Annotation Detail
Information
- Associated Genes
- MCL1
- Associated Variants
- MCL1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- ABT-737: Bcl-2, Bcl-xL and Bcl-W inhibitor (BH3 mimetic). siRNA-mediated inhibition of Mcl-1 expression significantly increased sensitivity to ABT-737
- MMMP State
- downregulated by
- MMMP Molecule
- Mcl-1
- MMMP Modifier
- Mcl-1 siRNA
- MMMP Relationship
- sensitivity to
- MMMP Drug
- ABT-737
- MMMP Model
- 3
- MMMP Reference
- Miller LA, J Invest Dermatol 2009, 129:964-71
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| ABT-737 | Sensitivity | true |