Annotation Detail
Information
- Associated Genes
- PML
- Associated Variants
- PML PML-RARA
- Associated Disease
- acute promyelocytic leukemia
- Source Database
- CIViC Evidence
- Description
- ATRA/Arsenic combined with standard chemotherapy has been shown to induce a complete remission rate of greater than 75% of patients with acute promyelocytic leukemia harboring the PML-RARa fusion.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1091
- Gene URL
- https://civic.genome.wustl.edu/links/genes/39
- Variant URL
- https://civic.genome.wustl.edu/links/variants/108
- Rating
- 5
- Evidence Type
- Predictive
- Disease
- Acute Promyelocytic Leukemia
- Evidence Direction
- Supports
- Drug
- Arsenic Trioxide,Tretinoin
- Evidence Level
- A
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 11704842
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Arsenic Trioxide | Sensitivity | true |
| Tretinoin | Sensitivity | true |