Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR OVEREXPRESSION
(
ENST00000275493.7 )
EGFR OVEREXPRESSION ( ENST00000275493.7 ) - Associated Disease
- head and neck squamous cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Primary tumors of 91 patients with head and neck squamous cell carcinoma were analyzed for expression of EGFR and TGF-alpha using IHC. Expression of EGFR or TGF-alpha were associated with reduced disease-free and cause-specific survival.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/782
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/193
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Head And Neck Squamous Cell Carcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 9625170
Drugs