Tretinoin

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Information
Drug Name
Tretinoin
Description
Entry(CIViC)
13
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
acute promyelocytic leukemia PML PML-RARA A Predictive Supports Sensitivity/Response Somatic 5 11704842 Detail
acute promyelocytic leukemia PML B2 DOMAIN MUTATION PML B2 DOMAIN MUTATION B Predictive Supports Resistance Somatic 4 23670176 Detail
acute promyelocytic leukemia PML PML-RARA A216V C Predictive Supports Resistance Somatic 4 21613260 Detail
acute promyelocytic leukemia PML PML-RARA L218P C Predictive Supports Resistance Somatic 3 21613260 Detail
acute promyelocytic leukemia FLT3 ITD FLT3 ITD B Predictive Supports Resistance Somatic 4 24981688 Detail
head and neck squamous cell carcinoma ALDH1A2 UNDEREXPRESSION
( ENST00000249750.9 ) ALDH1A2 UNDEREXPRESSION
( ENST00000249750.9 ) 		D Predictive Supports Sensitivity/Response N/A 2 26634247 Detail
acute myeloid leukemia CEBPA MUTATION CEBPA MUTATION B Predictive Does Not Support Sensitivity/Response Somatic 3 19965647 Detail
acute myeloid leukemia FLT3 ITD FLT3 ITD B Predictive Supports Resistance Somatic 3 19965647 Detail
acute myeloid leukemia NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION B Predictive Supports Resistance Somatic 3 19965647 Detail
acute myeloid leukemia NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION B Predictive Supports Sensitivity/Response Somatic 2 19059939 Detail
acute myeloid leukemia NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION D Predictive Supports Sensitivity/Response Somatic 3 21719597 Detail
acute promyelocytic leukemia PML PML-RARA C Predictive Supports Sensitivity/Response Somatic 3 21505136 Detail
acute promyelocytic leukemia PML PML-RARA B Predictive Supports Sensitivity/Response Somatic 5 8674046 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
ATRA/Arsenic combined with standard chemotherapy h... PML PML PML-RARA Sensitivity true CIViC Evidence detail
Mutations in the B2 domain of PML in the PML-RARa ... PML PML B2 DOMAIN MUTATION PML B2 DOMAIN MUTATION Resitance or Non-Reponse true CIViC Evidence detail
The mutation A216V in the B2 domain of PML in the ... PML PML PML-RARA A216V Resitance or Non-Reponse true CIViC Evidence detail
The PML L218P mutation in the PML-RARa fusion was ... PML PML PML-RARA L218P Resitance or Non-Reponse true CIViC Evidence detail
In a study of 171 APL patients treated with combin... FLT3 FLT3 ITD FLT3 ITD Resitance or Non-Reponse true CIViC Evidence detail
FaDu (a high ALDH1A2 expression cell line) and Cal... ALDH1A2 ALDH1A2 UNDEREXPRESSION
( ENST00000249750.9 ) ALDH1A2 UNDEREXPRESSION
( ENST00000249750.9 ) 		Sensitivity true CIViC Evidence detail
In a randomized trial of previously untreated youn... CEBPA CEBPA MUTATION CEBPA MUTATION Sensitivity false CIViC Evidence detail
ATRA treatment did not effect overall survival in ... FLT3 FLT3 ITD FLT3 ITD Resitance or Non-Reponse true CIViC Evidence detail
ATRA treatment did not effect overall survival in ... NPM1 NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION Resitance or Non-Reponse true CIViC Evidence detail
ATRA treatment improved overall and relapse-free s... NPM1 NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION Sensitivity true CIViC Evidence detail
NSC348884 combined with ATRA treatment induces apo... NPM1 NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION Sensitivity true CIViC Evidence detail
A 39-year old woman who presented with acute myelo... PML PML PML-RARA Sensitivity true CIViC Evidence detail
Fusion protein degradation is accelerated upon ATR... PML PML PML-RARA Sensitivity true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT02688140 Active, not recruiting Phase 3 Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia June 2016 January 2025
NCT02339740 Active, not recruiting Phase 3 Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia July 21, 2015 September 22, 2024
NCT06181838 Active, not recruiting N/A Comparison of Quality of Life in Moderate Acne Vulgaris Patients Based on Acne-QoL-INA Using Standard Therapy With and Without Acne Lesions Extraction August 28, 2023 January 3, 2024
NCT00003934 Completed Phase 3 Tretinoin, Cytarabine, and Daunorubicin Hydrochloride With or Without Arsenic Trioxide Followed by Tretinoin With or Without Mercaptopurine and Methotrexate in Treating Patients With Acute Promyelocytic Leukemia June 1999
NCT00005823 Completed Phase 3 Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome December 1998 December 2007
NCT00005863 Completed Phase 3 Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia August 1998 December 2004
NCT02842827 Completed Phase 1/Phase 2 A Study of Bomedemstat (IMG-7289/MK-3543) With and Without ATRA, in Participants With Advanced Myeloid Malignancies (IMG-7289-CTP-101/MK-3543-001) October 6, 2016 October 30, 2018
NCT00003598 Completed N/A UMCC 9609 Tretinoin in Preventing Cancer of the Cervix in Patients With Cervical Neoplasia January 1999 November 2009
NCT00003601 Completed Phase 2 Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus Syndrome February 23, 1999 March 2, 2004
NCT00551460 Completed Phase 2 S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia November 15, 2007 February 5, 2018
NCT00835198 Completed Phase 4 Dapsone Gel 5% and Tretinoin Gel 0.025% Versus Tretinoin Gel 0.025% Monotherapy for Facial Acne Vulgaris December 2008 August 2009
NCT00866918 Completed Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia March 9, 2009 September 30, 2022
NCT01243450 Completed Phase 3 Bioequivalence Study of Generic Tretinoin 0.04% Microsphere Gel, 0.04% Retin-A Micro® and Placebo October 2009 October 2010
NCT01283464 Completed Phase 2 Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles November 2010 December 2011
NCT01406080 Completed Phase 3 A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging January 2013 November 2015
NCT01820624 Completed Phase 1 Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia April 30, 2013 November 13, 2015
NCT02249767 Completed Phase 3 Bioequivalence Study of Tretinoin Gel 0.05% to Brand Tretinoin Gel November 2013 June 2014
NCT02273102 Completed Phase 1 Study of TCP-ATRA for Adult Patients With AML and MDS March 2, 2015 July 1, 2020
NCT02620813 Completed Early Phase 1 De Novo Lipogenesis of Sebaceous Glands in Acne October 2015 October 12, 2017
NCT00002479 Completed Phase 2 Tretinoin in Treating Patients With Mycosis Fungoides or Sezary Syndrome October 1991 August 2002
NCT03999684 Completed Phase 2 A Trial of All-trans Retinoic Acid (ATRA) in Advanced Adenoid Cystic Carcinoma August 5, 2019 April 15, 2020
NCT04080869 Completed Phase 2 Retinyl Palmitate-loaded Ethosomes in Acne Vulgaris January 6, 2020 November 30, 2020
NCT00006239 Completed Phase 1 Phenylbutyrate and Tretinoin in Treating Patients With Hematologic Cancer December 2000 March 2005
NCT00016159 Completed Phase 2 Chemotherapy Plus Monoclonal Antibody in Treating Patients With Acute Promyelocytic Leukemia November 2000
NCT00017225 Completed Phase 2 Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma May 1997 February 2002
NCT00276601 Completed Phase 2 Combination Chemotherapy in Treating Patients With Acute Promyelocytic Leukemia October 2004 June 2013
NCT00382200 Completed Phase 1/Phase 2 Decitabine and Tretinoin in Treating Patients With Myelodysplastic Syndromes July 2006 January 5, 2023
NCT00492856 Completed Phase 3 S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic Leukemia June 1, 2007 May 4, 2016
NCT04919369 Recruiting Phase 1 All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer October 18, 2021 December 31, 2024
NCT01409161 Recruiting Phase 2 Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia October 5, 2011 December 18, 2025
NCT00006220 Terminated Phase 1/Phase 2 Arsenic Trioxide With or Without Tretinoin in Treating Patients With Hematologic Cancer That Has Not Responded to Previous Therapy June 1999 February 2002
NCT00528450 Terminated Phase 2 Tretinoin and Arsenic Trioxide With or Without Idarubicin in Treating Patients With Acute Promyelocytic Leukemia September 2007 January 2011
NCT03878524 Terminated Phase 1 Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial April 1, 2020 December 10, 2020
NCT00002701 Unknown status Phase 3 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic Leukemia October 1995
NCT02704507 Unknown status N/A Addition of a Topical Steroid to a Topical Retinoid in Acne Patients June 2015 June 2016
NCT00514293 Unknown status Phase 2 Bexarotene, Tretinoin, and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer January 2007
NCT00842907 Unknown status Phase 2 Efficacy and Safety of Oral Isotretinoin for Cutaneous Photodamage May 2009 August 2010
NCT00002658 Unknown status Phase 3 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia January 1994
NCT02261779 Unknown status Phase 1/Phase 2 Phase I/II Trial of ATRA and TCP in Patients With Relapsed or Refractory AML and no Intensive Treatment is Possible September 2014 September 2017
NCT00005825 Unknown status Phase 2 Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer September 1998
NCT01349556 Withdrawn N/A Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin Cream May 2011 March 2014