Annotation Detail
Information
- Associated Genes
- FGFR2
- Associated Variants
- FGFR2 FGFR2-AHCYL1
- Associated Disease
- cholangiocarcinoma
- Source Database
- CIViC Evidence
- Description
- Expression of the FGFR2-AHCYL1 fusion kinase in NIH3T3 cells demonstrated transforming ability that was effectively suppressed with the fibroblast growth factor receptor (FGFR) kinase inhibitors BGJ398 and PD173074.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1853
- Gene URL
- https://civic.genome.wustl.edu/links/genes/22
- Variant URL
- https://civic.genome.wustl.edu/links/variants/783
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Cholangiocarcinoma
- Evidence Direction
- Supports
- Drug
- PD173074,Infigratinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24122810
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Infigratinib | Sensitivity | true |
| PD173074 | Sensitivity | true |