304 | Detail |
0.274 | hyperglycemia | We confirmed that the risk allele of rs7903146 is associated with hyperglycaemia... | BeFree | 19183934 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | We mapped sequence variants to open chromatin sites and found that rs7903146, a ... | BeFree | 20118932 | Detail |
0.030 | obesity | The observed trends of obesity risk alleles for risk of stroke/TIA as well as th... | BeFree | 21921652 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | In the Tunisian population, TCF7L2-rs7903146 T allele confers an increased risk ... | BeFree | 19368707 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) ... | BeFree | 19585101 | Detail |
0.374 | Diabetes Mellitus, Non-Insulin-Dependent | Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic l... | BeFree | 24925104 | Detail |
0.374 | Diabetes Mellitus, Non-Insulin-Dependent | The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been ... | BeFree | 19473183 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated... | BeFree | 24529562 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Together, data from our study show that TCF7L2-rs7903146 is associated with PDR ... | BeFree | 23434931 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabet... | BeFree | 17593304 | Detail |
0.002 | prostate carcinoma | The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominan... | BeFree | 20142250 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | There are conflicting reports about the significance of TCF7L2 single nucleotide... | BeFree | 19573884 | Detail |
0.003 | Ovarian Diseases | The findings of this systemic analysis suggest that the polymorphism of TCF7L2 r... | BeFree | 24815492 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Me... | GWASCAT | 24390345 | Detail |
0.466 | Diabetes Mellitus, Non-Insulin-Dependent | Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... | BeFree | 17020404 | Detail |
0.001 | Coronary Arteriosclerosis | TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 di... | BeFree | 19055834 | Detail |
0.274 | hyperglycemia | We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hype... | BeFree | 17065361 | Detail |
0.154 | Diabetes Mellitus, Non-Insulin-Dependent | Reduced paracrine glucagon stimulation may contribute to the impairment of beta-... | BeFree | 20107109 | Detail |
0.045 | diabetes mellitus | Human genetic studies have revealed that the T minor allele of single nucleotide... | BeFree | 25058603 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Elevated hepatic glucose production and reduced insulinotropic effect of increti... | BeFree | 19288077 | Detail |
0.002 | Weight Loss Adverse Event | [Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistanc... | GAD | 18762805 | Detail |
0.127 | hyperglycemia | Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... | BeFree | 22461567 | Detail |
0.018 | Diabetes | Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid scr... | BeFree | 19169495 | Detail |
0.018 | Diabetes | Resequencing and analysis of variation in the TCF7L2 gene in African Americans s... | BeFree | 20980453 | Detail |
0.045 | diabetes mellitus | After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... | BeFree | 22591707 | Detail |
0.018 | Diabetes | Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... | BeFree | 22461567 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Glucose Metabolism in High-Risk Subjects for Type 2 Diabetes Carrying the rs7903... | BeFree | 26046964 | Detail |
0.004 | Dyslipidemias | The results from published studies regarding association of transcription factor... | BeFree | 26576435 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 aga... | BeFree | 26576435 | Detail |
0.008 | Diabetes | After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... | BeFree | 22591707 | Detail |
0.030 | obesity | Transcripts retaining exons 13 and 13a but not total TCF7L2 transcripts were sig... | BeFree | 20097709 | Detail |
0.006 | coronary artery disease | TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severit... | BeFree | 19924244 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAM... | GWASCAT | 22693455 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Association of variant rs7903146 (C/T) single nucleotide polymorphism of TCF7L2 ... | BeFree | 24214952 | Detail |
0.030 | obesity | Relationship of transcription factor 7 like 2 gene rs7903146 variation with type... | BeFree | 23014255 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | We identify T2D-associated variants in an intergenic region of chromosome 11p12,... | GWASCAT | 17463248 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | TCF7L2 is the strongest locus linked to type 2 diabetes that has been identified... | BeFree | 19864407 | Detail |
0.018 | Diabetes | We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the ... | BeFree | 18268068 | Detail |
0.018 | Diabetes | Human genetic studies have revealed that the T minor allele of single nucleotide... | BeFree | 25058603 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Meta-analysis of genome-wide association data and large-scale replication identi... | GWASCAT | 18372903 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelan... | GWASCAT | 17460697 | Detail |
0.045 | diabetes mellitus | Our study provides the first significant evidence of association between the TCF... | BeFree | 18931037 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghan... | BeFree | 24059590 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Genome-wide association study identifies three novel loci for type 2 diabetes. | GWASCAT | 23945395 | Detail |
0.045 | diabetes mellitus | We investigated the association between the TCF7L2 rs7903146 polymorphism and in... | BeFree | 20578204 | Detail |
<0.001 | Cerebrovascular accident | Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated... | BeFree | 24529562 | Detail |
0.012 | hyperglycemia | Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... | BeFree | 22461567 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Genome-wide trans-ancestry meta-analysis provides insight into the genetic archi... | GWASCAT | 24509480 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Subsequent GWAS using data from five institutions replicated the TCF7L2 gene var... | BeFree | 22101970 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Reduced paracrine glucagon stimulation may contribute to the impairment of beta-... | BeFree | 20107109 | Detail |
0.006 | Obesity, Abdominal | Female minor T allele carriers of rs7903146 had increased MetS risk (odds ratio ... | BeFree | 21543200 | Detail |
0.045 | diabetes mellitus | In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs79031... | BeFree | 19055834 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Twelve type 2 diabetes susceptibility loci identified through large-scale associ... | GWASCAT | 20581827 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes... | BeFree | 20032493 | Detail |
0.001 | Diabetes | The FHS cohort supported these results: The rs7903146 T allele was significantly... | BeFree | 18650481 | Detail |
<0.001 | hepatitis C | rs7903146 polymorphism at transcription factor 7 like 2 gene is associated with ... | BeFree | 25353718 | Detail |
0.001 | Coronary Arteriosclerosis | TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severit... | BeFree | 19924244 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with ty... | BeFree | 20957343 | Detail |
0.003 | Overweight | Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance... | BeFree | 18762805 | Detail |
0.341 | Diabetes Mellitus, Non-Insulin-Dependent | The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighte... | BeFree | 22591707 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs79... | BeFree | 18310307 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Meta-analysis of genome-wide association studies in African Americans provides i... | GWASCAT | 25102180 | Detail |
0.045 | diabetes mellitus | Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid scr... | BeFree | 19169495 | Detail |
0.005 | Impaired glucose tolerance | [Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly... | GAD | 18611970 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Relationship of transcription factor 7 like 2 gene rs7903146 variation with type... | BeFree | 23014255 | Detail |
<0.001 | Malignant neoplasm of ovary | The present meta-analysis indicated that there were significantly associations b... | BeFree | 23951231 | Detail |
0.004 | Cardiovascular Diseases | In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were asso... | BeFree | 19141698 | Detail |
<0.001 | gestational diabetes | The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighte... | BeFree | 22591707 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly... | BeFree | 25498973 | Detail |
0.001 | diabetes mellitus | The FHS cohort supported these results: The rs7903146 T allele was significantly... | BeFree | 18650481 | Detail |
0.018 | Diabetes | In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs79031... | BeFree | 19055834 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | One TCF7L2 SNP (rs7903146) showed compelling evidence of association with type 2... | BeFree | 18443202 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabet... | BeFree | 25627047 | Detail |
0.129 | Metabolic syndrome X | In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were asso... | BeFree | 19141698 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... | BeFree | 21169132 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Genome-wide association analysis identifies loci for type 2 diabetes and triglyc... | GWASCAT | 17463246 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Our results point to a protein complex binding across rs7903146 within TCF7L2 an... | BeFree | 24667787 | Detail |
<0.001 | Diabetes | The FHS cohort supported these results: The rs7903146 T allele was significantly... | BeFree | 18650481 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Confirmation of multiple risk Loci and genetic impacts by a genome-wide associat... | GWASCAT | 19401414 | Detail |
0.003 | Overweight | [Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistanc... | GAD | 18762805 | Detail |
0.001 | Coronary heart disease | We genotyped the single nucleotide polymorphisms (SNP) rs7903146 of the TCF7L2 g... | BeFree | 19055834 | Detail |
0.009 | Coronary heart disease | TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severit... | BeFree | 19924244 | Detail |
0.004 | Cardiovascular Diseases | We described for the first time a strong relationship between the TCF7L2 gene va... | BeFree | 24574000 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... | BeFree | 17020404 | Detail |
0.018 | Diabetes | The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significant... | BeFree | 20437825 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Association of the rs7903146 single nucleotide polymorphism at the Transcription... | BeFree | 23295285 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been ... | BeFree | 19473183 | Detail |
0.295 | diabetes mellitus | Since the association with diabetes could be explained by effects on insulin sec... | BeFree | 21349175 | Detail |
0.024 | Insulin resistance | [Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistanc... | GAD | 18762805 | Detail |
0.095 | Diabetes Mellitus, Non-Insulin-Dependent | As TCF7L2 rs7903146 has been associated with diminished incretin effect we inves... | BeFree | 22782288 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The T allele of the single-nucleotide polymorphism rs7903146 in TCF7L2 (transcri... | BeFree | 18762805 | Detail |
0.004 | Malignant tumor of colon | The present meta-analysis indicated that there were significantly associations b... | BeFree | 23951231 | Detail |
0.393 | Diabetes Mellitus, Non-Insulin-Dependent | Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... | BeFree | 21169132 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | [Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits... | GAD | 21873549 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: g... | BeFree | 19149908 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Our results suggest synergistic effects of WNT16a insertion and the at-risk 'T' ... | BeFree | 23617586 | Detail |
0.045 | diabetes mellitus | These data provide evidence that the beneficial effect of whole-grain intake on ... | BeFree | 19149908 | Detail |
0.045 | diabetes mellitus | The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significant... | BeFree | 20437825 | Detail |
0.004 | Dyslipidemias | In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were asso... | BeFree | 19141698 | Detail |
0.466 | Diabetes Mellitus, Non-Insulin-Dependent | Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... | BeFree | 21169132 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Polymorphisms in transcription factor 7-like 2 (TCF7L2) have been associated wit... | BeFree | 25117344 | Detail |
<0.001 | metabolic disturbance | Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associate... | BeFree | 25353718 | Detail |
0.014 | gestational diabetes | Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7... | BeFree | 23855352 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | [Variation in the transcription factor 7-like 2 (TCF7L2) locus is associated wit... | GAD | 20980453 | Detail |
0.003 | Ovarian Diseases | Our findings provide convincing evidence that TCF7L2 genetic polymorphisms may c... | BeFree | 24611738 | Detail |
<0.001 | diabetes mellitus | The FHS cohort supported these results: The rs7903146 T allele was significantly... | BeFree | 18650481 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | This identified four loci containing variants that confer type 2 diabetes risk, ... | GWASCAT | 17293876 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incre... | BeFree | 19934000 | Detail |
0.001 | Metabolic syndrome X | This study investigated the relationship between the TCF7L2 rs7903146 polymorphi... | BeFree | 21543200 | Detail |
0.024 | Insulin resistance | [Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clam... | GAD | 19573884 | Detail |
0.030 | obesity | TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a ... | BeFree | 20032493 | Detail |
0.018 | Diabetes | Our study provides the first significant evidence of association between the TCF... | BeFree | 18931037 | Detail |
0.045 | diabetes mellitus | We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the ... | BeFree | 18268068 | Detail |
0.045 | diabetes mellitus | Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the a... | BeFree | 22461567 | Detail |
0.018 | Diabetes | We investigated the association between the TCF7L2 rs7903146 polymorphism and in... | BeFree | 20578204 | Detail |
0.025 | diabetes mellitus | After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... | BeFree | 22591707 | Detail |
0.024 | Insulin resistance | [Healthy carriers of the T-allele of TCF7L2 rs7903146 exhibit a diminished incre... | GAD | 20107109 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | [Subsequent GWAS using data from five institutions replicated the TCF7L2 gene va... | GAD | 22101970 | Detail |
0.045 | diabetes mellitus | Resequencing and analysis of variation in the TCF7L2 gene in African Americans s... | BeFree | 20980453 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Genome-wide association study identifies a novel locus contributing to type 2 di... | GWASCAT | 23300278 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in a... | BeFree | 25491720 | Detail |
0.006 | coronary artery disease | [TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severi... | GAD | 19924244 | Detail |
0.080 | Diabetes | Since the association with diabetes could be explained by effects on insulin sec... | BeFree | 21349175 | Detail |
0.018 | Diabetes | These data provide evidence that the beneficial effect of whole-grain intake on ... | BeFree | 19149908 | Detail |
<0.001 | Diabetes Mellitus, Non-Insulin-Dependent | SNP rs7903146 of the TCF7L2 gene was significantly associated with type 2 diabet... | BeFree | 19055834 | Detail |
0.009 | Coronary heart disease | TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 di... | BeFree | 19055834 | Detail |
0.129 | Metabolic syndrome X | A genome-wide association study of the metabolic syndrome in Indian Asian men. | GWASCAT | 20694148 | Detail |
0.001 | Diabetic Nephropathy | In our study the T allele of the rs7903146 SNP in the TCF7L2 gene confers the ri... | BeFree | 24574000 | Detail |
0.004 | Cardiovascular Diseases | Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associate... | BeFree | 25353718 | Detail |
0.018 | Diabetes | After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs80501... | BeFree | 22591707 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk f... | BeFree | 19713311 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Recently, case-control studies demonstrated that a TCF7L2 (transcription factor ... | BeFree | 17065361 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | [These results suggest that individuals with increased genetic susceptibility to... | GAD | 20203524 | Detail |
0.007 | Malignant neoplasm of prostate | The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominan... | BeFree | 20142250 | Detail |
0.393 | Diabetes Mellitus, Non-Insulin-Dependent | Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs79... | BeFree | 17020404 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic l... | BeFree | 24925104 | Detail |
0.374 | Diabetes Mellitus, Non-Insulin-Dependent | There are conflicting reports about the significance of TCF7L2 single nucleotide... | BeFree | 19573884 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | When a stringent statistical correction for multiple testing was used, the only ... | GWASCAT | 17668382 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Genome-wide association study for type 2 diabetes in Indians identifies a new su... | GWASCAT | 23209189 | Detail |
<0.001 | hereditary multiple exostoses | The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly... | BeFree | 25498973 | Detail |
0.008 | proliferative diabetic retinopathy | Together, data from our study show that TCF7L2-rs7903146 is associated with PDR ... | BeFree | 23434931 | Detail |
0.340 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
0.393 | Diabetes Mellitus, Non-Insulin-Dependent | Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nom... | BeFree | 20161779 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
0.466 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
0.055 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
<0.001 | prediabetes syndrome | This cross-sectional study aimed to investigate the independent risk factors for... | BeFree | 26334876 | Detail |
0.042 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
0.029 | Diabetes Mellitus, Non-Insulin-Dependent | Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nom... | BeFree | 20161779 | Detail |
0.121 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
0.009 | gestational diabetes | 13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HH... | BeFree | 22591707 | Detail |
0.090 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
0.025 | Diabetes Mellitus, Non-Insulin-Dependent | Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (H... | BeFree | 25839936 | Detail |
0.005 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
0.123 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
0.002 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
0.009 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
0.126 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
0.145 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | We genotyped the TCF7L2 single nucleotide polymorphisms rs7903146 and rs12255372... | BeFree | 19183934 | Detail |
0.214 | Diabetes Mellitus, Non-Insulin-Dependent | In addition to these polymorphisms, meta-analysis confirmed the association of t... | BeFree | 19033397 | Detail |
0.006 | obesity | In this study, we asked whether the co-occurrence of risk alleles in or near fiv... | BeFree | 24062323 | Detail |
0.003 | Impaired glucose tolerance | In this study, we asked whether the co-occurrence of risk alleles in or near fiv... | BeFree | 24062323 | Detail |
0.214 | Diabetes Mellitus, Non-Insulin-Dependent | In this study, we asked whether the co-occurrence of risk alleles in or near fiv... | BeFree | 24062323 | Detail |
0.011 | obesity | In this study, we asked whether the co-occurrence of risk alleles in or near fiv... | BeFree | 24062323 | Detail |
0.466 | Diabetes Mellitus, Non-Insulin-Dependent | In addition to these polymorphisms, meta-analysis confirmed the association of t... | BeFree | 19033397 | Detail |
0.329 | Diabetes Mellitus, Non-Insulin-Dependent | In this study, we asked whether the co-occurrence of risk alleles in or near fiv... | BeFree | 24062323 | Detail |
0.162 | polycystic ovary syndrome | This study was to evaluate whether polymorphisms of TCF7L2 (rs7903146) and HHEX ... | BeFree | 20041287 | Detail |
0.007 | Impaired glucose tolerance | In this study, we asked whether the co-occurrence of risk alleles in or near fiv... | BeFree | 24062323 | Detail |
0.006 | coronary artery disease | These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 ... | BeFree | 21423583 | Detail |
0.045 | diabetes mellitus | We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, r... | BeFree | 18291022 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 ... | BeFree | 21423583 | Detail |
0.018 | Diabetes | We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, r... | BeFree | 18291022 | Detail |
<0.001 | Diabetes Mellitus, Non-Insulin-Dependent | We compared genotype frequencies in subjects with type 2 diabetes with those wit... | BeFree | 16936218 | Detail |
0.614 | Diabetes Mellitus, Non-Insulin-Dependent | NA | CLINVAR | Detail | |
0.340 | Diabetes Mellitus, Non-Insulin-Dependent | A case-control study was performed in Han Chinese subjects with normal control (... | BeFree | 21437630 | Detail |
0.136 | colorectal cancer | A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... | BeFree | 22419714 | Detail |
<0.001 | colorectal carcinoma | A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... | BeFree | 22419714 | Detail |
0.011 | colorectal carcinoma | A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... | BeFree | 22419714 | Detail |
<0.001 | colorectal cancer | A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T alle... | BeFree | 22419714 | Detail |
Annotation
Annotations
Descrption | Source | Links |
---|---|---|
NM_001367943.1(TCF7L2):c.450+33966C>T AND Diabetes mellitus type 2, susceptibility to | ClinVar | Detail |
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... | DisGeNET | Detail |
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... | DisGeNET | Detail |
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... | DisGeNET | Detail |
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... | DisGeNET | Detail |
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... | DisGeNET | Detail |
In obese subjects, associations with T2D were detected with PPARG Pro12Ala (OR = 0.73, P = 0.004), A... | DisGeNET | Detail |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... | DisGeNET | Detail |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... | DisGeNET | Detail |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... | DisGeNET | Detail |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... | DisGeNET | Detail |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... | DisGeNET | Detail |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR... | DisGeNET | Detail |
Given the overlap between PCOS and T2DM, we investigated the association of transcription factor-7-l... | DisGeNET | Detail |
Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotyp... | DisGeNET | Detail |
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (< or = 32... | DisGeNET | Detail |
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (< or = 32... | DisGeNET | Detail |
TCF7L2 variants rs12255372 and rs7903146 have been associated with risk of Type 2 diabetes. | DisGeNET | Detail |
The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 d... | DisGeNET | Detail |
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (< or = 32... | DisGeNET | Detail |
We investigated the effect of the TCF7L2 variants, rs7903146 and rs12255372, on FCHL and its compone... | DisGeNET | Detail |
Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes... | DisGeNET | Detail |
Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(... | DisGeNET | Detail |
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (< or = 32... | DisGeNET | Detail |
Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(... | DisGeNET | Detail |
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for tradition... | DisGeNET | Detail |
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for tradition... | DisGeNET | Detail |
Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95%... | DisGeNET | Detail |
Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in... | DisGeNET | Detail |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... | DisGeNET | Detail |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADR... | DisGeNET | Detail |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... | DisGeNET | Detail |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... | DisGeNET | Detail |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... | DisGeNET | Detail |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... | DisGeNET | Detail |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... | DisGeNET | Detail |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D... | DisGeNET | Detail |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... | DisGeNET | Detail |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... | DisGeNET | Detail |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... | DisGeNET | Detail |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gen... | DisGeNET | Detail |
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... | DisGeNET | Detail |
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... | DisGeNET | Detail |
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... | DisGeNET | Detail |
In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNF... | DisGeNET | Detail |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08... | DisGeNET | Detail |
Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(trend) = 0.02), wher... | DisGeNET | Detail |
Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(trend) = 0.02), wher... | DisGeNET | Detail |
Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms in TCF7L2 with type 2 diabet... | DisGeNET | Detail |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... | DisGeNET | Detail |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... | DisGeNET | Detail |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... | DisGeNET | Detail |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3)... | DisGeNET | Detail |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... | DisGeNET | Detail |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the... | DisGeNET | Detail |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... | DisGeNET | Detail |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the... | DisGeNET | Detail |
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF... | DisGeNET | Detail |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the... | DisGeNET | Detail |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... | DisGeNET | Detail |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... | DisGeNET | Detail |
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF... | DisGeNET | Detail |
In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7... | DisGeNET | Detail |
In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7... | DisGeNET | Detail |
In the obese-type 2 diabetes scan, FTO variants had the strongest type 2 diabetes effect (rs8050136:... | DisGeNET | Detail |
The present meta-analysis indicated that there were significantly associations between the TCF7L2 rs... | DisGeNET | Detail |
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been a... | DisGeNET | Detail |
We confirmed that the risk allele of rs7903146 is associated with hyperglycaemia and a higher proins... | DisGeNET | Detail |
We mapped sequence variants to open chromatin sites and found that rs7903146, a TCF7L2 intronic vari... | DisGeNET | Detail |
The observed trends of obesity risk alleles for risk of stroke/TIA as well as the possible sex-speci... | DisGeNET | Detail |
In the Tunisian population, TCF7L2-rs7903146 T allele confers an increased risk of developing T2D as... | DisGeNET | Detail |
A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) was associated with ... | DisGeNET | Detail |
Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic level in humans, but ... | DisGeNET | Detail |
The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been associated with risk... | DisGeNET | Detail |
Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type... | DisGeNET | Detail |
Together, data from our study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM an... | DisGeNET | Detail |
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been a... | DisGeNET | Detail |
The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR,... | DisGeNET | Detail |
There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903... | DisGeNET | Detail |
The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be ... | DisGeNET | Detail |
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. | DisGeNET | Detail |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... | DisGeNET | Detail |
TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilia... | DisGeNET | Detail |
We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence ... | DisGeNET | Detail |
Reduced paracrine glucagon stimulation may contribute to the impairment of beta-cell function in the... | DisGeNET | Detail |
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903... | DisGeNET | Detail |
Elevated hepatic glucose production and reduced insulinotropic effect of incretin hormones contribut... | DisGeNET | Detail |
[Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity in... | DisGeNET | Detail |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... | DisGeNET | Detail |
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes s... | DisGeNET | Detail |
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7... | DisGeNET | Detail |
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... | DisGeNET | Detail |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... | DisGeNET | Detail |
Glucose Metabolism in High-Risk Subjects for Type 2 Diabetes Carrying the rs7903146 TCF7L2 Gene Vari... | DisGeNET | Detail |
The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) v... | DisGeNET | Detail |
The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fastin... | DisGeNET | Detail |
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... | DisGeNET | Detail |
Transcripts retaining exons 13 and 13a but not total TCF7L2 transcripts were significantly correlate... | DisGeNET | Detail |
TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. | DisGeNET | Detail |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment fo... | DisGeNET | Detail |
Association of variant rs7903146 (C/T) single nucleotide polymorphism of TCF7L2 gene with impairment... | DisGeNET | Detail |
Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obes... | DisGeNET | Detail |
We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the i... | DisGeNET | Detail |
TCF7L2 is the strongest locus linked to type 2 diabetes that has been identified thus far, and rs790... | DisGeNET | Detail |
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903... | DisGeNET | Detail |
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903... | DisGeNET | Detail |
Meta-analysis of genome-wide association data and large-scale replication identifies additional susc... | DisGeNET | Detail |
We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and contro... | DisGeNET | Detail |
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymo... | DisGeNET | Detail |
The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based ... | DisGeNET | Detail |
Genome-wide association study identifies three novel loci for type 2 diabetes. | DisGeNET | Detail |
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined a... | DisGeNET | Detail |
Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type... | DisGeNET | Detail |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... | DisGeNET | Detail |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 di... | DisGeNET | Detail |
Subsequent GWAS using data from five institutions replicated the TCF7L2 gene variant (rs7903146) pre... | DisGeNET | Detail |
Reduced paracrine glucagon stimulation may contribute to the impairment of beta-cell function in the... | DisGeNET | Detail |
Female minor T allele carriers of rs7903146 had increased MetS risk (odds ratio [OR] 1.66, confidenc... | DisGeNET | Detail |
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk ... | DisGeNET | Detail |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. | DisGeNET | Detail |
Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via... | DisGeNET | Detail |
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... | DisGeNET | Detail |
rs7903146 polymorphism at transcription factor 7 like 2 gene is associated with total cholesterol an... | DisGeNET | Detail |
TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. | DisGeNET | Detail |
The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in sev... | DisGeNET | Detail |
Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity ind... | DisGeNET | Detail |
The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighted risk score of T2D ... | DisGeNET | Detail |
Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 ... | DisGeNET | Detail |
Meta-analysis of genome-wide association studies in African Americans provides insights into the gen... | DisGeNET | Detail |
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes s... | DisGeNET | Detail |
[Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.] | DisGeNET | Detail |
Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obes... | DisGeNET | Detail |
The present meta-analysis indicated that there were significantly associations between the TCF7L2 rs... | DisGeNET | Detail |
In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atheroge... | DisGeNET | Detail |
The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighted risk score of T2D ... | DisGeNET | Detail |
The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented i... | DisGeNET | Detail |
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... | DisGeNET | Detail |
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk ... | DisGeNET | Detail |
One TCF7L2 SNP (rs7903146) showed compelling evidence of association with type 2 diabetes (admixture... | DisGeNET | Detail |
The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in South... | DisGeNET | Detail |
In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atheroge... | DisGeNET | Detail |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... | DisGeNET | Detail |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. | DisGeNET | Detail |
Our results point to a protein complex binding across rs7903146 within TCF7L2 and suggests a possibl... | DisGeNET | Detail |
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... | DisGeNET | Detail |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 ... | DisGeNET | Detail |
[Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity in... | DisGeNET | Detail |
We genotyped the single nucleotide polymorphisms (SNP) rs7903146 of the TCF7L2 gene in 560 patients ... | DisGeNET | Detail |
TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. | DisGeNET | Detail |
We described for the first time a strong relationship between the TCF7L2 gene variant rs7903146 and ... | DisGeNET | Detail |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... | DisGeNET | Detail |
The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significantly increased odds ra... | DisGeNET | Detail |
Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TC... | DisGeNET | Detail |
The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been associated with risk... | DisGeNET | Detail |
Since the association with diabetes could be explained by effects on insulin secretion, we investiga... | DisGeNET | Detail |
[Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity in... | DisGeNET | Detail |
As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether inte... | DisGeNET | Detail |
The T allele of the single-nucleotide polymorphism rs7903146 in TCF7L2 (transcription factor 7 like ... | DisGeNET | Detail |
The present meta-analysis indicated that there were significantly associations between the TCF7L2 rs... | DisGeNET | Detail |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... | DisGeNET | Detail |
[Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has bee... | DisGeNET | Detail |
Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction... | DisGeNET | Detail |
Our results suggest synergistic effects of WNT16a insertion and the at-risk 'T' allele of TCF7L2 (rs... | DisGeNET | Detail |
These data provide evidence that the beneficial effect of whole-grain intake on diabetes risk is mod... | DisGeNET | Detail |
The carriers of the TT-genotype of TCF7L2 rs7903146 polymorphism had significantly increased odds ra... | DisGeNET | Detail |
In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atheroge... | DisGeNET | Detail |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... | DisGeNET | Detail |
Polymorphisms in transcription factor 7-like 2 (TCF7L2) have been associated with T2DM, with the str... | DisGeNET | Detail |
Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associated with metabolic dis... | DisGeNET | Detail |
Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7L2) gene with gestat... | DisGeNET | Detail |
[Variation in the transcription factor 7-like 2 (TCF7L2) locus is associated with type 2 diabetes ac... | DisGeNET | Detail |
Our findings provide convincing evidence that TCF7L2 genetic polymorphisms may contribute to suscept... | DisGeNET | Detail |
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with low... | DisGeNET | Detail |
This identified four loci containing variants that confer type 2 diabetes risk, in addition to confi... | DisGeNET | Detail |
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. | DisGeNET | Detail |
This study investigated the relationship between the TCF7L2 rs7903146 polymorphism, insulin sensitiv... | DisGeNET | Detail |
[Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin se... | DisGeNET | Detail |
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hyp... | DisGeNET | Detail |
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymo... | DisGeNET | Detail |
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903... | DisGeNET | Detail |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglyce... | DisGeNET | Detail |
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined a... | DisGeNET | Detail |
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... | DisGeNET | Detail |
[Healthy carriers of the T-allele of TCF7L2 rs7903146 exhibit a diminished increase of insulin secre... | DisGeNET | Detail |
[Subsequent GWAS using data from five institutions replicated the TCF7L2 gene variant (rs7903146) pr... | DisGeNET | Detail |
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7... | DisGeNET | Detail |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibilit... | DisGeNET | Detail |
The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian populatio... | DisGeNET | Detail |
[TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.] | DisGeNET | Detail |
Since the association with diabetes could be explained by effects on insulin secretion, we investiga... | DisGeNET | Detail |
These data provide evidence that the beneficial effect of whole-grain intake on diabetes risk is mod... | DisGeNET | Detail |
SNP rs7903146 of the TCF7L2 gene was significantly associated with type 2 diabetes in the MASS-II po... | DisGeNET | Detail |
TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilia... | DisGeNET | Detail |
A genome-wide association study of the metabolic syndrome in Indian Asian men. | DisGeNET | Detail |
In our study the T allele of the rs7903146 SNP in the TCF7L2 gene confers the risk of developing dia... | DisGeNET | Detail |
Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associated with metabolic dis... | DisGeNET | Detail |
After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants signific... | DisGeNET | Detail |
In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 dia... | DisGeNET | Detail |
Recently, case-control studies demonstrated that a TCF7L2 (transcription factor 7-like 2 gene) nonco... | DisGeNET | Detail |
[These results suggest that individuals with increased genetic susceptibility to T2D have decreased ... | DisGeNET | Detail |
The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR,... | DisGeNET | Detail |
Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) hav... | DisGeNET | Detail |
Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic level in humans, but ... | DisGeNET | Detail |
There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903... | DisGeNET | Detail |
When a stringent statistical correction for multiple testing was used, the only significant SNP was ... | DisGeNET | Detail |
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus a... | DisGeNET | Detail |
The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented i... | DisGeNET | Detail |
Together, data from our study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM an... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association wit... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
This cross-sectional study aimed to investigate the independent risk factors for prediabetes, consid... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association wit... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HHEX rs1111875, IGF2BP... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ1... | DisGeNET | Detail |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
We genotyped the TCF7L2 single nucleotide polymorphisms rs7903146 and rs12255372 (previously associa... | DisGeNET | Detail |
In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susce... | DisGeNET | Detail |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... | DisGeNET | Detail |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... | DisGeNET | Detail |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... | DisGeNET | Detail |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... | DisGeNET | Detail |
In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susce... | DisGeNET | Detail |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... | DisGeNET | Detail |
This study was to evaluate whether polymorphisms of TCF7L2 (rs7903146) and HHEX (rs1111875) genes re... | DisGeNET | Detail |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating i... | DisGeNET | Detail |
These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly as... | DisGeNET | Detail |
We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205... | DisGeNET | Detail |
These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly as... | DisGeNET | Detail |
We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205... | DisGeNET | Detail |
We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marg... | DisGeNET | Detail |
NA | DisGeNET | Detail |
A case-control study was performed in Han Chinese subjects with normal control (n=152) and T2DM (n=2... | DisGeNET | Detail |
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... | DisGeNET | Detail |
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... | DisGeNET | Detail |
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... | DisGeNET | Detail |
A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated wi... | DisGeNET | Detail |
Overlapped Transcript
Gene | Transcript ID | Chromosome | Start | Stop | Links |
---|
- Gene
- -
- dbSNP
- rs7903146 dbSNP
- Genome
- hg38
- Position
- chr10:112,998,590-112,998,590
- Variant Type
- snv
- Reference Allele
- C
- Alternative Allele
- T
- ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- PASS
- Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- rs7903146
- Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 0.0452
- Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 758
- Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 16760
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