Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
-
BRAF p.Asp634Gly (p.D634G)
(
ENST00000288602.11,
ENST00000496384.7,
ENST00000644969.2,
ENST00000646891.2 )
BRAF p.Asp634Gly (p.D634G) ( ENST00000646891.2, ENST00000496384.7, ENST00000644969.2, ENST00000288602.11 ) - Associated Disease
- skin melanoma
- Source Database
- CIViC Evidence
- Description
- In this preclinical study, melanoma cell lines harboring the kinase-dead G469E- and D594G mutations were identified. These cell lines were resitant to MEK-Inhibition but underwent apoptosis after shRNA-mediated CRAF knowdown or Treatment with the pan-RAF Inhibitor sorafenib.
- Variant Origin
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/6002
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5
- Variant URL
- https://civic.genome.wustl.edu/links/variants/611
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Skin Melanoma
- Evidence Direction
- Supports
- Drug
- U0126
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 18794803
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| U0126 | Resitance or Non-Reponse | true |