Annotation Detail

Information
Associated Genes
FGFR1
Associated Variants
FGFR1 AMPLIFICATION ( ENST00000425967.8 )
FGFR1 AMPLIFICATION ( ENST00000425967.8 )
Associated Disease
lung squamous cell carcinoma
Source Database
CIViC Evidence
Description
Preclinical (in-vitro, in-vivo) evidence suggests predictive value of FGFR1 amplification for treatment with FGFR1-inhibitors. 4 of 83 cell lines exhibited FGFR1 amplification, and 3 of these were highly sensitive to PD173074. This sensitivity was confirmed in a mouse xenograft. Clinical trials are currently ongoing.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/680
Gene URL
https://civic.genome.wustl.edu/links/genes/1885
Variant URL
https://civic.genome.wustl.edu/links/variants/267
Rating
5
Evidence Type
Predictive
Disease
Lung Squamous Cell Carcinoma
Evidence Direction
Supports
Drug
PD173074
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
21160078
Drugs
Drug NameSensitivitySupported
PD173074Sensitivitytrue