MCL1 UNDEREXPRESSION Detail (hg19) (MCL1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr1:150,535,578-150,552,214 |
| hg38 | chr1:150,563,102-150,579,738 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
| Type | Database | ID | Link |
|---|---|---|---|
| Gene | MIM | ||
| HGNC | |||
| Ensembl | |||
| NCBI | |||
| Gene Cards | |||
| OncoKB |
| Type | Database | ID | Link |
|---|---|---|---|
| Variant | TogoVar | ||
| COSMIC | |||
| MONDO |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| ABT-737 on its own was ineffective in melanoma cells unless Mcl-1 was experimentally downregulated | MMMP | Detail |
| Tunicamycin is an endoplasmic reticulum (ER) stress inducer | MMMP | Detail |
| Thapsigargin is an endoplasmic reticulum (ER) stress inducer | MMMP | Detail |
| Obatoclax is a Bcl-2 family (including Mcl-1) inhibitor that induces apoptosis through Bak and Bax a... | MMMP | Detail |
| In this model bortezomib seems to act by increasing NOXA levels and fludarabine by decreasing Mcl-1 ... | MMMP | Detail |
| Gossypol inhibits Bcl-2, Bcl-xL and Mcl-1, but siRNA experiments showed that Mcl-1 must be inhibited... | MMMP | Detail |
| ABT-737 is a small molecule inhibitor of Bcl-2, Bcl-xL and Bcl-W. RNA silencing of Mcl-1 enhances AB... | MMMP | Detail |
| Tunicamycin is an endoplasmic reticulum (ER) stress inducer | MMMP | Detail |
| Thapsigargin is an endoplasmic reticulum (ER) stress inducer | MMMP | Detail |
| Mcl-1 might inhibit melanoma cell killing by immune cells | MMMP | Detail |
| In this model bortezomib seems to act by increasing NOXA levels | MMMP | Detail |
| U0126: MEK inhibitor. Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-in... | MMMP | Detail |
| Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model | MMMP | Detail |
| ABT-737: Bcl-2, Bcl-xL and Bcl-W inhibitor (BH3 mimetic). siRNA-mediated inhibition of Mcl-1 express... | MMMP | Detail |
| Mcl-1 blocks radiation-induced apoptosis and inhibits clonogenic cell death | MMMP | Detail |
| Downregulation of Mcl-1 by antisense oligodeoxynucleotides in combination with betulinic treatment l... | MMMP | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr1:150,535,578-150,552,214
- Variant Type
- cnv
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