chr19:39243455:> Detail (hg38)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr19:39,734,095-39,735,890 |
| hg38 | chr19:39,243,455-39,245,250 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.001 | Cytomegalovirus Infections | Influence of IFNL3/4 polymorphisms on the incidence of cytomegalovirus infection... | BeFree | 25301956 | Detail |
| 0.001 | Cytomegalovirus Infections | In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in... | BeFree | 25777542 | Detail |
| <0.001 | Hepatitis D Infection | NA | BeFree | Detail | |
| 0.120 | Dermatitis, Atopic | NA | CTD_human | Detail | |
| <0.001 | tick-borne encephalitis | Increased concentration of interferon lambda-3, interferon beta and interleukin-... | BeFree | 25461389 | Detail |
| <0.001 | Esophageal Varices | NA | BeFree | Detail | |
| 0.003 | Fatty Liver | Interleukin-28B (IL28B) and patatin-like phospholipase domain containing 3 (PNPL... | BeFree | 25639146 | Detail |
| 0.120 | food allergy | NA | CTD_human | Detail | |
| <0.001 | Foot-and-Mouth Disease | These results suggest that treatment with Ad5-poIFN-λ3 is an effective biotherap... | BeFree | 24786495 | Detail |
| 0.001 | hepatitis | Hepatitis C virus-specific T-cell response correlates with hepatitis activity an... | BeFree | 25338486 | Detail |
| 0.002 | Hepatitis, Chronic | NA | BeFree | Detail | |
| <0.001 | Herpes Simplex Infections | NA | BeFree | Detail | |
| 0.033 | HIV Infections | We examined plasma apolipoprotein concentrations in three cohorts of patients: m... | BeFree,GAD | 24905490 | Detail |
| 0.033 | HIV Infections | To perform a comprehensive study on independent modulators of liver fibrosis pro... | BeFree,GAD | 24905495 | Detail |
| 0.033 | HIV Infections | Short communication: serum-based assay accurately detects single nucleotide poly... | BeFree,GAD | 24946792 | Detail |
| 0.033 | HIV Infections | Furthermore, HCV-RNA testing should be recommended immediately before initiation... | BeFree,GAD | 24951853 | Detail |
| 0.033 | HIV Infections | The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis amo... | BeFree,GAD | 25259701 | Detail |
| 0.033 | HIV Infections | We retrospectively evaluated the impact of IL28B SNPs and other factors on SVR i... | BeFree,GAD | 25742144 | Detail |
| 0.033 | HIV Infections | Favourable IFNL3 genotypes are associated with spontaneous clearance and are dif... | BeFree,GAD | 25803108 | Detail |
| 0.033 | HIV Infections | Decreasing levels of HIV-1 DNA during latency-reversing treatment were also rela... | BeFree,GAD | 26223643 | Detail |
| <0.001 | influenza | IL-28B is a key regulator of B- and T-cell vaccine responses against influenza. | BeFree | 25503988 | Detail |
| 0.220 | hepatitis C | A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated ... | BeFree | 23147144 | Detail |
| 0.005 | Icterus | NA | GAD | Detail | |
| 0.220 | hepatitis C | Conversely, patients with lymphoproliferative disorders had not any significantl... | BeFree | 24707497 | Detail |
| 0.220 | hepatitis C | Single-nucleotide polymorphisms (SNPs) in the IL-10 gene (-1082 [rs1800896], -81... | BeFree | 23880623 | Detail |
| <0.001 | Adult T-Cell Lymphoma/Leukemia | NA | BeFree | Detail | |
| 0.002 | Liver diseases | Several genome-wide association studies have revealed that HLA-DP/DQ, STAT4 and ... | BeFree | 25041342 | Detail |
| 0.002 | Liver diseases | However, very few data are available about its value in predicting sustained vir... | BeFree | 25446338 | Detail |
| 0.002 | Liver diseases | In patients bearing the IFNL3-TT allele, NK cell effector function correlated wi... | BeFree | 26034208 | Detail |
| <0.001 | macular degeneration | NA | BeFree | Detail | |
| <0.001 | meningitis | IL-10, IFNβ and IFNλ3 were up-regulated in csf, with IFNλ3 level higher in patie... | BeFree | 25461389 | Detail |
| <0.001 | meningoencephalitis | IL-10, IFNβ and IFNλ3 were up-regulated in csf, with IFNλ3 level higher in patie... | BeFree | 25461389 | Detail |
| <0.001 | Metabolic Diseases | NA | BeFree | Detail | |
| <0.001 | obesity | NA | BeFree | Detail | |
| <0.001 | Retinal Diseases | NA | BeFree | Detail | |
| <0.001 | RNA Virus Infections | NA | BeFree | Detail | |
| <0.001 | thalassemia | NA | BeFree | Detail | |
| <0.001 | viral hepatitis | NA | BeFree | Detail | |
| <0.001 | Vitamin D Deficiency | NA | BeFree | Detail | |
| <0.001 | Alcohol abuse | NA | BeFree | Detail | |
| <0.001 | Cholestatic hepatitis | NA | BeFree | Detail | |
| <0.001 | Cytomegalovirus retinitis | The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis amo... | BeFree | 25259701 | Detail |
| 0.008 | Fibrosis, Liver | To perform a comprehensive study on independent modulators of liver fibrosis pro... | BeFree | 24905495 | Detail |
| 0.008 | Fibrosis, Liver | To establish the role of liver fibrosis as a predictive tool of response to pegy... | BeFree | 25013899 | Detail |
| 0.008 | Fibrosis, Liver | In contrast, the IL28B genotype does not affect disease progression such as hepa... | BeFree | 25100136 | Detail |
| 0.008 | Fibrosis, Liver | Interestingly, in the subset of patients with baseline advanced liver fibrosis (... | BeFree | 25105286 | Detail |
| 0.008 | Fibrosis, Liver | Liver fibrosis has been associated with hepatitis C virus (HCV) genotype and gen... | BeFree | 25545640 | Detail |
| 0.008 | Fibrosis, Liver | Recently, the role of the IFNL3 polymorphisms in influencing the spontaneous cle... | BeFree | 25864220 | Detail |
| <0.001 | Dyslipidemias | NA | BeFree | Detail | |
| <0.001 | age related macular degeneration | NA | BeFree | Detail | |
| <0.001 | Chronic viral hepatitis | NA | BeFree | Detail | |
| <0.001 | prediabetes syndrome | NA | BeFree | Detail | |
| <0.001 | Non-alcoholic Fatty Liver Disease | NA | BeFree | Detail | |
| <0.001 | Hepatitis D, Chronic | Effects of polymorphisms in interferon λ 3 (interleukin 28B) on sustained virolo... | BeFree | 24582569 | Detail |
| <0.001 | Mixed cryoglobulinemia | Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cry... | BeFree | 26060059 | Detail |
| <0.001 | Carcinogenesis | NA | BeFree | Detail | |
| <0.001 | Biliary stricture | Biliary strictures after liver transplantation: role of interleukin 28B genotype... | BeFree | 25219480 | Detail |
| <0.001 | Primary infection NOS | NA | BeFree | Detail | |
| 0.120 | Squamous cell carcinoma of the head and neck | NA | CTD_human | Detail | |
| <0.001 | Hepatitis, Drug-Induced | NA | BeFree | Detail | |
| <0.001 | Hepatitis C Virus-Related Hepatocellular Carcinoma | NA | BeFree | Detail | |
| <0.001 | Hepatocarcinogenesis | NA | BeFree | Detail | |
| 0.120 | Hepatitis C virus, susceptibility to | NA | ORPHANET | Detail | |
| 0.002 | Steatohepatitis | NA | BeFree | Detail | |
| <0.001 | Allergic disposition | NA | BeFree | Detail | |
| 0.220 | hepatitis C | A nationwide, multi-center prospective study in Japan determined IL28B (rs809991... | BeFree | 24910341 | Detail |
| <0.001 | Infection in children | The purpose of the present review is to summarise the current knowledge on the a... | BeFree | 25071317 | Detail |
| 0.003 | anemia | The primary endpoint was SVR; secondary endpoints examined include (1) patient a... | BeFree | 26034358 | Detail |
| <0.001 | Cooley's anemia | Recently, the role of the IFNL3 polymorphisms in influencing the spontaneous cle... | BeFree | 25864220 | Detail |
| 0.120 | asthma | NA | BeFree,CTD_human | Detail | |
| <0.001 | beta thalassemia | IFNL3 polymorphisms and HCV infection in patients with beta thalassemia. | BeFree | 25864220 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Influence of IFNL3/4 polymorphisms on the incidence of cytomegalovirus infection after solid-organ t... | DisGeNET | Detail |
| In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susc... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Interleukin-28B (IL28B) and patatin-like phospholipase domain containing 3 (PNPLA3) gene polymorphis... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| These results suggest that treatment with Ad5-poIFN-λ3 is an effective biotherapeutic strategy again... | DisGeNET | Detail |
| Hepatitis C virus-specific T-cell response correlates with hepatitis activity and donor IL28B genoty... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We examined plasma apolipoprotein concentrations in three cohorts of patients: mono-infected patient... | DisGeNET | Detail |
| To perform a comprehensive study on independent modulators of liver fibrosis progression and determi... | DisGeNET | Detail |
| Short communication: serum-based assay accurately detects single nucleotide polymorphisms of IL28B a... | DisGeNET | Detail |
| Furthermore, HCV-RNA testing should be recommended immediately before initiation of HCV treatment, t... | DisGeNET | Detail |
| The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected pati... | DisGeNET | Detail |
| We retrospectively evaluated the impact of IL28B SNPs and other factors on SVR in a cohort of 102 HI... | DisGeNET | Detail |
| Favourable IFNL3 genotypes are associated with spontaneous clearance and are differentially distribu... | DisGeNET | Detail |
| Decreasing levels of HIV-1 DNA during latency-reversing treatment were also related to the proportio... | DisGeNET | Detail |
| IL-28B is a key regulator of B- and T-cell vaccine responses against influenza. | DisGeNET | Detail |
| A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinet... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Conversely, patients with lymphoproliferative disorders had not any significantly different IL28B rs... | DisGeNET | Detail |
| Single-nucleotide polymorphisms (SNPs) in the IL-10 gene (-1082 [rs1800896], -819 [rs3021097], and -... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Several genome-wide association studies have revealed that HLA-DP/DQ, STAT4 and IL-28B associated wi... | DisGeNET | Detail |
| However, very few data are available about its value in predicting sustained virologic response (SVR... | DisGeNET | Detail |
| In patients bearing the IFNL3-TT allele, NK cell effector function correlated with liver disease act... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| IL-10, IFNβ and IFNλ3 were up-regulated in csf, with IFNλ3 level higher in patients with the milder ... | DisGeNET | Detail |
| IL-10, IFNβ and IFNλ3 were up-regulated in csf, with IFNλ3 level higher in patients with the milder ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected pati... | DisGeNET | Detail |
| To perform a comprehensive study on independent modulators of liver fibrosis progression and determi... | DisGeNET | Detail |
| To establish the role of liver fibrosis as a predictive tool of response to pegylated interferon alp... | DisGeNET | Detail |
| In contrast, the IL28B genotype does not affect disease progression such as hepatic fibrosis. | DisGeNET | Detail |
| Interestingly, in the subset of patients with baseline advanced liver fibrosis (Metavir F3-F4), thos... | DisGeNET | Detail |
| Liver fibrosis has been associated with hepatitis C virus (HCV) genotype and genetic variation near ... | DisGeNET | Detail |
| Recently, the role of the IFNL3 polymorphisms in influencing the spontaneous clearance of HCV, the r... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Effects of polymorphisms in interferon λ 3 (interleukin 28B) on sustained virologic response to ther... | DisGeNET | Detail |
| Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and re... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine tr... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A nationwide, multi-center prospective study in Japan determined IL28B (rs8099917) genotype, (TA)n o... | DisGeNET | Detail |
| The purpose of the present review is to summarise the current knowledge on the association between s... | DisGeNET | Detail |
| The primary endpoint was SVR; secondary endpoints examined include (1) patient and graft survival; (... | DisGeNET | Detail |
| Recently, the role of the IFNL3 polymorphisms in influencing the spontaneous clearance of HCV, the r... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| IFNL3 polymorphisms and HCV infection in patients with beta thalassemia. | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs129679860 dbSNP
- Genome
- hg38
- Position
- chr19:39,243,455-39,245,250
- Variant Type
- snv
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