Annotation Detail
Information
- Associated Genes
- FGFR1
- Associated Variants
-
FGFR1 EXPRESSION
FGFR1 EXPRESSION - Associated Disease
- sarcoma
- Source Database
- CIViC Evidence
- Description
- Targeting of FGFR1 by RNA interference and small-molecule inhibitors (PD173074, AZD4547, BGJ398) revealed that the requirement for FGFR1 signaling in STS cells is dictated by FGFR1 expression levels, and identified the MAPK-ERK1/2 axis as critical FGFR1 effector pathway.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2915
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1885
- Variant URL
- https://civic.genome.wustl.edu/links/variants/268
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Sarcoma
- Evidence Direction
- Supports
- Drug
- Infigratinib,FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074,FGFR Inhibitor AZD4547
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 27535980
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| FGF/VEGF Receptor Tyrosine Kinase Inhibitor | Sensitivity | true |
| FGFR Inhibitor AZD4547 | Sensitivity | true |
| Infigratinib | Sensitivity | true |
| PD173074 | Sensitivity | true |