PD173074

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Information
Drug Name
PD173074
Description
Entry(CIViC)
9
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
endometrial cancer FGFR2 p.Asn550Lys (p.N550K)
( ENST00000369061.8, ENST00000369060.8, ENST00000369059.5, ENST00000478859.5, ENST00000457416.7, ENST00000346997.6, ENST00000351936.11, ENST00000356226.8, ENST00000357555.9, ENST00000358487.10, ENST00000360144.7, ENST00000369056.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1, ENST00000684153.1 ) FGFR2 p.Asn550Lys (p.N550K)
( ENST00000346997.6, ENST00000351936.11, ENST00000369061.8, ENST00000356226.8, ENST00000357555.9, ENST00000684153.1, ENST00000358487.10, ENST00000360144.7, ENST00000369056.5, ENST00000369059.5, ENST00000369060.8, ENST00000457416.7, ENST00000478859.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1 ) 		D Predictive Supports Sensitivity/Response Somatic 3 18757403 Detail
bladder carcinoma FGFR3 FGFR3-BAIAP2L1 D Predictive Supports Sensitivity/Response Somatic 3 23558953 Detail
cholangiocarcinoma FGFR2 FGFR2-BICC1 D Predictive Supports Sensitivity/Response Somatic 3 24122810 Detail
cholangiocarcinoma FGFR2 FGFR2-AHCYL1 D Predictive Supports Sensitivity/Response Somatic 3 24122810 Detail
sarcoma FGFR1 EXPRESSION FGFR1 EXPRESSION D Predictive Supports Sensitivity/Response Somatic 3 27535980 Detail
lung squamous cell carcinoma FGFR1 AMPLIFICATION
( ENST00000425967.8 ) FGFR1 AMPLIFICATION
( ENST00000425967.8 ) 		D Predictive Supports Sensitivity/Response Somatic 5 21160078 Detail
lung non-small cell carcinoma FGFR1 AMPLIFICATION
( ENST00000425967.8 ) FGFR1 AMPLIFICATION
( ENST00000425967.8 ) 		D Predictive Supports Sensitivity/Response Somatic 4 21666749 Detail
bladder carcinoma FGFR1 EXPRESSION FGFR1 EXPRESSION D Predictive Supports Sensitivity/Response N/A 2 21119661 Detail
bladder carcinoma FGFR3 EXPRESSION FGFR3 EXPRESSION D Predictive Supports Sensitivity/Response N/A 3 21119661 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
The endometrial cancer cell lines, AN3CA and MFE29... FGFR2 FGFR2 p.Asn550Lys (p.N550K)
( ENST00000369061.8, ENST00000369060.8, ENST00000369059.5, ENST00000478859.5, ENST00000457416.7, ENST00000346997.6, ENST00000351936.11, ENST00000356226.8, ENST00000357555.9, ENST00000358487.10, ENST00000360144.7, ENST00000369056.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1, ENST00000684153.1 ) FGFR2 p.Asn550Lys (p.N550K)
( ENST00000346997.6, ENST00000351936.11, ENST00000369061.8, ENST00000356226.8, ENST00000357555.9, ENST00000684153.1, ENST00000358487.10, ENST00000360144.7, ENST00000369056.5, ENST00000369059.5, ENST00000369060.8, ENST00000457416.7, ENST00000478859.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1 ) 		Sensitivity true CIViC Evidence detail
Following identification of this fusion in a patie... FGFR3 FGFR3 FGFR3-BAIAP2L1 Sensitivity true CIViC Evidence detail
Expression of the FGFR2-BICC1 fusion kinase in NIH... FGFR2 FGFR2 FGFR2-BICC1 Sensitivity true CIViC Evidence detail
Expression of the FGFR2-AHCYL1 fusion kinase in NI... FGFR2 FGFR2 FGFR2-AHCYL1 Sensitivity true CIViC Evidence detail
Targeting of FGFR1 by RNA interference and small-m... FGFR1 FGFR1 EXPRESSION FGFR1 EXPRESSION Sensitivity true CIViC Evidence detail
Preclinical (in-vitro, in-vivo) evidence suggests ... FGFR1 FGFR1 AMPLIFICATION
( ENST00000425967.8 ) FGFR1 AMPLIFICATION
( ENST00000425967.8 ) 		Sensitivity true CIViC Evidence detail
Preclinical study showing FGFR1 amplification in N... FGFR1 FGFR1 AMPLIFICATION
( ENST00000425967.8 ) FGFR1 AMPLIFICATION
( ENST00000425967.8 ) 		Sensitivity true CIViC Evidence detail
One urothelial cell line (JMSU1) with high express... FGFR1 FGFR1 EXPRESSION FGFR1 EXPRESSION Sensitivity true CIViC Evidence detail
The effects of FGFR inhibitors (PD173074, TKI-258 ... FGFR3 FGFR3 EXPRESSION FGFR3 EXPRESSION Sensitivity true CIViC Evidence detail