chr6:38675925:> Detail (hg38)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr6:38,643,701-38,670,921 |
| hg38 | chr6:38,675,925-38,703,145 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.002 | Coronary Arteriosclerosis | NA | GAD | Detail | |
| 0.120 | depressive disorder | NA | CTD_human | Detail | |
| 0.003 | Diabetes | Glo1 inducers are in development to sustain healthy aging and for treatment of v... | BeFree | 24646254 | Detail |
| 0.004 | diabetes mellitus | Glo1 inducers are in development to sustain healthy aging and for treatment of v... | BeFree | 24646254 | Detail |
| <0.001 | Diabetes Mellitus, Insulin-Dependent | NA | BeFree | Detail | |
| 0.006 | Diabetes Mellitus, Non-Insulin-Dependent | NA | BeFree,GAD | Detail | |
| <0.001 | Glioma | NA | BeFree | Detail | |
| <0.001 | Hodgkin Disease | NA | BeFree | Detail | |
| <0.001 | Huntington disease | NA | BeFree | Detail | |
| <0.001 | hyperglycemia | NA | BeFree | Detail | |
| <0.001 | ischemia | NA | BeFree | Detail | |
| 0.005 | Kidney Failure, Chronic | NA | GAD | Detail | |
| <0.001 | leukemia | NA | BeFree | Detail | |
| <0.001 | myeloid leukemia | NA | BeFree | Detail | |
| 0.002 | Liver Cirrhosis, Alcoholic | NA | GAD | Detail | |
| <0.001 | Malignant neoplasm of stomach | Integrated genomic and functional analyses reveal glyoxalase I as a novel metabo... | BeFree | 24662817 | Detail |
| 0.120 | melanoma | NA | BeFree,CTD_human | Detail | |
| 0.005 | multiple sclerosis | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Neoplasm Metastasis | NA | BeFree | Detail | |
| <0.001 | nephrotic syndrome | NA | BeFree | Detail | |
| <0.001 | obesity | The prevalence of GLO1 copy number increase in the human population appears to b... | BeFree | 24646268 | Detail |
| 0.002 | Pancreatic Neoplasm | NA | GAD | Detail | |
| 0.005 | panic disorder | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | Prostatic Neoplasms | NA | LHGDN | Detail | |
| <0.001 | schizophrenia | Here, we investigated the role of the glyoxalase system in schizophrenia by perf... | BeFree | 25645869 | Detail |
| 0.002 | Tobacco use disorder | NA | GAD | Detail | |
| 0.010 | tuberculosis | NA | GAD,LHGDN | Detail | |
| 0.002 | uremia | NA | GAD | Detail | |
| 0.003 | Vascular Diseases | NA | BeFree,GAD | Detail | |
| <0.001 | Panic Attacks | NA | BeFree | Detail | |
| <0.001 | Ataxia, Spinocerebellar | NA | BeFree | Detail | |
| <0.001 | Vascular anomaly | Polymorphisms in the genes encoding for enzymes involved in the antioxidant syst... | BeFree | 26122242 | Detail |
| <0.001 | Adenocarcinoma, Clear Cell | NA | BeFree | Detail | |
| 0.006 | Diabetes Mellitus, Non-Insulin-Dependent | Here, we examine a possible association of a single nucleotide polymorphism of g... | BeFree | 23775136 | Detail |
| 0.126 | autistic disorder | Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates... | BeFree | 21491613 | Detail |
| 0.120 | Squamous cell carcinoma of esophagus | NA | CTD_human | Detail | |
| <0.001 | Steroid-sensitive nephrotic syndrome | NA | BeFree | Detail | |
| 0.002 | Metabolic syndrome X | NA | GAD | Detail | |
| <0.001 | Neurodegenerative Disorders | NA | BeFree | Detail | |
| 0.003 | Mood Disorders | NA | BeFree,LHGDN | Detail | |
| <0.001 | Hodgkin Disease | The A419C (E111A) polymorphism of the GLO I gene is associated with vascular dis... | BeFree | 20185929 | Detail |
| 0.004 | diabetes mellitus | In a multiple regression analysis with GLO1 activity as the dependent variable, ... | BeFree | 23360186 | Detail |
| 0.003 | Vascular Diseases | The A419C (E111A) polymorphism of the GLO I gene is associated with vascular dis... | BeFree | 20185929 | Detail |
| 0.003 | Diabetes | In a multiple regression analysis with GLO1 activity as the dependent variable, ... | BeFree | 23360186 | Detail |
| <0.001 | Huntington disease | The A419C (E111A) polymorphism of the GLO I gene is associated with vascular dis... | BeFree | 20185929 | Detail |
| 0.005 | panic disorder | Association analysis of the functional Ala111Glu polymorphism of the glyoxalase ... | BeFree | 16352396 | Detail |
| 0.002 | breast carcinoma | Glyoxalase I Glu111Ala polymorphism in patients with breast cancer. | BeFree | 19452310 | Detail |
| 0.009 | Malignant neoplasm of breast | Glyoxalase I Glu111Ala polymorphism in patients with breast cancer. | BeFree | 19452310 | Detail |
| 0.009 | Malignant neoplasm of breast | Glyoxalase I Ala111Glu gene polymorphism: No association with breast cancer risk... | BeFree | 20712647 | Detail |
| 0.005 | multiple sclerosis | Glyoxalase I A111E, paraoxonase 1 Q192R and L55M polymorphisms: susceptibility f... | BeFree | 17463067 | Detail |
| 0.002 | breast carcinoma | Glyoxalase I Ala111Glu gene polymorphism: No association with breast cancer risk... | BeFree | 20712647 | Detail |
| 0.002 | breast carcinoma | NA | BeFree | Detail | |
| <0.001 | Secondary malignant neoplasm of lymph node | NA | BeFree | Detail | |
| <0.001 | colon carcinoma | NA | BeFree | Detail | |
| <0.001 | stomach carcinoma | Integrated genomic and functional analyses reveal glyoxalase I as a novel metabo... | BeFree | 24662817 | Detail |
| <0.001 | Malignant neoplasm of kidney | Polymorphisms of the receptor for advanced glycation end-products and glyoxalase... | BeFree | 25407489 | Detail |
| <0.001 | 21-hydroxylase deficiency | NA | BeFree | Detail | |
| <0.001 | Endothelial dysfunction | Glyoxalase I reduces glycative and oxidative stress and prevents age-related end... | BeFree | 24612481 | Detail |
| <0.001 | Renal ischaemia | NA | BeFree | Detail | |
| <0.001 | sarcoma | NA | BeFree | Detail | |
| <0.001 | renal carcinoma | Polymorphisms of the receptor for advanced glycation end-products and glyoxalase... | BeFree | 25407489 | Detail |
| <0.001 | Mammary Neoplasms | NA | BeFree | Detail | |
| <0.001 | Congenital vascular anomaly | Polymorphisms in the genes encoding for enzymes involved in the antioxidant syst... | BeFree | 26122242 | Detail |
| <0.001 | Cavernous Hemangioma of Brain | We found that individuals with the GLO1 A /E genotype, PON192/QR-RR genotypes an... | BeFree | 26122242 | Detail |
| <0.001 | Congenital adrenal hyperplasia due to 21 hydroxylase deficiency | NA | BeFree | Detail | |
| <0.001 | congenital adrenal hyperplasia | NA | BeFree | Detail | |
| 0.002 | Albuminuria | NA | GAD | Detail | |
| <0.001 | Alzheimer's disease | NA | BeFree | Detail | |
| 0.121 | Anxiety Disorders | It was claimed to be linked to anxiety phenotypes, but other related discordant ... | BeFree,CTD_human | 24646268 | Detail |
| <0.001 | arteriosclerosis | We here investigated whether overexpression of human GLO1 in ApoE(-/-) mice coul... | BeFree | 25139743 | Detail |
| <0.001 | atherosclerosis | We here investigated whether overexpression of human GLO1 in ApoE(-/-) mice coul... | BeFree | 25139743 | Detail |
| 0.126 | autistic disorder | The GLO1 C332 (Ala111) allele confers autism vulnerability: family-based genetic... | BeFree,CTD_human,GAD | 25201284 | Detail |
| 0.002 | Mental disorders | NA | GAD | Detail | |
| 0.009 | Malignant neoplasm of breast | NA | BeFree,GAD | Detail | |
| <0.001 | Malignant tumor of colon | NA | BeFree | Detail | |
| <0.001 | renal cell carcinoma | NA | BeFree | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Glo1 inducers are in development to sustain healthy aging and for treatment of vascular complication... | DisGeNET | Detail |
| Glo1 inducers are in development to sustain healthy aging and for treatment of vascular complication... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in huma... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The prevalence of GLO1 copy number increase in the human population appears to be approximately 2% a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here, we investigated the role of the glyoxalase system in schizophrenia by performing association a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms in the genes encoding for enzymes involved in the antioxidant systems such as glyoxala... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Gl... | DisGeNET | Detail |
| Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--im... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis... | DisGeNET | Detail |
| In a multiple regression analysis with GLO1 activity as the dependent variable, including the Ala111... | DisGeNET | Detail |
| The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis... | DisGeNET | Detail |
| In a multiple regression analysis with GLO1 activity as the dependent variable, including the Ala111... | DisGeNET | Detail |
| The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis... | DisGeNET | Detail |
| Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic diso... | DisGeNET | Detail |
| Glyoxalase I Glu111Ala polymorphism in patients with breast cancer. | DisGeNET | Detail |
| Glyoxalase I Glu111Ala polymorphism in patients with breast cancer. | DisGeNET | Detail |
| Glyoxalase I Ala111Glu gene polymorphism: No association with breast cancer risk but correlated with... | DisGeNET | Detail |
| Glyoxalase I A111E, paraoxonase 1 Q192R and L55M polymorphisms: susceptibility factors of multiple s... | DisGeNET | Detail |
| Glyoxalase I Ala111Glu gene polymorphism: No association with breast cancer risk but correlated with... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in huma... | DisGeNET | Detail |
| Polymorphisms of the receptor for advanced glycation end-products and glyoxalase I in patients with ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms of the receptor for advanced glycation end-products and glyoxalase I in patients with ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms in the genes encoding for enzymes involved in the antioxidant systems such as glyoxala... | DisGeNET | Detail |
| We found that individuals with the GLO1 A /E genotype, PON192/QR-RR genotypes and PON55/LM-MM genoty... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| It was claimed to be linked to anxiety phenotypes, but other related discordant findings have doubte... | DisGeNET | Detail |
| We here investigated whether overexpression of human GLO1 in ApoE(-/-) mice could reduce the develop... | DisGeNET | Detail |
| We here investigated whether overexpression of human GLO1 in ApoE(-/-) mice could reduce the develop... | DisGeNET | Detail |
| The GLO1 C332 (Ala111) allele confers autism vulnerability: family-based genetic association and fun... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs2736654 dbSNP
- Genome
- hg38
- Position
- chr6:38,675,925-38,703,145
- Variant Type
- snv
Genome browser