Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- U0126 is a MEK inhibitor. When BRAF is mutated (V600E), targeting MEK is more effective than targeting BRAF with sorafenib
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- sensitivity to
- MMMP Drug
- U0126
- MMMP Drug Alias
- MEK inhibitor
- MMMP Model
- 4
- MMMP Reference
- Sharma A, Cancer Res 2006, 66:8200-9
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| U0126 | Sensitivity | true |