Annotation Detail
Information
- Associated Genes
- CEBPA
- Associated Variants
-
CEBPA MUTATION
CEBPA MUTATION - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- In a randomized trial of previously untreated younger (<60) patients with acute myeloid leukemia (excluding acute promyelocytic leukemia) and high-risk myelodysplastic syndrome CEBPA mutation status had no significant impact on patient response to ATRA (N=20) compared to randomized control (N=15).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/122
- Gene URL
- https://civic.genome.wustl.edu/links/genes/15
- Variant URL
- https://civic.genome.wustl.edu/links/variants/29
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Does Not Support
- Drug
- Tretinoin
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 19965647
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tretinoin | Sensitivity | false |