Annotation Detail
Information
- Associated Genes
- FGFR3
- Associated Variants
-
FGFR3 EXPRESSION
FGFR3 EXPRESSION - Associated Disease
- bladder carcinoma
- Source Database
- CIViC Evidence
- Description
- The effects of FGFR inhibitors (PD173074, TKI-258 and SU5402) in bladder carcinoma cell lines were related to FGFR3 (and/or FGFR1) expression.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/803
- Gene URL
- https://civic.genome.wustl.edu/links/genes/23
- Variant URL
- https://civic.genome.wustl.edu/links/variants/325
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Bladder Carcinoma
- Evidence Direction
- Supports
- Drug
- Dovitinib,Tyrosine Kinase Inhibitor SU5402,PD173074
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21119661
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dovitinib | Sensitivity | true |
| PD173074 | Sensitivity | true |
| Tyrosine Kinase Inhibitor SU5402 | Sensitivity | true |