EGFR OVEREXPRESSION Detail (hg19) (EGFR)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr7:55,086,794-55,279,321 |
| hg38 | chr7:55,019,101-55,211,628 View the variant detail on this assembly version. |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| brain glioblastoma multiforme | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 14583498 | Detail | |
| head and neck squamous cell carcinoma | Cetuximab | B |
Predictive
|
Does Not Support
|
Sensitivity/Response |
N/A
|
4 | 23265711 | Detail |
| lung non-small cell carcinoma | Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 22056021 | Detail |
| lung non-small cell carcinoma | Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 26439803 | Detail |
| head and neck squamous cell carcinoma | B |
Prognostic
|
Supports
|
Poor Outcome |
N/A
|
3 | 9625170 | Detail | |
| esophagus squamous cell carcinoma | Nimotuzumab | B |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 3 | 26459251 | Detail |
| esophagus squamous cell carcinoma | B |
Prognostic
|
Supports
|
Poor Outcome |
N/A
|
3 | 26459251 | Detail | |
| lung non-small cell carcinoma | Gefitinib | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 16707605 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| In patients with glioblastoma multiforme, those with overespression of wild-type EGFR had shorter ov... | CIViC Evidence | Detail |
| EGFR expression level was not predicitive of response to cetuximab-containing first line regimens in... | CIViC Evidence | Detail |
| EGFR overexpression was correlated with longer overall survival in patients with advanced NSCLC trea... | CIViC Evidence | Detail |
| In this prospective study in 37 patients of whom 34 were treated with different EGFR inhibitors (gef... | CIViC Evidence | Detail |
| Primary tumors of 91 patients with head and neck squamous cell carcinoma were analyzed for expressio... | CIViC Evidence | Detail |
| 55 tumor samples were analyzed for EGFR expression using IHC. The objective response rate to anti-EG... | CIViC Evidence | Detail |
| 55 tumor samples were analyzed for EGFR expression using IHC. PFS and OS was shorter for the EGFR hi... | CIViC Evidence | Detail |
| 82 patients treated with gefitinib were retrospectively analyzed for EGFR mRNA expression (rt-PCR in... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- EGFR
- Genome
- hg19
- Position
- chr7:55,086,794-55,279,321
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- OVEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000275493.2
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/193
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