Annotation Detail
Information
- Associated Genes
- AKT1
- Associated Variants
- AKT1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- U0126 is a MEK inhibitor. Suppression of the MAP kinase and PI3K/Akt pathways showed potent anti-melanoma cell effects, including the inhibition of cell proliferation, transformation and invasion, induction of G(0)/G(1) cell cycle arrest and, when the two pathways were dually suppressed, cell apoptosis
- MMMP State
- inhibited by
- MMMP Molecule
- AKT
- MMMP Molecule Alias
- PKB
- MMMP Modifier
- Akti4
- MMMP Relationship
- sensitivity to
- MMMP Drug
- U0126
- MMMP Drug Alias
- MEK inhibitor
- MMMP Model
- 3
- MMMP Reference
- Hou P, PLoS One 2009, 4:e6200
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| U0126 | Sensitivity | true |