Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR OVEREXPRESSION
(
ENST00000275493.7 )
EGFR OVEREXPRESSION ( ENST00000275493.7 ) - Associated Disease
- esophagus squamous cell carcinoma
- Source Database
- CIViC Evidence
- Description
- 55 tumor samples were analyzed for EGFR expression using IHC. PFS and OS was shorter for the EGFR high expressing group (18 pts) than for the low to moderate expression group (37 pts). PFS: 5.8 ± 0.5 vs. 11.0 ± 2.8 months, P = 0.007; OS: 9.7 ± 0.5 vs. 21.5 ± 1.5 months, P = 0.03.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/784
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/193
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Esophagus Squamous Cell Carcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 26459251
Drugs