chr4:74606024:A>T Detail (hg19) (CXCL8)

Information

Genome

Assembly Position
hg19 chr4:74,606,024-74,606,024
hg38 chr4:73,740,307-73,740,307 View the variant detail on this assembly version.

HGVS

[No Data.]
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:[No Data.]
ToMMo:0.679
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:[No Data.]

Prediction

ClinVar

Clinical Significance other
Review star
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
other 2022-12-10 no assertion criteria provided germline Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.005 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
0.001 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
<0.001 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
0.002 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
<0.001 Wheezing IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were asso... BeFree 25326706 Detail
<0.001 Wheezing IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were asso... BeFree 25326706 Detail
<0.001 Wheezing IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were asso... BeFree 25326706 Detail
0.001 Wheezing IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were asso... BeFree 25326706 Detail
<0.001 Wheezing IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were asso... BeFree 25326706 Detail
<0.001 breast carcinoma To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-9... BeFree 25559835 Detail
0.003 Malignant neoplasm of breast To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-9... BeFree 25559835 Detail
<0.001 Wheezing IL8-rs4073AT, VEGFA-rs2146323AA and NFKBIA-rs2233419AG were associated with a si... BeFree 25326706 Detail
<0.001 Wheezing IL8-rs4073AT, VEGFA-rs2146323AA and NFKBIA-rs2233419AG were associated with a si... BeFree 25326706 Detail
<0.001 Wheezing IL8-rs4073AT, VEGFA-rs2146323AA and NFKBIA-rs2233419AG were associated with a si... BeFree 25326706 Detail
<0.001 lymphoma In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p... BeFree 25294155 Detail
0.004 lymphoma In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p... BeFree 25294155 Detail
0.001 Severe Sepsis Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were a... BeFree 25000179 Detail
<0.001 Severe Sepsis Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were a... BeFree 25000179 Detail
0.061 tuberculosis A higher prevalence of purified protein derivative reactivity was associated wit... BeFree 25199010 Detail
0.011 tuberculosis A higher prevalence of purified protein derivative reactivity was associated wit... BeFree 25199010 Detail
0.019 prostate carcinoma After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs... BeFree 20431935 Detail
<0.001 tuberculosis A higher prevalence of purified protein derivative reactivity was associated wit... BeFree 25199010 Detail
0.025 Malignant neoplasm of prostate After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs... BeFree 20431935 Detail
0.015 stomach carcinoma The aim of this study was to investigate the association between the IL-8 (rs407... BeFree 23558993 Detail
0.064 tuberculosis A higher prevalence of purified protein derivative reactivity was associated wit... BeFree 25199010 Detail
0.003 Chronic Periodontitis Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic peri... BeFree 21091348 Detail
<0.001 Vesico-Ureteral Reflux Following the elimination of vesicoureteral reflux, which is a significant risk ... BeFree 21042230 Detail
0.044 Malignant neoplasm of stomach The aim of this study was to investigate the association between the IL-8 (rs407... BeFree 23558993 Detail
0.048 Malignant neoplasm of prostate After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs... BeFree 20431935 Detail
0.002 Idiopathic Pulmonary Fibrosis A promoter SNP rs4073T&gt;A in the common allele of the interleukin 8 gene is as... BeFree 21649933 Detail
0.029 Malignant neoplasm of lung [When numeric scores were assigned to both the SNP and demographic data, and seq... GAD 19789190 Detail
0.011 prostate carcinoma After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs... BeFree 20431935 Detail
0.004 Clostridium difficile infection Is the interleukin 8 promoter polymorphism rs4073/-251T &gt;A associated with Cl... BeFree 24633688 Detail
Annotation

Annotations

DescrptionSourceLinks
NC_000004.12:g.73740307A>T AND Cholangiocarcinoma ClinVar Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were associated with a signif... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were associated with a signif... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were associated with a signif... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were associated with a signif... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs833058CT, MBL2-rs1800450CT and IKBKB-rs3747811AT were associated with a signif... DisGeNET Detail
To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C&gt;T (rs2233406)... DisGeNET Detail
To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C&gt;T (rs2233406)... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs2146323AA and NFKBIA-rs2233419AG were associated with a significantly increase... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs2146323AA and NFKBIA-rs2233419AG were associated with a significantly increase... DisGeNET Detail
IL8-rs4073AT, VEGFA-rs2146323AA and NFKBIA-rs2233419AG were associated with a significantly increase... DisGeNET Detail
In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p = 0.006) showed nom... DisGeNET Detail
In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p = 0.006) showed nom... DisGeNET Detail
Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were associated with a sig... DisGeNET Detail
Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were associated with a sig... DisGeNET Detail
A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG ... DisGeNET Detail
A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG ... DisGeNET Detail
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not signi... DisGeNET Detail
A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG ... DisGeNET Detail
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not signi... DisGeNET Detail
The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene poly... DisGeNET Detail
A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG ... DisGeNET Detail
Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis. DisGeNET Detail
Following the elimination of vesicoureteral reflux, which is a significant risk factor for severe pa... DisGeNET Detail
The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene poly... DisGeNET Detail
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not signi... DisGeNET Detail
A promoter SNP rs4073T&gt;A in the common allele of the interleukin 8 gene is associated with the de... DisGeNET Detail
[When numeric scores were assigned to both the SNP and demographic data, and sequentially combined b... DisGeNET Detail
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not signi... DisGeNET Detail
Is the interleukin 8 promoter polymorphism rs4073/-251T &gt;A associated with Clostridium difficile ... DisGeNET Detail
Gene
-
Genome
hg19
Position
chr4:74,606,024-74,606,024
Variant Type
snv
Reference Allele
A
Alternative Allele
T
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs4073
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.6786
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
11374
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16760
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