chr6:154039662:A>G Detail (hg38) (OPRM1)

Information

Genome

Assembly Position
hg19 chr6:154,360,797-154,360,797 View the variant detail on this assembly version.
hg38 chr6:154,039,662-154,039,662

HGVS

Type Transcript Protein
RefSeq NM_001008505.2:c.118A>G NP_001008505.2:p.Asn40Asp
NM_000914.4:c.118A>G NP_000905.3:p.Asn40Asp
NM_001008503.2:c.118A>G NP_001008503.2:p.Asn40Asp
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:0.420
ToMMo:0.447
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:0.382

Prediction

ClinVar

Clinical Significance Uncertain significance; drug response
Review star
Show details
Links
Type Database ID Link
Gene MIM 600018 OMIM
HGNC 8156 HGNC
Ensembl ENSG00000112038 Ensembl
NCBI NCBI
Gene Cards Gene Cards
OncoKB OncoKB
Type Database ID Link
Variant TogoVar tgv27548008 TogoVar
COSMIC
MONDO
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
Uncertain significance 2009-06-30 no assertion criteria provided Opioid dependence, susceptibility to, 1 germline Detail
drug response 2018-04-28 no assertion criteria provided somatic Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.006 Pain Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 ge... BeFree 25576257 Detail
0.102 Pain Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 ge... BeFree 25576257 Detail
0.001 Chronic pain Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute ... BeFree 23803057 Detail
0.001 Cancer pain Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirem... BeFree 23803057 Detail
0.236 Pain Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 ge... BeFree 25576257 Detail
<0.001 Chronic pain Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute ... BeFree 23803057 Detail
0.133 nicotine dependence The purpose of this study was to analyse the association of smoking status and s... BeFree 22046326 Detail
<0.001 nicotine dependence The purpose of this study was to analyse the association of smoking status and s... BeFree 22046326 Detail
0.020 nicotine dependence The purpose of this study was to analyse the association of smoking status and s... BeFree 22046326 Detail
0.003 nicotine dependence The purpose of this study was to analyse the association of smoking status and s... BeFree 22046326 Detail
0.002 nicotine dependence The purpose of this study was to analyse the association of smoking status and s... BeFree 22046326 Detail
0.001 nicotine dependence The purpose of this study was to analyse the association of smoking status and s... BeFree 22046326 Detail
0.159 Alcoholic Intoxication, Chronic Variation at a single nucleotide polymorphism in the μ-opioid receptor gene (OPR... BeFree 23032071 Detail
<0.001 Flushing Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.011 Flushing Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
<0.001 Primary biliary cirrhosis A study of the mu opioid receptor gene polymorphism A118G in patients with prima... BeFree 18709298 Detail
0.159 Alcoholic Intoxication, Chronic Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for ... BeFree 22909206 Detail
<0.001 Dysphoric mood Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.007 Absence of pain sensation Association of mu-opioid receptor gene polymorphism (A118G) with variations in m... BeFree 16879459 Detail
0.008 Postoperative Nausea and Vomiting Study of the OPRM1 A118G genetic polymorphism associated with postoperative naus... BeFree 21150856 Detail
0.007 Absence of pain sensation Modeling the influence of the A118G polymorphism in the OPRM1 gene and of noxiou... BeFree 23503369 Detail
<0.001 Headache The human μ-opioid receptor gene polymorphism (A118G) is associated with head pa... BeFree 22752568 Detail
0.159 Alcoholic Intoxication, Chronic These results suggest that, while the risk of alcoholism in Korean men is predom... BeFree 20077761 Detail
0.102 Pain The A118G polymorphism of mu-opioid receptor may be closely associated with DFU ... BeFree 19303332 Detail
0.014 substance dependence A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to ... BeFree 23543091 Detail
0.347 Alcoholic Intoxication, Chronic Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.007 Absence of pain sensation The present study aimed to investigate the effect of cytochrome P450 3A4 (CYP3A4... BeFree 23313934 Detail
0.120 Dyskinetic syndrome Carrying the G-allele of the A118G single nucleotide coding region polymorphism ... BeFree 16435402 Detail
0.159 Alcoholic Intoxication, Chronic Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
<0.001 migraine with aura The human μ-opioid receptor gene polymorphism (A118G) is associated with head pa... BeFree 22752568 Detail
0.012 Heroin Abuse Mu opioid receptors are critical for heroin dependence, and A118G SNP of the mu ... BeFree 16682632 Detail
<0.001 Dysphoric mood Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.002 Malignant neoplasm of breast μ-Opioid receptor gene A118G polymorphism predicts survival in patients with bre... BeFree 22433205 Detail
0.159 Alcoholic Intoxication, Chronic The A118G (rs 1799971) polymorphism in the mu-opioid receptor gene (OPRM1) has b... BeFree 23254216 Detail
0.001 Anxiety Disorders Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.157 Alcoholic Intoxication, Chronic Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.159 Alcoholic Intoxication, Chronic OPRM1 A118G genotype fails to predict the effectiveness of naltrexone treatment ... BeFree 21946895 Detail
0.007 Absence of pain sensation The presence of the A118G single nucleotide polymorphism (SNP) in the OPRM1 gene... BeFree 25570943 Detail
0.007 Opiate Addiction In addition, it is critical that other OPRM1 variants, including all haplotype-t... BeFree 17416470 Detail
<0.001 Aortic Aneurysm, Thoracic Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G595... BeFree 19018716 Detail
0.159 Alcoholic Intoxication, Chronic Genetic analyses of the level of response to alcohol, particularly of the functi... BeFree 24220019 Detail
0.471 Alcoholic Intoxication, Chronic These results suggest that, while the risk of alcoholism in Korean men is predom... BeFree 20077761 Detail
<0.001 Anxiety Disorders Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.004 drug dependence A significant association was observed between A118G polymorphism in μ opioid re... BeFree 22744787 Detail
0.004 drug dependence A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor ... BeFree 20074870 Detail
0.159 Alcoholic Intoxication, Chronic Two hundred and sixty-five nontreatment-seeking individuals with alcohol depende... BeFree 22551036 Detail
0.014 substance dependence Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene w... BeFree 16387451 Detail
0.014 substance dependence A significant association was observed between A118G polymorphism in μ opioid re... BeFree 22744787 Detail
0.007 Absence of pain sensation A118G single nucleotide polymorphism of human mu-opioid receptor gene influences... BeFree 18719451 Detail
0.159 Alcoholic Intoxication, Chronic A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to ... BeFree 23543091 Detail
0.121 idiopathic generalized epilepsy Our results provide no support for association of A118G with either IAE or IGE a... BeFree 17054695 Detail
0.159 Alcoholic Intoxication, Chronic The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on ... BeFree 21895723 Detail
<0.001 ischemic pain Responses to thermal, mechanical, and ischemic pain were assessed in all subject... BeFree 15772909 Detail
0.102 Pain Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation,... BeFree 25308352 Detail
0.159 Alcoholic Intoxication, Chronic The Asn40Asp variant (A118G) of the μ opioid receptor (OPRM1) gene is thought to... BeFree 22397905 Detail
0.014 substance dependence Genetic variants of OPRM1 have been implicated in predisposition to drug addicti... BeFree 16046395 Detail
0.004 drug dependence A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPR... BeFree 19528658 Detail
<0.001 Hernia Subjective health complaints in patients with lumbar radicular pain and disc her... BeFree 24884878 Detail
<0.001 cholestasis The possibility of protection from pruritus associated with A118G supports the s... BeFree 18709298 Detail
0.159 Alcoholic Intoxication, Chronic The functional polymorphism (A118G) of the mu-opioid receptor gene (OPRM1) is th... BeFree 15252283 Detail
<0.001 Absence of pain sensation The present study aimed to investigate the effect of cytochrome P450 3A4 (CYP3A4... BeFree 23313934 Detail
<0.001 Nausea and vomiting This study aimed to investigate whether the genetic polymorphism of OPRM1 A118G ... BeFree 21150856 Detail
0.007 Opiate Addiction OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysi... BeFree 23651028 Detail
0.007 Absence of pain sensation To clarify the functional mechanisms linking the OPRM1 A118G SNP to addiction an... BeFree 19528658 Detail
0.004 drug dependence A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to ... BeFree 23543091 Detail
0.007 Absence of pain sensation To further understand the human implications of genetic variation within the opi... BeFree 25308352 Detail
0.014 substance dependence Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G poly... BeFree 11424981 Detail
0.004 drug dependence Genetic variants of OPRM1 have been implicated in predisposition to drug addicti... BeFree 16046395 Detail
0.007 Absence of pain sensation Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during l... BeFree 23909491 Detail
0.159 Alcoholic Intoxication, Chronic Association of mu-opioid receptor gene polymorphism A118G with alcohol dependenc... BeFree 16679777 Detail
0.007 Absence of pain sensation Study of the OPRM1 A118G genetic polymorphism associated with postoperative naus... BeFree 21150856 Detail
<0.001 Acute onset pain The mu opioid receptor A118G gene polymorphism moderates effects of trait anger-... BeFree 18579306 Detail
<0.001 Substance Use Disorders Compared to controls, ADHD patients (with and without SUDs) showed significantly... BeFree 22841130 Detail
0.007 Absence of pain sensation The A118G single-nucleotide polymorphism of human μ-opioid receptor gene and use... BeFree 22527985 Detail
0.001 Chronic pain A genetic association study of the functional A118G polymorphism of the human mu... BeFree 17000822 Detail
<0.001 Migraine Disorders These findings suggest that A118G genotypes of the OPRM1 gene may influence migr... BeFree 22752568 Detail
0.006 fibromyalgia Assessment of opioid receptor μ1 gene A118G polymorphism and its association wit... BeFree 24671502 Detail
0.159 Alcoholic Intoxication, Chronic Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphis... BeFree 22071118 Detail
0.102 Pain The results indicate that among the genetic SNPs we studied which include those ... BeFree 25794200 Detail
0.014 substance dependence A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPR... BeFree 19528658 Detail
0.347 Alcoholic Intoxication, Chronic These results suggest that, while the risk of alcoholism in Korean men is predom... BeFree 20077761 Detail
0.008 Pruritus The purpose of this study was to investigate the association between the severit... BeFree 21039348 Detail
<0.001 Prolapsed lumbar disc Pain intensity the first year after lumbar disc herniation is associated with th... BeFree 22815498 Detail
0.021 Pain, Postoperative The OPRM1 A118G polymorphism may help predict individuals' response to epidural ... BeFree 23909491 Detail
0.159 Alcoholic Intoxication, Chronic Our results suggest main effect of education background, OPRM1 A118G, and DRD2 -... BeFree 19764934 Detail
0.006 schizophrenia A118G polymorphism of OPRM1 gene is associated with schizophrenia. BeFree 20112002 Detail
0.102 Pain Assessment of opioid receptor μ1 gene A118G polymorphism and its association wit... BeFree 24671502 Detail
0.001 heavy drinking Secondary analysis of clinical trial data suggests that a functional polymorphis... BeFree 25760804 Detail
0.134 heroin dependence Mu opioid receptors are critical for heroin dependence, and A118G SNP of the mu ... BeFree 16682632 Detail
0.007 Absence of pain sensation The purpose of this study was to investigate the association between the severit... BeFree 21039348 Detail
0.001 alcohol use disorder Adolescents (n = 187; mean age = 15.4 years; 47.6% female) were genotyped for A1... BeFree 19860800 Detail
0.001 heavy drinking The sample consisted of 84 heavy drinking young men without a g-allele in the A1... BeFree 19016889 Detail
0.159 Alcoholic Intoxication, Chronic In the present investigation we hypothesized the A118G (Asn40Asp) polymorphism o... BeFree 11424981 Detail
0.102 Pain The purpose of this work is to evaluate the influence of the SNP A118G in OPRM1 ... BeFree 25570943 Detail
<0.001 Substance Use Disorders Compared to controls, ADHD patients (with and without SUDs) showed significantly... BeFree 22841130 Detail
0.159 Alcoholic Intoxication, Chronic Recent clinical and laboratory studies have shown that the effects of naltrexone... BeFree 21900886 Detail
0.014 substance dependence A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor ... BeFree 20074870 Detail
0.008 Pruritus A study of the mu opioid receptor gene polymorphism A118G in patients with prima... BeFree 18709298 Detail
0.017 Anxiety Disorders Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.204 Alcoholic Intoxication, Chronic Our results suggest main effect of education background, OPRM1 A118G, and DRD2 -... BeFree 19764934 Detail
0.021 Pain, Postoperative No statistically significant association was observed between the presence of A1... BeFree 17000822 Detail
0.159 Alcoholic Intoxication, Chronic The best-studied functional genetic variant relevant to alcoholism treatment is ... BeFree 22587755 Detail
0.215 Alcoholic Intoxication, Chronic Genetic analyses of the level of response to alcohol, particularly of the functi... BeFree 24220019 Detail
0.001 alcohol use disorder The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and a... BeFree 23729673 Detail
0.159 Alcoholic Intoxication, Chronic These results do not support association of the OPRM1 Asn40Asp polymorphism with... BeFree 17374034 Detail
0.035 Alcoholic Intoxication, Chronic Two hundred and sixty-five nontreatment-seeking individuals with alcohol depende... BeFree 22551036 Detail
0.001 heavy drinking Estimates of effect for return to heavy drinking suggest it is possible that pat... BeFree 25410894 Detail
0.159 Alcoholic Intoxication, Chronic μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnis... BeFree 23729673 Detail
0.002 breast carcinoma μ-Opioid receptor gene A118G polymorphism predicts survival in patients with bre... BeFree 22433205 Detail
<0.001 Pituitary Diseases Mu-opioid receptor A118G polymorphism in healthy volunteers affects hypothalamic... BeFree 21507151 Detail
0.007 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.014 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
<0.001 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.002 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.006 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.003 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
Annotation

Annotations

DescrptionSourceLinks
NM_000914.5(OPRM1):c.118A>G (p.Asn40Asp) AND Opioid dependence, susceptibility to, 1 ClinVar Detail
NM_000914.5(OPRM1):c.118A>G (p.Asn40Asp) AND Tramadol response ClinVar Detail
Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transport... DisGeNET Detail
Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transport... DisGeNET Detail
Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual ... DisGeNET Detail
Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirements in Chinese pati... DisGeNET Detail
Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transport... DisGeNET Detail
Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual ... DisGeNET Detail
The purpose of this study was to analyse the association of smoking status and smoking-related pheno... DisGeNET Detail
The purpose of this study was to analyse the association of smoking status and smoking-related pheno... DisGeNET Detail
The purpose of this study was to analyse the association of smoking status and smoking-related pheno... DisGeNET Detail
The purpose of this study was to analyse the association of smoking status and smoking-related pheno... DisGeNET Detail
The purpose of this study was to analyse the association of smoking status and smoking-related pheno... DisGeNET Detail
The purpose of this study was to analyse the association of smoking status and smoking-related pheno... DisGeNET Detail
Variation at a single nucleotide polymorphism in the μ-opioid receptor gene (OPRM1), A118G (Asn40Asp... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
A study of the mu opioid receptor gene polymorphism A118G in patients with primary biliary cirrhosis... DisGeNET Detail
Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the c... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption ... DisGeNET Detail
Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting indu... DisGeNET Detail
Modeling the influence of the A118G polymorphism in the OPRM1 gene and of noxious stimulation on the... DisGeNET Detail
The human μ-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a cli... DisGeNET Detail
These results suggest that, while the risk of alcoholism in Korean men is predominantly affected by ... DisGeNET Detail
The A118G polymorphism of mu-opioid receptor may be closely associated with DFU pain in 34 out of 50... DisGeNET Detail
A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to an amino acid change... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
The present study aimed to investigate the effect of cytochrome P450 3A4 (CYP3A4)*18B polymorphisms ... DisGeNET Detail
Carrying the G-allele of the A118G single nucleotide coding region polymorphism of the mu opioid rec... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
The human μ-opioid receptor gene polymorphism (A118G) is associated with head pain severity in a cli... DisGeNET Detail
Mu opioid receptors are critical for heroin dependence, and A118G SNP of the mu opioid receptor gene... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer. DisGeNET Detail
The A118G (rs 1799971) polymorphism in the mu-opioid receptor gene (OPRM1) has been reported to be a... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
OPRM1 A118G genotype fails to predict the effectiveness of naltrexone treatment for alcohol dependen... DisGeNET Detail
The presence of the A118G single nucleotide polymorphism (SNP) in the OPRM1 gene affects the require... DisGeNET Detail
In addition, it is critical that other OPRM1 variants, including all haplotype-tagging and amino-aci... DisGeNET Detail
Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and ... DisGeNET Detail
Genetic analyses of the level of response to alcohol, particularly of the functional OPRM1 A118G pol... DisGeNET Detail
These results suggest that, while the risk of alcoholism in Korean men is predominantly affected by ... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
A significant association was observed between A118G polymorphism in μ opioid receptor gene and drug... DisGeNET Detail
A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor gene can affect opio... DisGeNET Detail
Two hundred and sixty-five nontreatment-seeking individuals with alcohol dependence were genotyped a... DisGeNET Detail
Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance depend... DisGeNET Detail
A significant association was observed between A118G polymorphism in μ opioid receptor gene and drug... DisGeNET Detail
A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and... DisGeNET Detail
A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to an amino acid change... DisGeNET Detail
Our results provide no support for association of A118G with either IAE or IGE and also exclude asso... DisGeNET Detail
The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology ... DisGeNET Detail
Responses to thermal, mechanical, and ischemic pain were assessed in all subjects, and genotyping of... DisGeNET Detail
Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and... DisGeNET Detail
The Asn40Asp variant (A118G) of the μ opioid receptor (OPRM1) gene is thought to contribute to the d... DisGeNET Detail
Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular th... DisGeNET Detail
A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been w... DisGeNET Detail
Subjective health complaints in patients with lumbar radicular pain and disc herniation are associat... DisGeNET Detail
The possibility of protection from pruritus associated with A118G supports the study of genetic poly... DisGeNET Detail
The functional polymorphism (A118G) of the mu-opioid receptor gene (OPRM1) is thought to have clinic... DisGeNET Detail
The present study aimed to investigate the effect of cytochrome P450 3A4 (CYP3A4)*18B polymorphisms ... DisGeNET Detail
This study aimed to investigate whether the genetic polymorphism of OPRM1 A118G contributed to the v... DisGeNET Detail
OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis. DisGeNET Detail
To clarify the functional mechanisms linking the OPRM1 A118G SNP to addiction and analgesia phenotyp... DisGeNET Detail
A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to an amino acid change... DisGeNET Detail
To further understand the human implications of genetic variation within the opioid system in pain a... DisGeNET Detail
Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substan... DisGeNET Detail
Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular th... DisGeNET Detail
Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysi... DisGeNET Detail
Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese popu... DisGeNET Detail
Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting indu... DisGeNET Detail
The mu opioid receptor A118G gene polymorphism moderates effects of trait anger-out on acute pain se... DisGeNET Detail
Compared to controls, ADHD patients (with and without SUDs) showed significantly increased frequency... DisGeNET Detail
The A118G single-nucleotide polymorphism of human μ-opioid receptor gene and use of labor analgesia. DisGeNET Detail
A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gen... DisGeNET Detail
These findings suggest that A118G genotypes of the OPRM1 gene may influence migraine-associated head... DisGeNET Detail
Assessment of opioid receptor μ1 gene A118G polymorphism and its association with pain intensity in ... DisGeNET Detail
Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol depend... DisGeNET Detail
The results indicate that among the genetic SNPs we studied which include those affecting analgesic ... DisGeNET Detail
A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been w... DisGeNET Detail
These results suggest that, while the risk of alcoholism in Korean men is predominantly affected by ... DisGeNET Detail
The purpose of this study was to investigate the association between the severity of central type pr... DisGeNET Detail
Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism... DisGeNET Detail
The OPRM1 A118G polymorphism may help predict individuals' response to epidural labor analgesia and ... DisGeNET Detail
Our results suggest main effect of education background, OPRM1 A118G, and DRD2 -141C Ins/Del as well... DisGeNET Detail
A118G polymorphism of OPRM1 gene is associated with schizophrenia. DisGeNET Detail
Assessment of opioid receptor μ1 gene A118G polymorphism and its association with pain intensity in ... DisGeNET Detail
Secondary analysis of clinical trial data suggests that a functional polymorphism (rs1799971, Asn40A... DisGeNET Detail
Mu opioid receptors are critical for heroin dependence, and A118G SNP of the mu opioid receptor gene... DisGeNET Detail
The purpose of this study was to investigate the association between the severity of central type pr... DisGeNET Detail
Adolescents (n = 187; mean age = 15.4 years; 47.6% female) were genotyped for A118G (rs1799971), a s... DisGeNET Detail
The sample consisted of 84 heavy drinking young men without a g-allele in the A118G (or A355G) singl... DisGeNET Detail
In the present investigation we hypothesized the A118G (Asn40Asp) polymorphism of the mu-opioid rece... DisGeNET Detail
The purpose of this work is to evaluate the influence of the SNP A118G in OPRM1 on EEG measures for ... DisGeNET Detail
Compared to controls, ADHD patients (with and without SUDs) showed significantly increased frequency... DisGeNET Detail
Recent clinical and laboratory studies have shown that the effects of naltrexone for alcoholism may ... DisGeNET Detail
A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor gene can affect opio... DisGeNET Detail
A study of the mu opioid receptor gene polymorphism A118G in patients with primary biliary cirrhosis... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Our results suggest main effect of education background, OPRM1 A118G, and DRD2 -141C Ins/Del as well... DisGeNET Detail
No statistically significant association was observed between the presence of A118G MOR polymorphism... DisGeNET Detail
The best-studied functional genetic variant relevant to alcoholism treatment is rs1799971, a single-... DisGeNET Detail
Genetic analyses of the level of response to alcohol, particularly of the functional OPRM1 A118G pol... DisGeNET Detail
The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders... DisGeNET Detail
These results do not support association of the OPRM1 Asn40Asp polymorphism with NTX treatment respo... DisGeNET Detail
Two hundred and sixty-five nontreatment-seeking individuals with alcohol dependence were genotyped a... DisGeNET Detail
Estimates of effect for return to heavy drinking suggest it is possible that patients with at least ... DisGeNET Detail
μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with a... DisGeNET Detail
μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer. DisGeNET Detail
Mu-opioid receptor A118G polymorphism in healthy volunteers affects hypothalamic-pituitary-adrenal a... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs1799971 dbSNP
Genome
hg38
Position
chr6:154,039,662-154,039,662
Variant Type
snv
Reference Allele
A
Alternative Allele
G
Filtering Status (HGVD)
PASS
# of samples (HGVD)
1207
Mean of sample read depth (HGVD)
175.72
Standard deviation of sample read depth (HGVD)
82.02
Number of reference allele (HGVD)
1401
Number of alternative allele (HGVD)
1013
Allele Frequency (HGVD)
0.41963545981772993
Gene Symbol (HGVD)
OPRM1
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs1799971
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.447
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
7492
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16760
East Asian Chromosome Counts (ExAC)
8590
East Asian Allele Counts (ExAC)
3278
East Asian Heterozygous Counts (ExAC)
2004
East Asian Homozygous Counts (ExAC)
637
East Asian Allele Frequency (ExAC)
0.38160651920838184
Chromosome Counts in All Race (ExAC)
120298
Allele Counts in All Race (ExAC)
22327
Heterozygous Counts in All Race (ExAC)
16551
Homozygous Counts in All Race (ExAC)
2888
Allele Frequency in All Race (ExAC)
0.18559743304128082
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