Annotation Detail
Information
- Associated Genes
- AIFM1
- Associated Variants
- AIFM1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- U0126: MEK inhibitor. Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
- MMMP State
- downregulated by
- MMMP Molecule
- AIF
- MMMP Molecule Alias
- Apoptosis inducing factor
- MMMP Modifier
- AIF siRNA
- MMMP Relationship
- resistance to
- MMMP Drug
- U0126
- MMMP Drug Alias
- MEK inhibitor
- MMMP Model
- 3
- MMMP Reference
- Wang YF, Clin Cancer Res 2007, 13:4934-42
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| U0126 | Resitance or Non-Reponse | true |