Annotation Detail
Information
- Associated Genes
- MCL1
- Associated Variants
- MCL1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Obatoclax is a Bcl-2 family (including Mcl-1) inhibitor that induces apoptosis through Bak and Bax activity; bortezomib is a proteasome inhibitor
- MMMP State
- inhibited by
- MMMP Molecule
- Mcl-1
- MMMP Modifier
- Obatoclax
- MMMP Modifier Alias
- GX15-070
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Bortezomib
- MMMP Drug Alias
- Velcade (R)
- MMMP Model
- 1
- MMMP Reference
- Nguyen M, Proc Natl Acad Sci USA 2007, 104:19512-7
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Bortezomib | Sensitivity | true |