Annotation Detail
Information
- Associated Genes
- MCL1
- Associated Variants
- MCL1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Gossypol inhibits Bcl-2, Bcl-xL and Mcl-1, but siRNA experiments showed that Mcl-1 must be inhibited to synergize with bortezomib. Mcl-1 is induced by bortezomib, which reduces its therapeutic activity.
- MMMP Drug
- Bortezomib
- MMMP Drug Alias
- Velcade (R)
- MMMP Model
- 4
- MMMP State
- inhibited by
- MMMP Molecule
- Mcl-1
- MMMP Modifier
- Gossypol
- MMMP Relationship
- sensitivity to
- MMMP Reference
- Wolter KG, Cell Death Differ 2007, 14:1605-16
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Bortezomib | Sensitivity | true |