Annotation Detail
Information
- Associated Genes
- MCL1
- Associated Variants
- MCL1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In this model bortezomib seems to act by increasing NOXA levels and fludarabine by decreasing Mcl-1 levels
- MMMP State
- inhibited by
- MMMP Molecule
- Mcl-1
- MMMP Modifier
- Fludarabine
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Bortezomib
- MMMP Drug Alias
- Velcade (R)
- MMMP Model
- 3
- MMMP Reference
- Qin JZ, Cancer Res 2006, 66:9636-45
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Bortezomib | Sensitivity | true |