Annotation Detail
Information
- Associated Genes
- OPRM1
- Associated Variants
-
OPRM1 p.Asn133Asp (p.N133D)
(
ENST00000229768.9,
ENST00000330432.12,
ENST00000337049.8,
ENST00000360422.8,
ENST00000414028.6,
ENST00000419506.6,
ENST00000428397.6,
ENST00000434900.6,
ENST00000435918.6,
ENST00000452687.6,
ENST00000518759.5,
ENST00000520708.5,
ENST00000524163.5 )
OPRM1 p.Asn133Asp (p.N133D) ( ENST00000229768.9, ENST00000330432.12, ENST00000337049.8, ENST00000360422.8, ENST00000414028.6, ENST00000419506.6, ENST00000428397.6, ENST00000434900.6, ENST00000435918.6, ENST00000452687.6, ENST00000518759.5, ENST00000520708.5, ENST00000524163.5 ) - Associated Disease
- substance dependence
- Source Database
- DisGeNET
- Description
- Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular the single nucleotide polymorphism A118G, leading to an N40D substitution, with an allele frequency of 10-32%, and uncertain functions.
- Pubmed
- 16046395
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.014158584609894
- Year of publication
- 2005
Drugs