U0126
Information
- Drug Name
- U0126
- Description
- Entry(CIViC)
- 2
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| skin melanoma |
BRAF p.Asp634Gly (p.D634G) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asp634Gly (p.D634G) ( ENST00000646891.2, ENST00000496384.7, ENST00000644969.2, ENST00000288602.11 ) |
D |
Predictive
|
Supports
|
Resistance | 3 | 18794803 | Detail | |
| skin melanoma |
BRAF p.Gly509Glu (p.G509E) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly509Glu (p.G509E) ( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) |
D |
Predictive
|
Supports
|
Somatic | 3 | 18794803 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| In this preclinical study, melanoma cell lines har... | BRAF |
BRAF p.Asp634Gly (p.D634G) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asp634Gly (p.D634G) ( ENST00000646891.2, ENST00000496384.7, ENST00000644969.2, ENST00000288602.11 ) |
Resitance or Non-Reponse | true | CIViC Evidence | detail |
| In this preclinical study, melanoma cell lines har... | BRAF |
BRAF p.Gly509Glu (p.G509E) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly509Glu (p.G509E) ( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) |
N/A | true | CIViC Evidence | detail |
| U0126: MEK inhibitor. U0126, a MEK1/2 inhibitor, i... | MAP2K7 | MAP2K7 EXPRESSION | Sensitivity | true | MMMP | detail |
| The addition of Mek-1 inhibitor U0126 decreased an... | MAP2K1 | MAP2K1 EXPRESSION | Sensitivity | true | MMMP | detail |
| U0126 is a MEK inhibitor. Suppression of the MAP k... | AKT1 | AKT1 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| U0126: MEK inhibitor | BRAF | BRAF V600E | Sensitivity | true | MMMP | detail |
| U0126: MEK inhibitor | BRAF | BRAF K601E | Sensitivity | true | MMMP | detail |
| U0126: MEK inhibitor | BRAF | BRAF D595G | Resitance or Non-Reponse | true | MMMP | detail |
| U0126: MEK inhibitor | BRAF | BRAF G469E | Resitance or Non-Reponse | true | MMMP | detail |
| U0126: MEK inhibitor. Apoptosis induction in human... | AIFM1 | AIFM1 UNDEREXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| U0126: MEK inhibitor. Apoptosis induction in human... | MCL1 | MCL1 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| U0126 is a MEK inhibitor. When BRAF is mutated (V6... | BRAF | BRAF V600E | Sensitivity | true | MMMP | detail |