Annotation Detail

Information
Associated Genes
EGFR
Associated Variants
EGFR OVEREXPRESSION ( ENST00000275493.7 )
EGFR OVEREXPRESSION ( ENST00000275493.7 )
Associated Disease
esophagus squamous cell carcinoma
Source Database
CIViC Evidence
Description
55 tumor samples were analyzed for EGFR expression using IHC. The objective response rate to anti-EGFR antibody nimotuzumab did not differ significantly between EGFR high- (18 pts) and EGFR low to moderate groups (37 pts).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/783
Gene URL
https://civic.genome.wustl.edu/links/genes/19
Variant URL
https://civic.genome.wustl.edu/links/variants/193
Rating
3
Evidence Type
Predictive
Disease
Esophagus Squamous Cell Carcinoma
Evidence Direction
Does Not Support
Drug
Nimotuzumab
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
26459251
Drugs
Drug NameSensitivitySupported
NimotuzumabSensitivityfalse