Annotation Detail
Information
- Associated Genes
- FGFR1
- Associated Variants
-
FGFR1 AMPLIFICATION
(
ENST00000425967.8 )
FGFR1 AMPLIFICATION ( ENST00000425967.8 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Preclinical study showing FGFR1 amplification in NSCLC and efficacy of FGFR-1 inhibition in one amplified cell line.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/686
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1885
- Variant URL
- https://civic.genome.wustl.edu/links/variants/267
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- PD173074
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21666749
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| PD173074 | Sensitivity | true |