Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR OVEREXPRESSION
(
ENST00000275493.7 )
EGFR OVEREXPRESSION ( ENST00000275493.7 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In this prospective study in 37 patients of whom 34 were treated with different EGFR inhibitors (gefitinib, erlotinib, afatinib), EGFR mutations and a higher relative expression of EGFR in comparison to MET expression were correlated with longer PFS.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/737
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/193
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26439803
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor | Sensitivity | true |