Annotation Detail
Information
- Associated Genes
- MCL1
- Associated Variants
- MCL1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- ABT-737 is a small molecule inhibitor of Bcl-2, Bcl-xL and Bcl-W. RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma, which is caspase-8 dependent
- MMMP State
- downregulated by
- MMMP Molecule
- Mcl-1
- MMMP Modifier
- Mcl-1 siRNA
- MMMP Relationship
- sensitivity to
- MMMP Drug
- ABT-737
- MMMP Model
- 3
- MMMP Reference
- Keuling AM, PLoS One 2009, 4:e6651
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| ABT-737 | Sensitivity | true |