Annotation Detail
Information
- Associated Genes
- TCF7L2
- Associated Variants
-
TCF7L2 c.450+33966C>T
(
ENST00000534894.5,
ENST00000355995.9,
ENST00000369397.8,
ENST00000352065.10,
ENST00000538897.5,
ENST00000627217.3,
ENST00000704414.1,
ENST00000629706.2,
ENST00000355717.9,
ENST00000545257.6,
ENST00000369395.6,
ENST00000277945.12 )
TCF7L2 c.450+33966C>T ( ENST00000277945.12, ENST00000352065.10, ENST00000355717.9, ENST00000355995.9, ENST00000369395.6, ENST00000369397.8, ENST00000534894.5, ENST00000538897.5, ENST00000545257.6, ENST00000627217.3, ENST00000629706.2, ENST00000704414.1 ) - Associated Disease
- Diabetes Mellitus, Non-Insulin-Dependent
- Source Database
- DisGeNET
- Description
- Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 x 10(-7)), compared with control subjects (44.8%) and type 1 diabetic subjects (43.3%).
- Pubmed
- 18310307
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.613988408391434
- Year of publication
- 2008
Drugs